Výsledky vyhledávání - "Burns C. Blaxall"

Akademický článek

DoubletDecon: Deconvoluting Doublets from Single-Cell RNA-Sequencing Data

Autor: Erica A.K. DePasquale, Daniel J. Schnell, Pieter-Jan Van Camp, Íñigo Valiente-Alandí, Burns C. Blaxall, H. Leighton Grimes, Harinder Singh, Nathan Salomonis

Publikováno v: Cell Reports, Vol 29, Iss 6, Pp 1718-1727.e8 (2019)

Summary: Methods for single-cell RNA sequencing (scRNA-seq) have greatly advanced in recent years. While droplet- and well-based methods have increased the capture frequency of cells for scRNA-seq, these technologies readily produce technical artifac

Externí odkaz: https://doaj.org/article/e450ed2b08594b6593fe46000811201b

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Akademický článek

Cardiac Fibrosis in Proteotoxic Cardiac Disease is Dependent Upon Myofibroblast TGF‐β Signaling

Autor: Bidur Bhandary, Qinghang Meng, Jeanne James, Hanna Osinska, James Gulick, Iñigo Valiente‐Alandi, Michelle A. Sargent, Md. Shenuarin Bhuiyan, Burns C. Blaxall, Jeffery D. Molkentin, Jeffrey Robbins

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 20 (2018)

Background Transforming growth factor beta (TGF‐β) is an important cytokine in mediating the cardiac fibrosis that often accompanies pathogenic cardiac remodeling. Cardiomyocyte‐specific expression of a mutant αB‐crystallin (CryABR120G), whic

Externí odkaz: https://doaj.org/article/761a4cb3cf4649d4b6dd4661f7d03ab3

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Implementing comprehensive pharmacogenomics in a community hospital–associated primary care setting

Autor: Jennifer A. Wick, Tara Schmidlen, Kendra Grande, Chad Moretz, Kristine Ashcraft, Julia Green, Nicolas Moyer, Burns C. Blaxall

Publikováno v: Journal of the American Pharmacists Association. 63:188-192

Pharmacogenomics (PGx) is an emerging field. Many drug-gene interactions are known but not yet routinely addressed in clinical practice. Therefore, there is a significant gap in care, necessitating development of implementation strategies.The objecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbe666f2191de8081ea6c1881650830
https://doi.org/10.1016/j.japh.2022.09.002

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Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility

Publikováno v: Lynch, T L, Kumar, M, McNamara, J W, Kuster, D W D, Sivaguru, M, Singh, R R, Previs, M J, Lee, K H, Kuffel, G, Zilliox, M J, Lin, B L, Ma, W, Gibson, A M, Blaxall, B C, Nieman, M L, Lorenz, J N, Leichter, D M, Leary, O P, Janssen, P M L, de Tombe, P P, Gilbert, R J, Craig, R, Irving, T, Warshaw, D M & Sadayappan, S 2021, ' Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility ', Journal of Molecular and Cellular Cardiology, vol. 156, pp. 33-44 . https://doi.org/10.1016/j.yjmcc.2021.03.009
Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology, Elsevier, 2021, 156, pp.33-44. ⟨10.1016/j.yjmcc.2021.03.009⟩
J Mol Cell Cardiol
Journal of Molecular and Cellular Cardiology, 156, 33-44. Academic Press Inc.

International audience; Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) regulates cardiac contraction through modulation of actomyosin interactions mediated by the protein's amino terminal (N′)-region (C0-C2 domains, 358 amino acids).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9aaf27df6df4e97fdee0c961f48de4d
https://doi.org/10.1016/j.yjmcc.2021.03.009

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Validation of Pharmacogenomic Interaction Probability (PIP) Scores in Predicting Drug–Gene, Drug–Drug–Gene, and Drug–Gene–Gene Interaction Risks in a Large Patient Population

Autor: Kristine Ashcraft, Kendra Grande, Sara L. Bristow, Nicolas Moyer, Tara Schmidlen, Chad Moretz, Jennifer A. Wick, Burns C. Blaxall

Publikováno v: Journal of Personalized Medicine; Volume 12; Issue 12; Pages: 1972

Utilizing pharmacogenomic (PGx) testing and integrating evidence-based guidance in drug therapy enables an improved treatment response and decreases the occurrence of adverse drug events. We conducted a retrospective analysis to validate the YouScrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5cf7c505ac7083a210f6eee764039ab
https://doi.org/10.3390/jpm12121972

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Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure

Autor: George Gardner, Evangelia G. Kranias, Guo-Chang Fan, Guan-Sheng Liu, Jiang Qian, Yutian Li, Nathan Robbins, Kobra Haghighi, Jack Rubinstein, Burns C. Blaxall, Min Jiang, Joshua G. Travers

Publikováno v: JACC: Basic to Translational Science

Visual Abstract
Highlights • PKA-phosphorylation of Hsp20 is elevated in human failing hearts. • Increases in phosphorylated Hsp20 in vivo are associated with fibrotic remodeling and reduced left ventricular function. • The phosphorylated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26181058fcf099bc40c4dd72e341bce2
http://europepmc.org/articles/PMC6488766

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Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

Autor: Onur Kanisicak, Burns C. Blaxall, Justin G. Boyer, Ronald J. Vagnozzi, Jeffery D. Molkentin, Hadi Khalil, Bryan D. Maliken, Xing Fu, Iñigo Valiente-Alandi, Vikram Prasad, Michelle A. Sargent

Publikováno v: The Journal of Clinical Investigation

The identity and function of the fibroblast, a highly prevalent cell type in the heart, have remained poorly defined. Recent faithful genetic lineage–tracing studies revealed that during development, the cardiac fibroblasts are derived from the epi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9263141f21c04673449a9c3a06b46199
http://europepmc.org/articles/PMC5957472

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