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A multi-specific, multi-affinity antibody platform neutralizes sarbecoviruses and confers protection against SARS-CoV-2 in vivo.

Autor: Burn Aschner C; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada., Muthuraman K; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada., Kucharska I; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada., Cui H; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada., Prieto K; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada., Nair MS; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Wang M; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Huang Y; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Christie-Holmes N; Combined Containment Level 3 Unit, University of Toronto, Toronto, ON M5S 1A8, Canada., Poon B; Combined Containment Level 3 Unit, University of Toronto, Toronto, ON M5S 1A8, Canada., Lam J; Combined Containment Level 3 Unit, University of Toronto, Toronto, ON M5S 1A8, Canada., Sultana A; Combined Containment Level 3 Unit, University of Toronto, Toronto, ON M5S 1A8, Canada., Kozak R; Department of Laboratory Medicine and Molecular Diagnostics, Division of Microbiology, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada.; Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada., Mubareka S; Department of Laboratory Medicine and Molecular Diagnostics, Division of Microbiology, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada.; Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.; Division of Infectious Diseases, Sunnybrook Health Sciences Centre and Department of Medicine, University of Toronto, Toronto, ON M4N 3M5, Canada., Rubinstein JL; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Rujas E; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.; Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain.; Pharmacokinetic, Nanotechnology and Gene Therapy Group, Faculty of Pharmacy, University of the Basque Country UPV/EHU, 01006 Vitoria, Spain.; Bioaraba, Microbiology, Infectious Disease, Antimicrobial Agents, and Gene Therapy, 01006 Vitoria, Spain., Treanor B; Department of Immunology, University of Toronto, ON M5S 1A8, Canada.; Department of Cell and Systems Biology, University of Toronto, ON M5S 3G5, Canada.; Department of Biological Sciences, University of Toronto Scarborough, Toronto, ON M1C 1A4, Canada., Ho DD; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.; Department of Microbiology and Immunology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Jetha A; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada., Julien JP; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Immunology, University of Toronto, ON M5S 1A8, Canada.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 May 24; Vol. 15 (697), pp. eadf4549. Date of Electronic Publication: 2023 May 24.

A Single-Cycle Glycoprotein D Deletion Viral Vaccine Candidate, ΔgD-2, Elicits Polyfunctional Antibodies That Protect against Ocular Herpes Simplex Virus.

Autor: Ramsey NLM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Visciano M; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Hunte R; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Loh LN; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Burn Aschner C; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Jacobs WR Jr; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Herold BC; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA betsy.herold@einsteinmed.org.; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Publikováno v: Journal of virology [J Virol] 2020 Jun 16; Vol. 94 (13). Date of Electronic Publication: 2020 Jun 16 (Print Publication: 2020).

Murine Model of Maternal Immunization Demonstrates Protective Role for Antibodies That Mediate Antibody-Dependent Cellular Cytotoxicity in Protecting Neonates From Herpes Simplex Virus Type 1 and Type 2.

Autor: Kao CM; Departments of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA., Goymer J; Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Loh LN; Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Mahant A; Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Burn Aschner C; Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Herold BC; Departments of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.; Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2020 Feb 18; Vol. 221 (5), pp. 729-738.