High fidelity DNA ligation prevents single base insertions in the yeast genome.

Autor: Williams JS; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC, 27709, USA., Lujan SA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC, 27709, USA., Arana ME; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC, 27709, USA., Burkholder AB; Office of Environmental Science Cyberinfrastructure, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC, 27709, USA., Tumbale PP; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC, 27709, USA., Williams RS; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC, 27709, USA., Kunkel TA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC, 27709, USA. kunkel@niehs.nih.gov.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 09; Vol. 15 (1), pp. 8730. Date of Electronic Publication: 2024 Oct 09.

Instability throughout the Saccharomyces cerevisiae genome resulting from Pms1 endonuclease deficiency.

Autor: Lujan SA; Genome Integrity & Structural Biology Laboratory, NIH/NIEHS, DHHS, Research Triangle Park, NC 27709, USA., Garbacz MA; Genome Integrity & Structural Biology Laboratory, NIH/NIEHS, DHHS, Research Triangle Park, NC 27709, USA.; Currently Marta A. Garbacz works at Exact Sciences Corporation, Torrey Pines Science Park, La Jolla, CA 92037, USA., Liberti SE; Aidian Denmark ApS, Copenhagen, Denmark., Burkholder AB; Office of Environmental Science Cyberinfrastructure, NIH/NIEHS, DHHS. Research Triangle Park, NC 27709, USA., Kunkel TA; Genome Integrity & Structural Biology Laboratory, NIH/NIEHS, DHHS, Research Triangle Park, NC 27709, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2024 Sep 09; Vol. 52 (16), pp. 9574-9585.

Comprehensive evaluation of smoking exposures and their interactions on DNA methylation.

Autor: Hoang TT; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA; Department of Pediatrics, Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA; Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA., Lee Y; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway., McCartney DL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK., Kersten ETG; University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Dept. of Pediatric Pulmonology and Pediatric Allergy, Groningen, the Netherlands; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, the Netherlands., Page CM; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway; Department of Physical Health and Ageing, Division for Physical and Mental Health, Norwegian Institute of Public Health, Oslo, Norway., Hulls PM; Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK; MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK., Lee M; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Walker RM; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK; School of Psychology, University of Exeter, Perry Road, Exeter, UK., Breeze CE; UCL Cancer Institute, University College London, Paul O'Gorman Building, London, UK; Altius Institute for Biomedical Sciences, Seattle, WA, USA., Bennett BD; Department of Health and Human Services, Integrative Bioinformatics Support Group, National Institutes of Health, Research Triangle Park, NC, USA., Burkholder AB; Department of Health and Human Services, Office of Environmental Science Cyberinfrastructure, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Ward J; Department of Health and Human Services, Integrative Bioinformatics Support Group, National Institutes of Health, Research Triangle Park, NC, USA., Brantsæter AL; Department of Food Safety, Division of Climate and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway., Caspersen IH; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway., Motsinger-Reif AA; Department of Health and Human Services, Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Richards M; Westat, Durham, NC, USA., White JD; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA; GenOmics and Translational Research Center, Analytics Practice Area, RTI International, Research Triangle Park, NC, USA., Zhao S; Department of Health and Human Services, Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Richmond RC; Population Health Sciences, Bristol Medical School, University of Bristol, BS8 2BN, UK; MRC Integrative Epidemiology Unit at University of Bristol, BS8 2BN, UK., Magnus MC; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway., Koppelman GH; University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Dept. of Pediatric Pulmonology and Pediatric Allergy, Groningen, the Netherlands; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, the Netherlands., Evans KL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK., Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK., Håberg SE; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway., London SJ; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. Electronic address: london2@niehs.nih.gov.

Publikováno v: EBioMedicine [EBioMedicine] 2024 Feb; Vol. 100, pp. 104956. Date of Electronic Publication: 2024 Jan 09.

Vanadium Pentoxide Exposure Causes Strain-Dependent Changes in Mitochondrial DNA Heteroplasmy, Copy Number, and Lesions, but Not Nuclear DNA Lesions.

Autor: Dobson NL; Health and Exercise Department, University of Oklahoma, Norman, OK 73019, USA., Kleeberger SR; National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA., Burkholder AB; National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA., Walters DM; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA., Gladwell W; National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA., Gerrish K; National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA., Vellers HL; Department of Kinesiology and Sport Management, Texas Tech University, Lubbock, TX 79409, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 25; Vol. 24 (19). Date of Electronic Publication: 2023 Sep 25.

Race/ethnicity-stratified fine-mapping of the MHC locus reveals genetic variants associated with late-onset asthma.

Autor: Lee EY; Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, NC, United States., Choi W; Genomics and Bioinformatics Laboratory, Seoul National University, Seoul, Republic of Korea., Burkholder AB; National Institute of Environmental Health Sciences, Durham, NC, United States., Perera L; Genomic Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, Durham, NC, United States., Mack JA; Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, NC, United States.; Department of Obstetrics and Gynecology, University of Cambridge, Cambridge, United Kingdom., Miller FW; Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, Durham, NC, United States., Fessler MB; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Durham, NC, United States., Cook DN; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Durham, NC, United States.; Immunogenetics Group, National Institute of Environmental Health Sciences, Durham, NC, United States., Karmaus PWF; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Durham, NC, United States., Nakano H; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Durham, NC, United States., Garantziotis S; Clinical Research Branch, National Institute of Environmental Health Sciences, Durham, NC, United States., Madenspacher JH; Clinical Research Branch, National Institute of Environmental Health Sciences, Durham, NC, United States., House JS; Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, NC, United States., Akhtari FS; Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, NC, United States.; Clinical Research Branch, National Institute of Environmental Health Sciences, Durham, NC, United States., Schmitt CS; Division of Translational Toxicology, National Institute of Environmental Health Sciences, Durham, NC, United States., Fargo DC; National Institute of Environmental Health Sciences, Durham, NC, United States., Hall JE; Clinical Research Branch, National Institute of Environmental Health Sciences, Durham, NC, United States., Motsinger-Reif AA; Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, NC, United States.

Publikováno v: Frontiers in genetics [Front Genet] 2023 Jun 21; Vol. 14, pp. 1173676. Date of Electronic Publication: 2023 Jun 21 (Print Publication: 2023).