Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Busecan, Aksoydan"'
Autor:
Belma Zengin Kurt, Fatih Sonmez, Serdar Durdagi, Busecan Aksoydan, Ramin Ekhteiari Salmas, Andrea Angeli, Mustafa Kucukislamoglu, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 1042-1052 (2017)
New coumaryl-carboxamide derivatives with the thiourea moiety as a linker between the alkyl chains and/or the heterocycle nucleus were synthesized and their inhibitory activity against the human carbonic anhydrase (hCA) isoforms hCA I, II, VII and IX
Externí odkaz:
https://doaj.org/article/858ec58ac2b449b2b2cfabd1df2de037
Publikováno v:
Biophysical Journal. 122:144a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0c14ea4680597f83ce6f87fc2c4c815
https://doi.org/10.1016/j.bpj.2022.11.942
https://doi.org/10.1016/j.bpj.2022.11.942
Autor:
Busecan Aksoydan, Serdar Durdagi
Publikováno v:
Computers in biology and medicine. 141
Calcitonin gene-related peptide receptor (CGRPR) is a heterodimer protein complex consisting of a class-B G protein-coupled receptor (GPCR) named calcitonin receptor-like receptor (CLR) and an accessory protein, receptor activity modifying protein ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79310eea0109b9c63dc88092a8b70994
https://pubmed.ncbi.nlm.nih.gov/34923287
https://pubmed.ncbi.nlm.nih.gov/34923287
Autor:
Timucin Avsar, Berna Dogan, Muge Didem Orhan, Seyma Calis, Serdar Durdagi, Busecan Aksoydan, Necla Birgül Iyison, Aida Shahraki, Kader Sahin
Publikováno v:
Molecular Informatics
In the current study, we used 7922 FDA approved small molecule drugs as well as compounds in clinical investigation from NIH's NPC database in our drug repurposing study. SARS‐CoV‐2 main protease as well as Spike protein/ACE2 targets were used in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf653a61309bf9315cf13bab2a66045
http://europepmc.org/articles/PMC8646260
http://europepmc.org/articles/PMC8646260
Autor:
Busecan Aksoydan, Serdar Durdagi
Publikováno v:
Journal of Molecular Graphics and Modelling. 116:108254
Calcitonin gene-related peptide receptor (CGRPR) is a heterodimer consisting of CLR and RAMP1 proteins. Activation of the CGRPR with the endogenous peptide CGRP is known to play a crucial role in migraine pathophysiology. CGRP occupies two regions in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7695e4463ac956c8eed19eed2ffbb475
https://doi.org/10.1016/j.jmgm.2022.108254
https://doi.org/10.1016/j.jmgm.2022.108254
Autor:
Dimitrios Damalas, George Liapakis, Ioannis Andreadelis, Andreas G. Tzakos, Johanna Becker-Baldus, Antonios Kolocouris, Sofia Kiriakidi, Uroš Javornik, Thomas Mavromoustakos, Evgenios K. Stylos, Eirini Christodoulou, Nikolaos S. Thomaidis, Busecan Aksoydan, Georgios Leonis, Dimitrios Ntountaniotis, Clemens Glaubitz, Janez Plavec, Vlasios Karageorgos, Maria V. Chatziathanasiadou, Tahsin F. Kellici, Serdar Durdagi, Georgia Valsami, Christos M. Chatzigiannis
Publikováno v:
Molecular Pharmaceutics. 16:1255-1271
Renin-angiotensin aldosterone system inhibitors are for a long time extensively used for the treatment of cardiovascular and renal diseases. AT1 receptor blockers (ARBs or sartans) act as antihypertensive drugs by blocking the octapeptide hormone Ang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df16f0bae18c64d98bd66bd6d7f4cc9e
https://doi.org/10.1021/acs.molpharmaceut.8b01212
https://doi.org/10.1021/acs.molpharmaceut.8b01212
Molecular simulations reveal the impact of RAMP1 on ligand binding and dynamics of CGRPR heterodimer
Autor:
Busecan Aksoydan, Serdar Durdagi
The release of the neuropeptide of calcitonin gene-related peptide (CGRP) plays a key role in the mechanisms of migraine pathology and pain perception as it causes vasodilatation, neurogenic inflammation, mast cell degranulation, sensory signal activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8194a4a4e4c3eee27898da734c88562f
https://doi.org/10.1101/2021.05.10.443383
https://doi.org/10.1101/2021.05.10.443383
Autor:
Gunseli Yildirim, Alaleh Shafiei, Oleksandr Yefanov, Hasan DeMirci, Frédéric Poitevin, Timucin Avsar, Chun Hong Yoon, Muge Didem Orhan, Merve Yigin, Lalehan Oktay, Fulya Aksit, Çağdaş Dağ, Serdar Durdagi, Christopher Kupitz, Omur Guven, Valerio Mariani, Ece Erdemoglu, Ebru Destan, Edward H. Snell, Ismail Erol, Mark S. Hunter, Esra Ayan, Berna Dogan, Mengning Liang, Busecan Aksoydan, A. Batyuk, Ozgur Can, Cengizhan Buyukdag, Sabri O. Besler, Seyma Calis, Brandon Hayes, Matthew Seaberg, Serena Ozabrahamyan, Ilayda Tolu, Gihan K. Ketawala, Anton Barty, Raymond G. Sierra, Kader Sahin, Gokhan Tanisali, Oktay Gocenler, Ali D. Yucel, E. Han Dao, Alpsu Olkan, Ayse B. Peksen, Zhen Su, A. Tolstikova, Sabine Botha, Busra Yuksel, Fatma Betul Ertem
Publikováno v:
Structure 29(12), 1382-1396.e6 (2021). doi:10.1016/j.str.2021.07.007
Structure
Structure (London, England : 1993)
Structure
Structure (London, England : 1993)
The COVID-19 pandemic has resulted in 198 million reported infections and more than 4 million deaths as of July 2021 (covid19.who.int). Research to identify effective therapies for COVID-19 includes: (1) designing a vaccine as future protection; (2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392e9ce96ee7ee4a53bb651f21b45fef
https://bib-pubdb1.desy.de/record/462438
https://bib-pubdb1.desy.de/record/462438
Autor:
Christopher Kupitz, Oleksandr Yefanov, Ilayda Tolu, Berna Dogan, Chun Hong Yoon, A. Tolstikova, Sabri O. Besler, Edward H. Snell, Busra Yuksel, Ismail Erol, Mark S. Hunter, Merve Yigin, Lalehan Oktay, Fulya Aksit, Çağdaş Dağ, Ece Erdemoglu, Brandon Hayes, Betul Ertem, Raymond G. Sierra, Omur Guven, Seyma Calis, Alaleh Shafiei, Zhen Su, Serena Ozabrahamyan, Oktay Gocenler, Gihan K. Ketawala, A. Batyuk, Valerio Mariani, Gunseli Yildirim, Kader Sahin, Esra Ayan, Ozgur Can, Cengizhan Buyukdag, Busecan Aksoydan, Mengning Liang, Frédéric Poitevin, Gokhan Tanisali, Alpsu Olkan, E. Han Dao, Ayse B. Peksen, Anton Barty, Sabine Botha, Ali D. Yucel, Matthew Seaberg, Serdar Durdagi, Ebru Destan, Muge Didem Orhan, Hasan DeMirci, Timucin Avsar
The COVID19 pandemic has resulted in 25+ million reported infections and nearly 850.000 deaths. Research to identify effective therapies for COVID19 includes: i) designing a vaccine as future protection; ii) structure-based drug design; and iii) iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6806eaa683664b89448ef04416faa1d9
https://doi.org/10.1101/2020.09.09.287987
https://doi.org/10.1101/2020.09.09.287987
Autor:
Necla Birgül-İyison, Aida Shahraki, Kader Sahin, Berna Dogan, Busecan Aksoydan, Serdar Durdagi
In this virtual drug repurposing study, we used 7922 FDA approved drugs and compounds in clinical investigation from NPC database. Both apo and holo forms of SARS-CoV-2 Main Protease as well as Spike Protein/ACE2 were used for virtual screening. Init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9028f6409127d51e8b5c5414563e8dcf
https://doi.org/10.26434/chemrxiv.12032712
https://doi.org/10.26434/chemrxiv.12032712