Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Bushra Ateeq"'
Autor:
Nishat Manzar, Umar Khalid Khan, Ayush Goel, Shannon Carskadon, Nilesh Gupta, Nallasivam Palanisamy, Bushra Ateeq
Publikováno v:
iScience, Vol 27, Iss 3, Pp 108794- (2024)
Summary: Elevated serine peptidase inhibitor, Kazal type 1 (SPINK1) levels in ∼10%–25% of prostate cancer (PCa) patients associate with aggressive phenotype, for which there are limited treatment choices and dismal clinical outcomes. Using an int
Externí odkaz:
https://doaj.org/article/5d40cabf42f84a7eadd63960c7a922f4
Autor:
Sakshi Goel, Vipul Bhatia, Sushmita Kundu, Tanay Biswas, Shannon Carskadon, Nilesh Gupta, Mohammad Asim, Colm Morrissey, Nallasivam Palanisamy, Bushra Ateeq
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Distal-less homeobox 1 (DLX1) is reported as a prostate cancer (PCa) diagnostic biomarker, but the mechanism for its upregulation in PCa is unclear. Here the authors show that ERG, AR and FOXA1 transcriptionally regulates DLX1 expression in PCa, and
Externí odkaz:
https://doaj.org/article/455b94e4205c4b25adcdd9e6f04d6ae9
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 27, Iss , Pp 100777- (2022)
Externí odkaz:
https://doaj.org/article/a3f018eaf870419bbfcfc4d7d24150c8
Autor:
Mohammed Razeeth Shait Mohammed, Mazin Zamzami, Hani Choudhry, Firoz Ahmed, Bushra Ateeq, Mohammad Imran Khan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Epithelial cancer cells that lose attachment from the extracellular matrix (ECM) to seed in a distant organ often undergo anoikis’s specialized form of apoptosis. Recently, KDM3A (H3K9 demethylase) has been identified as a critical effector of anoi
Externí odkaz:
https://doaj.org/article/508c1af2e5a5499ebe8759a9efd05a91
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 10, Pp 497-510 (2020)
Glioblastoma (GBM) represents the most aggressive malignancy of the central nervous system. Increased expression of Angiotensin II Receptor Type 1 (AGTR1) has been associated with proliferative and infiltrative properties of glioma cells. However, th
Externí odkaz:
https://doaj.org/article/2d482c82c45e43bf8815057988e6538b
Autor:
Ritika Tiwari, Nishat Manzar, Vipul Bhatia, Anjali Yadav, Mushtaq A. Nengroo, Dipak Datta, Shannon Carskadon, Nilesh Gupta, Michael Sigouros, Francesca Khani, Matti Poutanen, Amina Zoubeidi, Himisha Beltran, Nallasivam Palanisamy, Bushra Ateeq
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
SPINK1 upregulation is found in ~10–25% of prostate cancers. Here, they show that whilst SPINK1 is transcriptionally repressed by androgen receptor and its co-repressor REST, it is upregulated after androgen-deprivation therapy, which leads to neur
Externí odkaz:
https://doaj.org/article/ed56d705553641adb43a60033adc4409
Autor:
Suza Mohammad Nur, Mohammed Razeeth Shait Mohammed, Mazin A. Zamzami, Hani Choudhry, Aamir Ahmad, Bushra Ateeq, Irfan A. Rather, Mohammad Imran Khan
Publikováno v:
Metabolites, Vol 12, Iss 3, p 267 (2022)
Tumor cells detached from the extracellular matrix (ECM) undergo anoikis resistance and metabolic reprogramming to facilitate cancer cell survival and promote metastasis. During ECM detachment, cancer cells utilize genomic methylation to regulate tra
Externí odkaz:
https://doaj.org/article/5acb3d58193f4bf1948f583967916291
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Despite the current advances in the treatment for prostate cancer, the patients often develop resistance to the conventional therapeutic interventions. Therapy-induced drug resistance and tumor progression have been associated with cellular plasticit
Externí odkaz:
https://doaj.org/article/03d192dbdfae459c9b06b99934aa399d
Autor:
Anjali Bajpai, Taushif Ahmad Quazi, Hong-Wen Tang, Nishat Manzar, Virender Singh, Ashwani Thakur, Bushra Ateeq, Norbert Perrimon, Pradip Sinha
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 7 (2020)
Peptide therapeutics, unlike small-molecule drugs, display crucial advantages of target specificity and the ability to block large interacting interfaces, such as those of transcription factors. The transcription co-factor of the Hippo pathway, YAP/Y
Externí odkaz:
https://doaj.org/article/f203d15dd6da49ed80256ddc04090199
Publikováno v:
Translational Oncology, Vol 11, Iss 2, Pp 233-242 (2018)
Renin angiotensin system (RAS) comprising Angiotensin converting enzyme (ACE), Angiotensin II (Ang II) and its receptor Angiotensin II receptor type I (AGTR1), plays a critical role in several diseases including cancer. A single nucleotide polymorphi
Externí odkaz:
https://doaj.org/article/2ec48997ee044d8ea2b3229ea627e585