Discovery of orally bioavailable 1,3,4-trisubstituted 2-oxopiperazine-based melanocortin-4 receptor agonists as potential antiobesity agents.

Autor: Tian X; Procter & Gamble Pharmaceuticals, Global Business & New Technology Development, Mason, Ohio 45040, USA. xinrong.2.tian@gsk.com, Switzer AG, Derose SA, Mishra RK, Solinsky MG, Mumin RN, Ebetino FH, Jayasinghe LR, Webster ME, Colson AO, Crossdoersen D, Pinney BB, Farmer JA, Dowty ME, Obringer CM, Cruze CA, Burklow ML, Suchanek PM, Dong L, Dirr MK, Sheldon RJ, Wos JA

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2008 Oct 09; Vol. 51 (19), pp. 6055-66. Date of Electronic Publication: 2008 Sep 05.