Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Burton Horowitz"'
Autor:
Burton Horowitz, William J. Hatton, Dayue Duan, Fiona C. Britton, Joseph R. Hume, Charles F. Rossow
Publikováno v:
Acta Physiologica. 187:5-19
Aim: This study investigated the functional role of the CIC-3 amino-terminus in channel regulation in response to changes in cell volume. Methods: Wild-type sClC-3 tagged with a green fluorescence protein (GFP) at the C-terminus was used as a templat
Autor:
Fiona C. Britton, Dayue Duan, Z. Maggie Huang, Joseph R. Hume, Guan-Lei Wang, Burton Horowitz, Linda Ye
Publikováno v:
Journal of Biological Chemistry. 280:25871-25880
A novel volume-regulated hyperpolarization-activated chloride inward rectifier channel (Cl.ir) was identified in mammalian heart. To investigate whether ClC-2 is the gene encoding Cl.ir channels in heart, ClC-2 cDNAs cloned from rat (rClC-2) and guin
Autor:
Burton Horowitz, James Reihill, Brian A. Perrino, Sang Don Koh, Gerard P. Sergeant, Susumu Ohya, Yuji Imaizumi, Kenton M. Sanders, Gregory C. Amberg
Publikováno v:
American Journal of Physiology-Cell Physiology. 288:C304-C313
The voltage-dependent K+channel 4.3 (Kv4.3) is one of the major molecular correlates encoding a class of rapidly inactivating K+currents, including the transient outward current in the heart ( Ito) and A currents ( IA) in neuronal and smooth muscle p
Publikováno v:
Neurogastroenterology and Motility. 16:785-799
Recent reports suggest that cyclo-oxygenase (COX)-2, an inducible COX isoform may be constitutively expressed in gastrointestinal tissues. This study has evaluated the expression and function of COX-2 in the tunica muscularis of the murine proximal c
Autor:
Viktor J. Horváth, Doug Redelman, Lisa J. Miller, Kenton M. Sanders, Burton Horowitz, Tamas Ordog
Publikováno v:
Cytometry Part A. :139-149
Background Interstitial cells of Cajal (ICCs) are mesenchymal cells that play critical roles in gastrointestinal motility as electrical pacemakers and mediators of neuromuscular neurotransmission. Although depletions of ICCs have been implicated in s
Autor:
Ilia A. Yamboliev, Burton Horowitz, Cian M. McCrudden, Joseph R. Hume, Yan-Ping Dai, Ge-Xin Wang
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 287:H533-H544
The serum- and glucocorticoid-inducible kinase (SGK) is a serine/threonine protein kinase (PK) transcriptionally regulated by corticoids, serum, and cell volume. SGK regulates cell volume of various cells by effects on Na(+) and K(+) transport throug
Autor:
Fred S. Lamb, Dayue Duan, Luis L. Liu, Ge-Xin Wang, Kathleen M. Schegg, Shintaro Yamamoto-Mizuma, William J. Hatton, Burton Horowitz, Joseph R. Hume
Publikováno v:
The Journal of Physiology. 557:439-456
ClC-3, a member of the large superfamily of ClC voltage-dependent Cl– channels, has been proposed as a molecular candidate responsible for volume-sensitive osmolyte and anion channels (VSOACs) in some cells, including heart and vascular smooth musc
Autor:
Burton Horowitz, Qi Xi, Dilyara Tcheranova, Helena Parfenova, Charles W. Leffler, Jonathan H. Jaggar
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 286:H610-H618
Carbon monoxide (CO) is a gaseous vasodilator produced by many cell types, including endothelial and smooth muscle cells. The goal of the present study was to investigate signaling mechanisms responsible for CO activation of large-conductance Ca2+-ac
Publikováno v:
Current Opinion in Pharmacology. 3:579-582
Interstitial cells of Cajal (ICC) are a fundamental component of the pacemaker apparatus of the gastrointestinal (GI) tract. ICC generate pacemaker currents that are the basis for slow wave activity in GI muscles. ICC form a network of cells connecte
Autor:
Kevin Monaghan, Kenton M. Sanders, Sang Don Koh, Violeta N. Mutafova-Yambolieva, Burton Horowitz, Salah A. Baker
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 285:G813-G821
Enteric inhibitory responses in gastrointestinal (GI) smooth muscles involve membrane hyperpolarization that transiently reduce the excitability of GI muscles. We examined the possibility that an active repolarization mechanism participates in the re