Zobrazeno 1 - 10
of 1 402
pro vyhledávání: '"Buschauer A"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Tigecycline is widely used for treating complicated bacterial infections for which there are no effective drugs. It inhibits bacterial protein translation by blocking the ribosomal A-site. However, even though it is also cytotoxic for human
Externí odkaz:
https://doaj.org/article/adc1134f2314428ab0c1e0d0a7f3d6fb
Autor:
Ken Ikeuchi, Nives Ivic, Robert Buschauer, Jingdong Cheng, Thomas Fröhlich, Yoshitaka Matsuo, Otto Berninghausen, Toshifumi Inada, Thomas Becker, Roland Beckmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract In actively translating 80S ribosomes the ribosomal protein eS7 of the 40S subunit is monoubiquitinated by the E3 ligase Not4 and deubiquitinated by Otu2 upon ribosomal subunit recycling. Despite its importance for translation efficiency the
Externí odkaz:
https://doaj.org/article/399c964c1fa34db4b2366a5130139ce8
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Valentin Mitterer, Matthias Thoms, Robert Buschauer, Otto Berninghausen, Ed Hurt, Roland Beckmann
Publikováno v:
eLife, Vol 12 (2023)
Biogenesis intermediates of nucleolar ribosomal 60S precursor particles undergo a number of structural maturation steps before they transit to the nucleoplasm and are finally exported into the cytoplasm. The AAA+-ATPase Rea1 participates in the nucle
Externí odkaz:
https://doaj.org/article/fb52378858d84783bcbab3ce5ca8009f
Autor:
Biselli, Sabrina, Bresinsky, Merlin, Tropmann, Katharina, Forster, Lisa, Honisch, Claudia, Buschauer, Armin, Bernhardt, Günther, Pockes, Steffen
Publikováno v:
In European Journal of Medicinal Chemistry 15 March 2021 214
Autor:
Antoni, Frauke, Bause, Manuel, Scholler, Matthias, Bauer, Stefanie, Stark, Simone A., Jackson, Scott M., Manolaridis, Ioannis, Locher, Kaspar P., König, Burkhard, Buschauer, Armin, Bernhardt, Günther
Publikováno v:
In European Journal of Medicinal Chemistry 1 April 2020 191
Autor:
Dennis Christoph Harrer, Sebastian Buschauer, Ulrich Sterz, Karin Menhart, Christina Wendl, Daniel Heudobler, Matthias Grube, Tobias Pukrop, Wolfgang Herr, Martin Vogelhuber
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundMetastasized soft-tissue sarcomas still pose a significant therapeutic challenge given the limited efficacy of currently available multimodal treatment strategies. Recent progress in molecular characterization of sarcoma subtypes has enable
Externí odkaz:
https://doaj.org/article/c6cd4504010c4099a848bea71202ebde
Publikováno v:
ChemistryOpen, Vol 8, Iss 3, Pp 285-297 (2019)
Abstract New classes of alkylated hetarylpropylguanidines with different functionality and variation in spacer length were synthesized to determine their behavior at the four histamine receptor (H1R, H2R, H3R, H4R) subtypes. Alkylated guanidines with
Externí odkaz:
https://doaj.org/article/b572012a2d9e45b285cef563b4e460bb
Autor:
Jennifer N Wells, Robert Buschauer, Timur Mackens-Kiani, Katharina Best, Hanna Kratzat, Otto Berninghausen, Thomas Becker, Wendy Gilbert, Jingdong Cheng, Roland Beckmann
Publikováno v:
PLoS Biology, Vol 18, Iss 7, p e3000780 (2020)
Cells adjust to nutrient deprivation by reversible translational shutdown. This is accompanied by maintaining inactive ribosomes in a hibernation state, in which they are bound by proteins with inhibitory and protective functions. In eukaryotes, such
Externí odkaz:
https://doaj.org/article/c96bea8dd8cf41d0a139e5faf0eef849
Publikováno v:
ACS Omega, Vol 3, Iss 3, Pp 2865-2882 (2018)
Externí odkaz:
https://doaj.org/article/383a0c58703247f6979a55e7f6c21bea