Early economic evaluation of magnetic resonance imaging for prostate cancer detection in primary care.

Autor: Merriel SWD; University of Manchester Manchester UK.; University of Exeter Exeter UK., Buttle P; Patient & Public Involvement Swindon United Kingdom., Price SJ; University of Exeter Exeter UK., Burns-Cox N; Somerset NHS Foundation Trust Taunton UK., Walter FM; Queen Mary University London London UK., Hamilton W; University of Exeter Exeter UK., Spencer AE; University of Exeter Exeter UK.

Publikováno v: BJUI compass [BJUI Compass] 2024 Jul 10; Vol. 5 (9), pp. 855-864. Date of Electronic Publication: 2024 Jul 10 (Print Publication: 2024).

Re-evaluating the diagnostic efficacy of PSA as a referral test to detect clinically significant prostate cancer in contemporary MRI-based image-guided biopsy pathways.

Autor: Lophatananon A; Division of Population Health, Health Services Research & Primary Care Centre, University of Manchester, UK., Light A; Division of Urology, Department of Surgery, University of Cambridge, UK.; Department of Urology, Cambridge University Hospitals NHS Foundation Trust, UK., Burns-Cox N; Department of Urology, Somerset NHS Foundation Trust, UK., Maccormick A; Department of Urology, Somerset NHS Foundation Trust, UK., John J; Department of Urology, Royal Devon and Exeter NHS Foundation Trust and University of Exeter, UK., Otti V; Department of Urology, Royal Devon and Exeter NHS Foundation Trust and University of Exeter, UK., McGrath J; Department of Urology, Royal Devon and Exeter NHS Foundation Trust and University of Exeter, UK., Archer P; Department of Urology, Southend Hospital, UK., Anning J; Department of Urology, North Bristol NHS Trust, UK., McCracken S; Department of Urology, South Tyneside and Sunderland NHS Trust, UK., Page T; Department of Urology, Newcastle Hospitals NHS Trust, UK., Muir K; Division of Population Health, Health Services Research & Primary Care Centre, University of Manchester, UK., Gnanapragasam VJ; Division of Urology, Department of Surgery, University of Cambridge, UK.; Department of Urology, Cambridge University Hospitals NHS Foundation Trust, UK.; Cambridge Urology Translational Research and Clinical Trials Office, Addenbrooke's Hospital, UK.

Publikováno v: Journal of clinical urology [J Clin Urol] 2023 Jul; Vol. 16 (4), pp. 264-273. Date of Electronic Publication: 2021 Dec 01.

Regional Histopathology and Prostate MRI Positivity: A Secondary Analysis of the PROMIS Trial.

Autor: Stavrinides V; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Norris JM; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Karapanagiotis S; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Giganti F; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Grey A; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Trahearn N; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Freeman A; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Haider A; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Carmona Echeverría LM; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Bott SRJ; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Brown LC; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Burns-Cox N; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Dudderidge TJ; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., El-Shater Bosaily A; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Ghei M; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Henderson A; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Hindley RG; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Kaplan RS; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Oldroyd R; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Parker C; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Persad R; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Rosario DJ; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Shergill IS; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Winkler M; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Kirkham A; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Punwani S; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Whitaker HC; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Ahmed HU; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.)., Emberton M; From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).

Publikováno v: Radiology [Radiology] 2023 Apr; Vol. 307 (1), pp. e220762. Date of Electronic Publication: 2022 Dec 13.

Comparison of TRUS-Biopsy to transperineal template mapping biopsies stratified by multi-parametric MRI score within the PROMIS trial

Autor: Lovegrove, C, Miah, S, El-Shater Bosaily, A, Bott, S, Brown, L, Burns-Cox, N, Dudderidge, T, Freeman, A, Henderson, A, Hindley, R, Kaplan, R, Kirkham, A, Oldroyd, R, Parker, C, Persad, R, Punwani, S, Rosario, D, Shergill, I, Winkler, M, Emberton, M, Ahmed, HU

INTRODUCTION: We evaluated performance of transrectal ultrasound-guided systematic (TRUS) biopsy compared to transperineal template mapping (TPM) with a 5mm sampling frame, stratified by MP-MRI Likert score within the PROMIS study. METHODS: Biopsy-na

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::59bc79e634c63e82ab41c3499139fd83
http://hdl.handle.net/10044/1/72044

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