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of 15
pro vyhledávání: '"Bushell SR"'
Autor:
Dong, YY, Wang, H, Pike, ACW, Cochrane, SA, Hamedzadeh, S, Wyszyński, FJ, Bushell, SR, Royer, SF, Widdick, DA, Sajid, A, Boshoff, HI, Park, Y, Lucas, R, Liu, W-M, Lee, SS, Machida, T, Minall, L, Mehmood, S, Belaya, K, Liu, W-W, Chu, A, Shrestha, L, Mukhopadhyay, SMM, Strain-Damerell, C, Chalk, R, Burgess-Brown, NA, Bibb, MJ, Barry, CE, Robinson, CV, Beeson, D, Davis, BG, Carpenter, EP
Publikováno v:
Cell
Dong, Y Y, Wang, H, Pike, A C W, Cochrane, S A, Hamedzadeh, S, Wyszynski, F, Bushell, S, Royer, S F, Widdick, D A, Sajid, A, Boshoff, H I, Park, Y, Lucas, R, Liu, W-M, Lee, S S, Machida, T, Minall, L, Mehmood, S, Belaya, K, Liu, W-W, Chu, A, Shrestha, L, Mukhopadhyay, S M M, Strain-Damerell, C, Chalk, R, Burgess-Brown, N A, Bibb, M, Barry 3rd, C, Robinson, C, Beeson, D, Davis, B & Carpenter, E P 2018, ' Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design ', Cell, vol. 175, pp. 1045-1058 . https://doi.org/10.1016/j.cell.2018.10.037
Dong, Y Y, Wang, H, Pike, A C W, Cochrane, S A, Hamedzadeh, S, Wyszynski, F, Bushell, S, Royer, S F, Widdick, D A, Sajid, A, Boshoff, H I, Park, Y, Lucas, R, Liu, W-M, Lee, S S, Machida, T, Minall, L, Mehmood, S, Belaya, K, Liu, W-W, Chu, A, Shrestha, L, Mukhopadhyay, S M M, Strain-Damerell, C, Chalk, R, Burgess-Brown, N A, Bibb, M, Barry 3rd, C, Robinson, C, Beeson, D, Davis, B & Carpenter, E P 2018, ' Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design ', Cell, vol. 175, pp. 1045-1058 . https://doi.org/10.1016/j.cell.2018.10.037
Summary Protein N-glycosylation is a widespread post-translational modification. The first committed step in this process is catalysed by dolichyl-phosphate N-acetylglucosamine-phosphotransferase DPAGT1 (GPT/E.C. 2.7.8.15). Missense DPAGT1 variants c
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https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6d9917953453a97d263ef06d74a47569
https://ora.ox.ac.uk/objects/uuid:515d9416-1e72-4e91-87e4-39eb4f426368
https://ora.ox.ac.uk/objects/uuid:515d9416-1e72-4e91-87e4-39eb4f426368
Akademický článek
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Publikováno v:
ResearcherID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0b3ee7707b1378c8c21c2f9262baf32f
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000234826102062&KeyUID=WOS:000234826102062
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Autor:
Li HZ; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Pike ACW; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Lotsaris I; Molecular Biomedicine Theme, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia., Chi G; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Hansen JS; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Lee SC; School of Biosciences, University of Birmingham, Birmingham, UK., Rödström KEJ; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Bushell SR; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Speedman D; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Evans A; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Wang D; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., He D; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Shrestha L; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Nasrallah C; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Burgess-Brown NA; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Vandenberg RJ; Molecular Biomedicine Theme, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia. robert.vandenberg@sydney.edu.au., Dafforn TR; School of Biosciences, University of Birmingham, Birmingham, UK. t.r.dafforn@bham.ac.uk., Carpenter EP; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK. lizcarpen1@gmail.com., Sauer DB; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK. david.sauer@cmd.ox.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2024 Jun 29; Vol. 15 (1), pp. 5503. Date of Electronic Publication: 2024 Jun 29.
Autor:
Rödström KEJ; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Centre for Medicines Discovery, University of Oxford, Oxford, UK.; Department of Biochemistry, University of Oxford, Oxford, UK., Cloake A; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK., Sörmann J; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Baronina A; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Smith KHM; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Department of Biochemistry, University of Oxford, Oxford, UK., Pike ACW; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Ang J; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Proks P; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Schewe M; Institute of Physiology, Medical Faculty, Kiel University, Kiel, Germany., Holland-Kaye I; Department of Biochemistry, University of Oxford, Oxford, UK., Bushell SR; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Elliott J; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK., Pardon E; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium., Baukrowitz T; Institute of Physiology, Medical Faculty, Kiel University, Kiel, Germany., Owens RJ; The Rosalind Franklin Institute, Harwell Campus, Didcot, UK.; Division of Structural Biology, University of Oxford, Oxford, UK., Newstead S; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Department of Biochemistry, University of Oxford, Oxford, UK.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK., Steyaert J; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium., Carpenter EP; Centre for Medicines Discovery, University of Oxford, Oxford, UK. lizcarpen1@gmail.com.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK. lizcarpen1@gmail.com., Tucker SJ; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2024 May 16; Vol. 15 (1), pp. 4173. Date of Electronic Publication: 2024 May 16.
Autor:
Nie L; Structural Genomics Consortium, Centre for Medicines Discovery, University of Oxford, Oxford, UK.; CRELUX GmbH, Planegg-Martinsried, Germany., Pascoa TC; Structural Genomics Consortium, Centre for Medicines Discovery, University of Oxford, Oxford, UK., Pike ACW; Structural Genomics Consortium, Centre for Medicines Discovery, University of Oxford, Oxford, UK., Bushell SR; Structural Genomics Consortium, Centre for Medicines Discovery, University of Oxford, Oxford, UK.; Orbit Discovery, Oxford, UK., Quigley A; Membrane Protein Laboratory, Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, UK., Ruda GF; Structural Genomics Consortium, Centre for Medicines Discovery, University of Oxford, Oxford, UK.; Evotec Ltd, Milton, Abingdon, UK., Chu A; Structural Genomics Consortium, Centre for Medicines Discovery, University of Oxford, Oxford, UK.; Department of Biochemistry, Oxford University, Oxford, UK., Cole V; Structural Genomics Consortium, Centre for Medicines Discovery, University of Oxford, Oxford, UK.; Genomics Centre, South African Medical Research Council, Cape Town, South Africa., Speedman D; Structural Genomics Consortium, Centre for Medicines Discovery, University of Oxford, Oxford, UK., Moreira T; Structural Genomics Consortium, Centre for Medicines Discovery, University of Oxford, Oxford, UK., Shrestha L; Structural Genomics Consortium, Centre for Medicines Discovery, University of Oxford, Oxford, UK., Mukhopadhyay SMM; Structural Genomics Consortium, Centre for Medicines Discovery, University of Oxford, Oxford, UK., Burgess-Brown NA; Structural Genomics Consortium, Centre for Medicines Discovery, University of Oxford, Oxford, UK., Love JD; Albert Einstein College of Medicine, Department of Biochemistry, Bronx, NY, USA.; Novo Nordisk A/S, Måløv, Denmark., Brennan PE; Structural Genomics Consortium, Centre for Medicines Discovery, University of Oxford, Oxford, UK.; Alzheimer's Research UK Oxford Drug Discovery Institute, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Carpenter EP; Structural Genomics Consortium, Centre for Medicines Discovery, University of Oxford, Oxford, UK. liz.carpenter@cmd.ox.ac.uk.; Vertex Pharmaceuticals Ltd, Milton, Abingdon, UK. liz.carpenter@cmd.ox.ac.uk.
Publikováno v:
Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Jun; Vol. 28 (6), pp. 512-520. Date of Electronic Publication: 2021 Jun 10.
Autor:
Bushell SR; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK., Pike ACW; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK., Falzone ME; Department of Biochemistry, Weill Cornell Medical School, 1300 York Avenue, New York, NY, 10065, USA., Rorsman NJG; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.; OxSyBio, Atlas Building, Harwell Campus, Didcot, Oxfordshire, OX11 0QX, UK., Ta CM; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.; Department of Cardiology, Washington University in St. Louis, St. Louis, MO, 63110, USA., Corey RA; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QT, UK., Newport TD; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QT, UK.; Oxford Nanopore Technologies, Oxford Science Park, Oxford, OX4 4DQ, UK., Christianson JC; Nuffield Department of Rheumatology, Orthopaedics and Musculoskeletal Sciences, University of Oxford, Windmill Road, Oxford, OX3 7LD, UK., Scofano LF; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK., Shintre CA; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.; Vertex Pharmaceuticals Ltd, Milton Park, Oxfordshire, OX14 4RW, UK., Tessitore A; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.; Nuffield Division of Clinical Laboratory Sciences, Oxford University, Oxford, OX3 9DU, UK., Chu A; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.; Department of Biochemistry, Oxford University, Oxford, OX1 3QT, UK., Wang Q; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QT, UK., Shrestha L; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK., Mukhopadhyay SMM; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK., Love JD; Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461-1602, USA.; Novo Nordisk A/S, Novo Nordisk Park, 2760, Måløv, Denmark., Burgess-Brown NA; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK., Sitsapesan R; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK., Stansfeld PJ; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QT, UK., Huiskonen JT; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK., Tammaro P; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK., Accardi A; Department of Biochemistry, Weill Cornell Medical School, 1300 York Avenue, New York, NY, 10065, USA.; Department of Anesthesiology, Weill Cornell Medical School, 25 East 68th Street, New York, NY, 10065, USA.; Department of Physiology and Biophysics, Weill Cornell Medical School, 1300 York Avenue, New York, NY, 10065, USA., Carpenter EP; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK. liz.carpenter@sgc.ox.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2019 Sep 02; Vol. 10 (1), pp. 3956. Date of Electronic Publication: 2019 Sep 02.
Autor:
Dong YY; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Wang H; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Pike ACW; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Cochrane SA; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK; School of Chemistry and Chemical Engineering, Queen's University, Belfast, UK., Hamedzadeh S; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Wyszyński FJ; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Bushell SR; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Royer SF; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Widdick DA; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Sajid A; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA., Boshoff HI; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA., Park Y; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA., Lucas R; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Liu WM; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Lee SS; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Machida T; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Minall L; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Mehmood S; Department of Chemistry, Oxford, OX1 3QZ, UK., Belaya K; Neurosciences Group, Nuffield Department of Clinical Neuroscience, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK., Liu WW; Neurosciences Group, Nuffield Department of Clinical Neuroscience, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK., Chu A; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Shrestha L; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Mukhopadhyay SMM; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Strain-Damerell C; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Chalk R; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Burgess-Brown NA; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Bibb MJ; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Barry Iii CE; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA., Robinson CV; Department of Chemistry, Oxford, OX1 3QZ, UK., Beeson D; Neurosciences Group, Nuffield Department of Clinical Neuroscience, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK., Davis BG; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK. Electronic address: Ben.Davis@chem.ox.ac.uk., Carpenter EP; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK. Electronic address: liz.carpenter@sgc.ox.ac.uk.
Publikováno v:
Cell [Cell] 2018 Nov 01; Vol. 175 (4), pp. 1045-1058.e16.
Autor:
Bushell SR; Biomedical Sciences Research Complex, University of St Andrews, St Andrews KY16 9ST, UK., Mainprize IL, Wear MA, Lou H, Whitfield C, Naismith JH
Publikováno v:
Structure (London, England : 1993) [Structure] 2013 May 07; Vol. 21 (5), pp. 844-53. Date of Electronic Publication: 2013 Apr 25.
Autor:
Lou H; Centre for Biomolecular Sciences, University of St Andrews, St Andrews, United Kingdom., Chen M, Black SS, Bushell SR, Ceccarelli M, Mach T, Beis K, Low AS, Bamford VA, Booth IR, Bayley H, Naismith JH
Publikováno v:
PloS one [PLoS One] 2011; Vol. 6 (10), pp. e25825. Date of Electronic Publication: 2011 Oct 28.