Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α3.7I form of α-thalassaemia using genome-wide microarray data [version 1; peer review: 1 approved, 1 approved with reservations]

Autor: Ndila, CM, Nyirongo, V, Macharia, AW, Jeffreys, AE, Rowlands, K, Hubbart, C, Busby, GBJ, Band, G, Harding, RM, Rockett, KA, Williams, TN

Background: The -α3.7I-thalassaemia deletion is very common throughout Africa because it protects against malaria. When undertaking studies to investigate human genetic adaptations to malaria or other diseases, it is important to account for any con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::9e048044c2dbc549c88a877f1b18b9bb
http://hdl.handle.net/10044/1/104846

The peopling of Europe: a genetic perspective

Autor: Busby, GBJ

Following their dispersal out of Africa, humans colonised all continents of the world save one, Antarctica. Whilst Europe was initially peopled soon after this exodus, paleoclimatic, archaeological, and historical evidence suggest that successive wav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::6051330b70764cfc2c6e7c422d727368
https://ora.ox.ac.uk/objects/uuid:026d8e04-b8a4-4923-b1d5-52918d17ec65

Ancient human genomes suggest three ancestral populations for present-day Europeans

Autor: Joanna L. Mountain, Michael F. Hammer, Ruslan Ruizbakiev, Cesare de Filippo, Kumarasamy Thangaraj, David E. C. Cole, Haim Ben-Ami, Leila Laredj, Mark Lipson, Jüri Parik, Valentino Romano, Andres Ruiz-Linares, Fouad Berrada, Dominique Delsate, Ugur Hodoglugil, Antti Sajantila, Olga Utevska, Shahlo Turdikulova, Tor Hervig, Ludmila P. Osipova, Hovhannes Sahakyan, Robert W. Mahley, Ramiro Barrantes, Kirsten I. Bos, Stanislav Dryomov, Peter H. Sudmant, Nadin Rohland, Heng Li, Gabriel Renaud, Mikhail Voevoda, Claudio M. Bravi, Jean-Michel Guinet, Rem I. Sukernik, Joachim Wahl, Matthias Meyer, Christos Economou, Kay Prüfer, Graciela Bailliet, Mait Metspalu, Mikhail Churnosov, Iosif Lazaridis, Johannes Krause, Bonnie Berger, Levon Yepiskoposyan, Francesca Brisighelli, Francesco Calì, Irene Gallego Romero, Oleg Balanovsky, George Ayodo, Alan Cooper, Alissa Mittnik, Julio Molina, George van Driem, Jean-Michel Dugoujon, Larissa Damba, Fedor Platonov, Nick Patterson, David Reich, Thomas B. Nyambo, David Comas, Olga L. Posukh, Béla Melegh, Draga Toncheva, Alena Kushniarevich, Brenna M. Henn, Montgomery Slatkin, René Vasquez, Elena B. Starikovskaya, Joachim Burger, Ayele Tarekegn, Tatijana Zemunik, Ene Metspalu, Sena Karachanak-Yankova, Lalji Singh, Wolfgang Haak, Susanna Sawyer, Rick A. Kittles, Cheryl A. Winkler, Svante Pääbo, Francisco Rothhammer, Marina Gubina, Pierre Zalloua, Aashish R. Jha, Swapan Mallick, Sergi Castellano, Qiaomei Fu, Desislava Nesheva, Sergey Litvinov, Ingrida Uktveryte, Michael Francken, Cosimo Posth, Theologos Loukidis, Cristian Capelli, Janet Kelso, Sarah A. Tishkoff, Toomas Kivisild, Mark G. Thomas, Elin Fornander, Mercedes Villena, Fredrik Hallgren, Vaidutis Kučinskas, Daniel Corach, George B.J. Busby, Judit Bene, William Klitz, Hamza A. Babiker, Karola Kirsanow, Ruth Bollongino, Rita Khusainova, Evan E. Eichler, Sardana A. Fedorova, Klemetti Näkkäläjärvi, Igor Rudan, Susanne Nordenfelt, Joshua G. Schraiber, Elena Balanovska, Antonio Salas, Richard Villems, Gabriel Bedoya, Elza Khusnutdinova

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Nature
PMC
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes1,2,3,4 with 2,345 contemporary humans to show that most present-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63377f5960815494400ab88ada55992
https://www.nature.com/articles/nature13673

An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples.

Autor: Ahouidi A; Hopital Le Dantec, Universite Cheikh Anta Diop, Dakar, Senegal., Ali M; Wellcome Sanger Institute, Hinxton, UK., Almagro-Garcia J; Wellcome Sanger Institute, Hinxton, UK.; MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK., Amambua-Ngwa A; Wellcome Sanger Institute, Hinxton, UK.; Medical Research Council Unit The Gambia, at the London School of Hygiene and Tropical Medicine, Banjul, The Gambia., Amaratunga C; National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, USA., Amato R; Wellcome Sanger Institute, Hinxton, UK.; MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK., Amenga-Etego L; Navrongo Health Research Centre, Ghana Health Service, Navrongo, Ghana.; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana., Andagalu B; United States Army Medical Research Directorate-Africa, Kenya Medical Research Institute/Walter Reed Project, Kisumu, Kenya., Anderson TJC; Texas Biomedical Research Institute, San Antonio, USA., Andrianaranjaka V; Université d'Antananarivo, Antananarivo, Madagascar., Apinjoh T; University of Buea, Buea, Cameroon., Ariani C; Wellcome Sanger Institute, Hinxton, UK., Ashley EA; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand., Auburn S; Menzies School of Health Research, Darwin, Australia.; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Awandare GA; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.; University of Ghana, Legon, Ghana., Ba H; Institut National de Recherche en Santé Publique, Nouakchott, Mauritania., Baraka V; National Institute for Medical Research (NIMR), Dar es Salaam, Tanzania.; Department of Epidemiology, International Health Unit, University of Antwerp, Antwerp, Belgium., Barry AE; Deakin University, Geelong, Australia.; Burnet Institute, Melbourne, Australia.; Walter and Eliza Hall Institute, Melbourne, Australia., Bejon P; KEMRI Wellcome Trust Research Programme, Kilifi, Kenya., Bertin GI; Institute of Research for Development (IRD), Paris, France., Boni MF; Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Vietnam., Borrmann S; Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany., Bousema T; London School of Hygiene and Tropical Medicine, London, UK.; Radboud University Medical Center, Nijmegen, The Netherlands., Branch O; NYU School of Medicine Langone Medical Center, New York, USA., Bull PC; KEMRI Wellcome Trust Research Programme, Kilifi, Kenya.; Department of Pathology, University of Cambridge, Cambridge, UK., Busby GBJ; MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK., Chookajorn T; Mahidol University, Bangkok, Thailand., Chotivanich K; Mahidol University, Bangkok, Thailand., Claessens A; Medical Research Council Unit The Gambia, at the London School of Hygiene and Tropical Medicine, Banjul, The Gambia.; LPHI, MIVEGEC, INSERM, CNRS, IRD, University of Montpellier, Montpellier, France., Conway D; London School of Hygiene and Tropical Medicine, London, UK., Craig A; Liverpool School of Tropical Medicine, Liverpool, UK.; Malawi-Liverpool-Wellcome Trust Clinical Research, Blantyre, Malawi., D'Alessandro U; Medical Research Council Unit The Gambia, at the London School of Hygiene and Tropical Medicine, Banjul, The Gambia., Dama S; Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali., Day NP; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand., Denis B; Malawi-Liverpool-Wellcome Trust Clinical Research, Blantyre, Malawi., Diakite M; Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali., Djimdé A; Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali., Dolecek C; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Dondorp AM; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand., Drakeley C; London School of Hygiene and Tropical Medicine, London, UK., Drury E; Wellcome Sanger Institute, Hinxton, UK., Duffy P; National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, USA., Echeverry DF; Centro Internacional de Entrenamiento e Investigaciones Médicas - CIDEIM, Cali, Colombia.; Universidad Icesi, Cali, Colombia., Egwang TG; Biotech Laboratories, Kampala, Uganda., Erko B; Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia., Fairhurst RM; National Institutes of Health (NIH), Bethesda, USA., Faiz A; Dev Care Foundation, Dhaka, Bangladesh., Fanello CA; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand., Fukuda MM; Department of Immunology and Medicine, US Army Medical Component, Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand., Gamboa D; Laboratorio ICEMR-Amazonia, Laboratorios de Investigacion y Desarrollo, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru., Ghansah A; Nogouchi Memorial Institute for Medical Research, Legon-Accra, Ghana., Golassa L; Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia., Goncalves S; Wellcome Sanger Institute, Hinxton, UK., Hamilton WL; Wellcome Sanger Institute, Hinxton, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Harrison GLA; Walter and Eliza Hall Institute, Melbourne, Australia., Hart L; MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK., Henrichs C; MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK., Hien TT; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Hill CA; Department of Entomology, Purdue University, West Lafayette, USA., Hodgson A; Ghana Health Service, Ministry of Health, Accra, Ghana., Hubbart C; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Imwong M; Mahidol University, Bangkok, Thailand., Ishengoma DS; National Institute for Medical Research (NIMR), Dar es Salaam, Tanzania.; East African Consortium for Clinical Research (EACCR), Dar es Salaam, Tanzania., Jackson SA; Center for Applied Genetic Technologies, University of Georgia, Athens, GA, USA., Jacob CG; Wellcome Sanger Institute, Hinxton, UK., Jeffery B; MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK., Jeffreys AE; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Johnson KJ; MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK., Jyothi D; Wellcome Sanger Institute, Hinxton, UK., Kamaliddin C; Institute of Research for Development (IRD), Paris, France., Kamau E; Walter Reed Army Institute of Research, U.S. Military HIV Research Program, Silver Spring, MD, USA., Kekre M; Wellcome Sanger Institute, Hinxton, UK., Kluczynski K; MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK., Kochakarn T; Wellcome Sanger Institute, Hinxton, UK.; Mahidol University, Bangkok, Thailand., Konaté A; University Félix Houphouët-Boigny, Abidjan, Cote d'Ivoire., Kwiatkowski DP; Wellcome Sanger Institute, Hinxton, UK.; MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Kyaw MP; The Myanmar Oxford Clinical Research Unit, University of Oxford, Yangon, Myanmar.; University of Public Health, Yangon, Myanmar., Lim P; National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, USA.; Medical Care Development International, Maryland, USA., Lon C; Department of Immunology and Medicine, US Army Medical Component, Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand., Loua KM; Institut National de Santé Publique, Conakry, Guinea., Maïga-Ascofaré O; Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; Research in Tropical Medicine, Kwame Nkrumah University of Sciences and Technology, Kumasi, Ghana., Malangone C; Wellcome Sanger Institute, Hinxton, UK., Manske M; Wellcome Sanger Institute, Hinxton, UK., Marfurt J; Menzies School of Health Research, Darwin, Australia., Marsh K; Nuffield Department of Medicine, University of Oxford, Oxford, UK.; African Academy of Sciences, Nairobi, Kenya., Mayxay M; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Vientiane, Lao People's Democratic Republic.; Institute of Research and Education Development (IRED), University of Health Sciences, Ministry of Health, Vientiane, Lao People's Democratic Republic., Miles A; Wellcome Sanger Institute, Hinxton, UK.; MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK., Miotto O; Wellcome Sanger Institute, Hinxton, UK.; MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand., Mobegi V; School of Medicine, University of Nairobi, Nairobi, Kenya., Mokuolu OA; Department of Paediatrics and Child Health, University of Ilorin, Ilorin, Nigeria., Montgomery J; Institute of Vector-Borne Disease, Monash University, Clayton, Victoria, 3800, Australia., Mueller I; Walter and Eliza Hall Institute, Melbourne, Australia.; Barcelona Centre for International Health Research, Barcelona, Spain., Newton PN; Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration, Vientiane, Lao People's Democratic Republic., Nguyen T; Wellcome Sanger Institute, Hinxton, UK., Nguyen TN; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Vietnam., Noedl H; MARIB - Malaria Research Initiative Bandarban, Bandarban, Bangladesh., Nosten F; Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Shoklo Malaria Research Unit, Bangkok, Thailand., Noviyanti R; Eijkman Institute for Molecular Biology, Jakarta, Indonesia., Nzila A; King Fahid University of Petroleum and Minerals (KFUMP), Dharhran, Saudi Arabia., Ochola-Oyier LI; KEMRI Wellcome Trust Research Programme, Kilifi, Kenya., Ocholla H; KEMRI - Centres for Disease Control and Prevention (CDC) Research Program, Kisumu, Kenya.; Centre for Bioinformatics and Biotechnology, University of Nairobi, Nairobi, Kenya., Oduro A; Navrongo Health Research Centre, Ghana Health Service, Navrongo, Ghana., Omedo I; KEMRI Wellcome Trust Research Programme, Kilifi, Kenya., Onyamboko MA; Kinshasa School of Public Health, University of Kinshasa, Kinshasa, Congo, Democratic Republic., Ouedraogo JB; Institut de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso., Oyebola K; Nigerian Institute of Medical Research, Lagos, Nigeria.; Parasitology and Bioinformatics Unit, Faculty of Science, University of Lagos, Lagos, Nigeria., Pearson RD; Wellcome Sanger Institute, Hinxton, UK.; MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK., Peshu N; KEMRI Wellcome Trust Research Programme, Kilifi, Kenya., Phyo AP; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand.; Shoklo Malaria Research Unit, Bangkok, Thailand., Plowe CV; School of Medicine, University of Maryland, Baltimore, MD, USA., Price RN; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand.; Menzies School of Health Research, Darwin, Australia.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Pukrittayakamee S; Mahidol University, Bangkok, Thailand., Randrianarivelojosia M; Institut Pasteur de Madagascar, Antananarivo, Madagascar.; Universités d'Antananarivo et de Mahajanga, Antananarivo, Madagascar., Rayner JC; Wellcome Sanger Institute, Hinxton, UK., Ringwald P; World Health Organization (WHO), Geneva, Switzerland., Rockett KA; Wellcome Sanger Institute, Hinxton, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Rowlands K; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Ruiz L; Universidad Nacional de la Amazonia Peruana, Iquitos, Peru., Saunders D; Department of Immunology and Medicine, US Army Medical Component, Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand., Shayo A; Nelson Mandela Institute of Science and Technology, Arusha, Tanzania., Siba P; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea., Simpson VJ; MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK., Stalker J; Wellcome Sanger Institute, Hinxton, UK., Su XZ; National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, USA., Sutherland C; London School of Hygiene and Tropical Medicine, London, UK., Takala-Harrison S; Center for Vaccine Development and Global Health, University of Maryland, School of Medicine, Baltimore, MD, USA., Tavul L; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea., Thathy V; KEMRI Wellcome Trust Research Programme, Kilifi, Kenya.; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA., Tshefu A; University of Kinshasa, Kinshasa, Congo, Democratic Republic., Verra F; Sapienza University of Rome, Rome, Italy., Vinetz J; Laboratorio ICEMR-Amazonia, Laboratorios de Investigacion y Desarrollo, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru.; Yale School of Medicine, New Haven, CT, USA., Wellems TE; National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, USA., Wendler J; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., White NJ; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand., Wright I; MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK., Yavo W; University Félix Houphouët-Boigny, Abidjan, Cote d'Ivoire.; Malaria Research and Control Center of the National Institute of Public Health, Abidjan, Cote d'Ivoire., Ye H; Department of Medical Research, Yangon, Myanmar.

Publikováno v: Wellcome open research [Wellcome Open Res] 2021 Jul 13; Vol. 6, pp. 42. Date of Electronic Publication: 2021 Jul 13 (Print Publication: 2021).

Resistance to malaria through structural variation of red blood cell invasion receptors.

Autor: Leffler EM; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Band G; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Busby GBJ; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK., Kivinen K; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Le QS; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK., Clarke GM; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK., Bojang KA; Medical Research Council Unit, Atlantic Boulevard, Fajara, Post Office Box 273, The Gambia., Conway DJ; Medical Research Council Unit, Atlantic Boulevard, Fajara, Post Office Box 273, The Gambia.; Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK., Jallow M; Medical Research Council Unit, Atlantic Boulevard, Fajara, Post Office Box 273, The Gambia.; Royal Victoria Teaching Hospital, Independence Drive, Post Office Box 1515, Banjul, The Gambia., Sisay-Joof F; Medical Research Council Unit, Atlantic Boulevard, Fajara, Post Office Box 273, The Gambia., Bougouma EC; Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 2208 Ouagadougou 01, Burkina Faso., Mangano VD; University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy., Modiano D; University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy., Sirima SB; Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 2208 Ouagadougou 01, Burkina Faso., Achidi E; Department of Medical Laboratory Sciences, University of Buea, Post Office Box 63, Buea, South West Region, Cameroon., Apinjoh TO; Department of Biochemistry and Molecular Biology, University of Buea, Post Office Box 63, Buea, South West Region, Cameroon., Marsh K; Kenyan Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Post Office Box 230-80108, Kilifi, Kenya.; Nuffield Department of Medicine, NDM Research Building, Roosevelt Drive, Headington, Oxford OX3 7FZ, UK., Ndila CM; Kenyan Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Post Office Box 230-80108, Kilifi, Kenya., Peshu N; Kenyan Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Post Office Box 230-80108, Kilifi, Kenya., Williams TN; Kenyan Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Post Office Box 230-80108, Kilifi, Kenya.; Faculty of Medicine, Department of Medicine, Imperial College, Exhibition Road, London SW7 2AZ, UK., Drakeley C; Joint Malaria Programme, Kilimanjaro Christian Medical Centre, Post Office Box 2228, Moshi, Tanzania.; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK., Manjurano A; Joint Malaria Programme, Kilimanjaro Christian Medical Centre, Post Office Box 2228, Moshi, Tanzania.; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.; National Institute for Medical Research, Mwanza Research Centre, Mwanza City, Tanzania., Reyburn H; Joint Malaria Programme, Kilimanjaro Christian Medical Centre, Post Office Box 2228, Moshi, Tanzania.; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK., Riley E; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK., Kachala D; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Queen Elizabeth Central Hospital, College of Medicine, Post Office Box 30096, Chichiri, Blantyre 3, Malawi., Molyneux M; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Queen Elizabeth Central Hospital, College of Medicine, Post Office Box 30096, Chichiri, Blantyre 3, Malawi.; Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK., Nyirongo V; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Queen Elizabeth Central Hospital, College of Medicine, Post Office Box 30096, Chichiri, Blantyre 3, Malawi., Taylor T; Blantyre Malaria Project, Queen Elizabeth Central Hospital, College of Medicine, Post Office Box 30096, Chichiri, Blantyre 3, Malawi.; College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA., Thornton N; International Blood Group Reference Laboratory, National Health Service (NHS) Blood and Transplant, 500 North Bristol Park, Filton, Bristol BS34 7QH, UK., Tilley L; International Blood Group Reference Laboratory, National Health Service (NHS) Blood and Transplant, 500 North Bristol Park, Filton, Bristol BS34 7QH, UK., Grimsley S; International Blood Group Reference Laboratory, National Health Service (NHS) Blood and Transplant, 500 North Bristol Park, Filton, Bristol BS34 7QH, UK., Drury E; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Stalker J; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Cornelius V; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK., Hubbart C; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK., Jeffreys AE; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK., Rowlands K; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK., Rockett KA; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Spencer CCA; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. chris.spencer@well.ox.ac.uk dominic.kwiatkowski@sanger.ac.uk., Kwiatkowski DP; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. chris.spencer@well.ox.ac.uk dominic.kwiatkowski@sanger.ac.uk.; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

Publikováno v: Science (New York, N.Y.) [Science] 2017 Jun 16; Vol. 356 (6343). Date of Electronic Publication: 2017 May 18.