Decreased serum zinc is an effect of ageing and not Alzheimer's disease

Autor: Rembach, A, Hare, DJ, Doecke, JD, Burnham, SC, Volitakis, I, Fowler, CJ, Cherny, RA, McLean, C, Grimm, R, Martins, R, Ames, D, Masters, CL, Bush, AI, Roberts, BR

We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::076776b02332b33982a5664cb71d4ff2
https://hdl.handle.net/10453/32810

Considerations for widespread implementation of blood-based biomarkers of Alzheimer's disease.

Autor: Mielke MM; Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Anderson M; Atrium Health, Charlotte, North Carolina, USA., Ashford JW; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.; War Related Illness and Injury Study Center, VA Palo Alto Health Care System, Palo Alto, California, USA., Jeromin A; ALZpath, Carlsbad, California, USA., Lin PJ; Center for the Evaluation of Value and Risk in Health Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA., Rosen A; Palo Alto Veterans Affairs Medical Center, Palo Alto, California, USA.; Stanford University School of Medicine, Stanford, California, USA., Tyrone J; Patient Advocate, California, USA., VandeVrede L; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA., Willis D; Department of Family Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA., Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden., Khachaturian AS; The Campaign to Prevent Alzheimer's Disease, Rockville, Maryland, USA., Schindler SE; Department of Neurology, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA., Weiss J; US Department of Health and Human Services, Health Resources and Services Administration, Bureau of Health Workforce, Rockville, Maryland, USA., Batrla R; Eisai Inc., Nutley, New Jersey, USA., Bozeat S; F. Hoffman-La Roche AG, Basel, Switzerland., Dwyer JR; Global Alzheimer's Platform Foundation, Washington, District of Columbia, USA., Holzapfel D; The Global CEO Initiative on Alzheimer's Disease, Philadelphia, Pennsylvania, USA.; Davos Alzheimer's Collaborative, Philadelphia, Pennsylvania, USA., Jones DR; Eisai Inc., Nutley, New Jersey, USA., Murray JF; Davos Alzheimer's Collaborative, Philadelphia, Pennsylvania, USA., Partrick KA; The Global CEO Initiative on Alzheimer's Disease, Philadelphia, Pennsylvania, USA., Scholler E; The Global CEO Initiative on Alzheimer's Disease, Philadelphia, Pennsylvania, USA.; Davos Alzheimer's Collaborative, Philadelphia, Pennsylvania, USA., Vradenburg G; The Global CEO Initiative on Alzheimer's Disease, Philadelphia, Pennsylvania, USA.; Davos Alzheimer's Collaborative, Philadelphia, Pennsylvania, USA., Young D; Guidehouse, McLean, Virginia, USA., Braunstein JB; C2N Diagnostics, St. Louis, Missouri, USA., Burnham SC; Eli Lilly & Co., Indianapolis, Indiana, USA., de Oliveira FF; Federal University of São Paulo, São Paulo, Brazil., Hu YH; Eisai Inc., Nutley, New Jersey, USA., Mattke S; The USC Brain Health Observatory, University of Southern California, Los Angeles, California, USA., Merali Z; Brain and Mind Institute, Aga Khan University, Nairobi, Kenya., Monane M; C2N Diagnostics, St. Louis, Missouri, USA., Sabbagh MN; Barrow Neurological Institute, Phoenix, Arizona, USA., Shobin E; Biogen, Cambridge, Massachusetts, USA., Weiner MW; Departments of Radiology and Biomedical Imaging, Medicine, Psychiatry, and Neurology, University of California, San Francisco, California, USA., Udeh-Momoh CT; Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.; Brain and Mind Institute, Aga Khan University, Nairobi, Kenya.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Nov; Vol. 20 (11), pp. 8209-8215. Date of Electronic Publication: 2024 Oct 06.

Combining plasma Aβ and p-tau217 improves detection of brain amyloid in non-demented elderly.

Autor: Niimi Y; Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-0033, Japan., Janelidze S; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Sato K; Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-0033, Japan.; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Tomita N; Department of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.; Department of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai, Japan., Tsukamoto T; Department of Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan., Kato T; Department of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Aichi, Japan., Yoshiyama K; Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan., Kowa H; Graduate School of Health Sciences, Kobe University, Hyogo, Japan., Iwata A; Department of Neurology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Ihara R; Department of Neurology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Suzuki K; Division of Neurology, Internal Medicine, National Defense Medical College, Saitama, Japan., Kasuga K; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan., Ikeuchi T; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan., Ishii K; Integrated Research Initiative for Living Well With Dementia, Tokyo Metropolitan Institute for Geriatric and Gerontology, Tokyo, Japan., Ito K; Department of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Aichi, Japan., Nakamura A; Department of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Aichi, Japan., Senda M; Department of Molecular Imaging Research, Kobe City Medical Center General Hospital, Hyogo, Japan., Day TA; Eli Lilly and Company, Indianapolis, USA., Burnham SC; Eli Lilly and Company, Indianapolis, USA., Iaccarino L; Eli Lilly and Company, Indianapolis, USA., Pontecorvo MJ; Eli Lilly and Company, Indianapolis, USA., Hansson O; Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-0033, Japan. oskar.hansson@med.lu.se.; Memory Clinic, Skåne University Hospital, Lund, Sweden. oskar.hansson@med.lu.se., Iwatsubo T; Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-0033, Japan. iwatsubo@m.u-tokyo.ac.jp.; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. iwatsubo@m.u-tokyo.ac.jp.

Publikováno v: Alzheimer's research & therapy [Alzheimers Res Ther] 2024 May 23; Vol. 16 (1), pp. 115. Date of Electronic Publication: 2024 May 23.

Novel Alzheimer's disease genes and epistasis identified using machine learning GWAS platform.

Autor: Lundberg M; Transformational Bioinformatics, Commonwealth Scientific and Industrial Research Organisation, Sydney, NSW, Australia. m.lundberg@uq.net.au.; UQ Frazer Institute, The University of Queensland, Woolloongabba, QLD, Australia. m.lundberg@uq.net.au.; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia. m.lundberg@uq.net.au., Sng LMF; Transformational Bioinformatics, Commonwealth Scientific and Industrial Research Organisation, Sydney, NSW, Australia., Szul P; Health Data Semantics and Interoperability, Commonwealth Scientific and Industrial Research Organisation AU, Brisbane, QLD, Australia., Dunne R; Data61, Commonwealth Scientific and Industrial Research Organisation, Brisbane, QLD, Australia., Bayat A; The Kinghorn Cancer Center (KCCG), Garvan Institute of Medical Research, Sydney, NSW, Australia., Burnham SC; Biomedical Imaging Group, CSIRO, Brisbane, QLD, Australia., Bauer DC; Transformational Bioinformatics, Commonwealth Scientific and Industrial Research Organisation, Sydney, NSW, Australia.; Department of Biomedical Sciences, Faculty of Medicine and Health Science, Macquarie University, Macquarie Park, NSW, Australia.; Applied BioSciences, Faculty of Science and Engineering, Macquarie University, Macquarie Park, NSW, Australia., Twine NA; Transformational Bioinformatics, Commonwealth Scientific and Industrial Research Organisation, Sydney, NSW, Australia. natalie.twine@csiro.au.; Applied BioSciences, Faculty of Science and Engineering, Macquarie University, Macquarie Park, NSW, Australia. natalie.twine@csiro.au.

Publikováno v: Scientific reports [Sci Rep] 2023 Oct 17; Vol. 13 (1), pp. 17662. Date of Electronic Publication: 2023 Oct 17.

Plasma Glial Fibrillary Acidic Protein Is Associated with 18F-SMBT-1 PET: Two Putative Astrocyte Reactivity Biomarkers for Alzheimer's Disease.

Autor: Chatterjee P; Macquarie Medical School, Macquarie University, North Ryde, NSW, Australia.; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia., Doré V; The Australian eHealth Research Centre, CSIRO, Brisbane, QLD, Australia.; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia., Pedrini S; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.; Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, WA, Australia., Krishnadas N; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia.; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia., Thota R; Macquarie Medical School, Macquarie University, North Ryde, NSW, Australia.; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, Australia., Bourgeat P; Health and Biosecurity Flagship, Australian eHealth Research Centre, Herston, QLD, Australia., Ikonomovic MD; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.; Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA., Rainey-Smith SR; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA, Australia.; Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, WA, Australia.; School of Psychological Science, University of Western Australia, Crawley, WA, Australia., Burnham SC; Health and Biosecurity Flagship, Australian eHealth Research Centre, Herston, QLD, Australia., Fowler C; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia., Taddei K; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.; Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, WA, Australia., Mulligan R; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia., Ames D; National Ageing Research Institute, Parkville, VIC, Australia.; Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, VIC, Australia., Masters CL; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia., Fripp J; The Australian eHealth Research Centre, CSIRO, Brisbane, QLD, Australia., Rowe CC; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia.; The Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia., Martins RN; Macquarie Medical School, Macquarie University, North Ryde, NSW, Australia.; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.; Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, WA, Australia.; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, Australia., Villemagne VL; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia.; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2023; Vol. 92 (2), pp. 615-628.