Antimicrobial cetylpyridinium chloride causes functional inhibition of mitochondria as potently as canonical mitotoxicants, nanostructural disruption of mitochondria, and mitochondrial Ca ²⁺ efflux in living rodent and primary human cells.

Autor: Weller SR; Department of Molecular and Biomedical Sciences, 5735 Hitchner, University of Maine, Orono, ME, 04469, USA., Burnell JE; Department of Molecular and Biomedical Sciences, 5735 Hitchner, University of Maine, Orono, ME, 04469, USA., Aho BM; Department of Physics and Astronomy, 5709 Bennett Hall, University of Maine, Orono, ME, 04469, USA., Obeng B; Department of Molecular and Biomedical Sciences, 5735 Hitchner, University of Maine, Orono, ME, 04469, USA., Ledue EL; Department of Molecular and Biomedical Sciences, 5735 Hitchner, University of Maine, Orono, ME, 04469, USA., Shim JK; Department of Biology, Jewett Hall, University of Maine at Augusta, Augusta, ME, 04330, USA., Hess ST; Department of Physics and Astronomy, 5709 Bennett Hall, University of Maine, Orono, ME, 04469, USA. Electronic address: Samuel.hess@maine.edu., Gosse JA; Department of Molecular and Biomedical Sciences, 5735 Hitchner, University of Maine, Orono, ME, 04469, USA. Electronic address: Julie.gosse@maine.edu.

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Apr; Vol. 186, pp. 114547. Date of Electronic Publication: 2024 Feb 24.

Pharmaceutical agent cetylpyridinium chloride inhibits immune mast cell function by interfering with calcium mobilization.

Autor: Obeng B, Potts CM, West BE, Burnell JE, Fleming PJ, Shim JK, Kinney MS, Ledue EL, Sangroula S, Baez Vazquez AY, Gosse JA

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 May 24. Date of Electronic Publication: 2023 May 24.

Triclosan disrupts immune cell function by depressing Ca ²⁺ influx following acidification of the cytoplasm.

Autor: Sangroula S; Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA., Baez Vasquez AY; Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA., Raut P; Department of Physics and Astronomy, University of Maine, Orono, ME, USA., Obeng B; Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA., Shim JK; Department of Biology, University of Maine at Augusta, Augusta, ME, USA., Bagley GD; Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA., West BE; Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA., Burnell JE; Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA., Kinney MS; Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA., Potts CM; Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA., Weller SR; Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA; Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, USA., Kelley JB; Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA; Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, USA., Hess ST; Department of Physics and Astronomy, University of Maine, Orono, ME, USA; Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, USA., Gosse JA; Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA; Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, USA. Electronic address: Julie.gosse@maine.edu.

Publikováno v: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Oct 15; Vol. 405, pp. 115205. Date of Electronic Publication: 2020 Aug 21.