DNA Methylation Signatures of Multiple Sclerosis Occur Independently of Known Genetic Risk and Are Primarily Attributed to B Cells and Monocytes.

Autor: Xavier A; School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, NSW 2305, Australia., Maltby VE; School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, NSW 2305, Australia.; Department of Neurology, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia., Ewing E; Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden., Campagna MP; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia., Burnard SM; School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, NSW 2305, Australia., Tegner JN; Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.; Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.; Unit of Computational Medicine, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, L8:05, 17176 Stockholm, Sweden.; Science for Life Laboratory, Tomtebodavagen 23A, 17165 Solna, Sweden., Slee M; College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia., Butzkueven H; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.; MSBase Foundation, Melbourne, VIC 3004, Australia., Kockum I; Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden., Kular L; Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden., Ausimmune/AusLong Investigators Group, Jokubaitis VG; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia., Kilpatrick T; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC 3052, Australia., Alfredsson L; Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden., Jagodic M; Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden., Ponsonby AL; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC 3052, Australia.; National Centre for Epidemiology and Public Health, Australian National University, Canberra, ACT 2601, Australia., Taylor BV; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia., Scott RJ; School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, NSW 2305, Australia.; Department of Molecular Genetics, Pathology North, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia., Lea RA; School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, NSW 2305, Australia.; Centre for Genomics and Personalised Health, School of Biomedical Science, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia., Lechner-Scott J; School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, NSW 2305, Australia.; Department of Neurology, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Aug 08; Vol. 24 (16). Date of Electronic Publication: 2023 Aug 08.

Capturing SNP Association across the NK Receptor and HLA Gene Regions in Multiple Sclerosis by Targeted Penalised Regression Models.

Autor: Burnard SM; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia.; Centre for Brain and Mental Health (CBMHR), Hunter Medical Research Institute (HMRI), New Lambton Heights, NSW 2305, Australia., Lea RA; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia.; Centre for Brain and Mental Health (CBMHR), Hunter Medical Research Institute (HMRI), New Lambton Heights, NSW 2305, Australia.; Centre of Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia., Benton M; Human Genomics, Kenepuru Science Centre, Institute of Environmental Science and Research, Wellington 5240, New Zealand., Eccles D; Malaghan Institute of Medical Research, Wellington 6242, New Zealand., Kennedy DW; Australian Centre of Excellence for Mathematical and Statistical frontiers, Queensland University of technology, Brisbane, QLD 4000, Australia., Lechner-Scott J; Centre for Brain and Mental Health (CBMHR), Hunter Medical Research Institute (HMRI), New Lambton Heights, NSW 2305, Australia.; School of Medicine and Public Health, University of Newcastle, Callaghan, NSW 2308, Australia.; Department of Neurology, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia., Scott RJ; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia.; Division of Molecular Medicine, NSW Health Pathology-North, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.; Hunter Cancer Research Alliance (HCRA), Hunter Medical Research Institute (HMRI), New Lambton Heights, NSW 2305, Australia.

Publikováno v: Genes [Genes (Basel)] 2021 Dec 29; Vol. 13 (1). Date of Electronic Publication: 2021 Dec 29.