Cholinergic signaling mediates the effects of xenin-25 on secretion of pancreatic polypeptide but not insulin or glucagon in humans with impaired glucose tolerance.

Autor: Songyan Wang, Lauren Z Oestricker, Michael J Wallendorf, Karin Sterl, Judit Dunai, C Rachel Kilpatrick, Bruce W Patterson, Dominic N Reeds, Burton M Wice

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0192441 (2018)

We previously demonstrated that infusion of an intestinal peptide called xenin-25 (Xen) amplifies the effects of glucose-dependent insulinotropic polypeptide (GIP) on insulin secretion rates (ISRs) and plasma glucagon levels in humans. However, these

Externí odkaz: https://doaj.org/article/dbb5a054db5b452f96f572e3a993bda6

Enteroendocrine K Cells Exert Complementary Effects to Control Bone Quality and Mass in Mice

Autor: Liv Vv Blom, Béatrice Bouvard, Benoît Gobron, Bolette Hartmann, Peter R. Flatt, Guillaume Mabilleau, Johanne Agerlin Windeløv, Nigel Irwin, Norio Harada, Burton M. Wice, Erick Legrand, Satoko Shimazu-Kuwahara, Daniel Chappard, Geke Aline Boer, Nobuya Inagaki, Sheng Zhang, Jens J. Holst, Mette M. Rosenkilde, Kristian Pedersen, Sagar S. Vyavahare

Publikováno v: Journal of Bone and Mineral Research
Journal of Bone and Mineral Research, American Society for Bone and Mineral Research, 2020, 35 (7), pp.1363-1374. ⟨10.1002/jbmr.4004⟩

The involvement of a gut-bone axis in controlling bone physiology has been long suspected, although the exact mechanisms are unclear. We explored whether glucose-dependent insulinotropic polypeptide (GIP)-producing enteroendocrine K cells were involv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee3ed71caea1e2543473e38a8a3d1ed
https://hal.univ-angers.fr/hal-02946043/file/JBMR_PrePrintVersion.pdf

Stimulation of the endogenous incretin glucose-dependent insulinotropic peptide by enteral dextrose improves glucose homeostasis and inflammation in murine endotoxemia

Autor: Brett J. O’Donnell, Bryce A. Cooper, Lanping Guo, Burton M. Wice, Faraaz Ali Shah, Christopher P. O'Donnell, Yingze Zhang, Sherie McDonald, Bryan J. McVerry, B. Chuan, Darko Stefanovski, Srikanth Singamsetty

Publikováno v: Translational research : the journal of laboratory and clinical medicine. 193

Loss of glucose homeostasis during sepsis is associated with increased organ dysfunction and higher mortality. Novel therapeutic strategies to promote euglycemia in sepsis are needed. We have previously shown that early low-level intravenous (IV) dex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce0357c5db3161f7454a4bea566d1cd
https://pubmed.ncbi.nlm.nih.gov/29222967

Xenin-25 delays gastric emptying and reduces postprandial glucose levels in humans with and without Type 2 diabetes

Autor: Judit Dunai, Hung D. Tran, Sara Chowdhury, Bruce W. Patterson, Songyan Wang, Burton M. Wice, Erin Laciny, Michael Wallendorf, Dan L. Crimmins, David A. Rometo, Kenneth S. Polonsky, Terry A. Griest, Dominic N. Reeds, Jack H. Ladenson

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 306:G301-G309

Xenin-25 (Xen) is a neurotensin-related peptide secreted by a subset of glucose-dependent insulinotropic polypeptide (GIP)-producing enteroendocrine cells. In animals, Xen regulates gastrointestinal function and glucose homeostasis, typically by init

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4334693038f01ee022c6739e64f88e95
https://doi.org/10.1152/ajpgi.00383.2013

Sucralose Affects Glycemic and Hormonal Responses to an Oral Glucose Load

Autor: M. Yanina Pepino, Courtney D. Tiemann, Bruce W. Patterson, Burton M. Wice, Samuel Klein

Publikováno v: Diabetes Care

OBJECTIVE Nonnutritive sweeteners (NNS), such as sucralose, have been reported to have metabolic effects in animal models. However, the relevance of these findings to human subjects is not clear. We evaluated the acute effects of sucralose ingestion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2a12c2d13c96ff9c41a7466344e797
http://europepmc.org/articles/PMC3747933