Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Burkhart SC"'
Autor:
Tobias Ronny Haage, Emmanouil Charakopoulos, Vikas Bhuria, Conny K. Baldauf, Mark Korthals, Juliane Handschuh, Peter Müller, Juan Li, Kunjan Harit, Gopala Nishanth, Stephanie Frey, Martin Böttcher, Klaus-Dieter Fischer, Jan Dudeck, Anne Dudeck, Daniel B. Lipka, Burkhart Schraven, Anthony R. Green, Andreas J. Müller, Dimitrios Mougiakakos, Thomas Fischer
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-23 (2024)
Abstract Background Neutrophils play a crucial role in inflammation and in the increased thrombotic risk in myeloproliferative neoplasms (MPNs). We have investigated how neutrophil-specific expression of JAK2-V617F or CALRdel re-programs the function
Externí odkaz:
https://doaj.org/article/de0cb7b1744d4527b1c4f8287f2223f4
Autor:
Vikas Bhuria, Tobias Franz, Conny Baldauf, Martin Böttcher, Nicolas Chatain, Steffen Koschmieder, Tim H. Brümmendorf, Dimitrios Mougiakakos, Burkhart Schraven, Sascha Kahlfuß, Thomas Fischer
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Background Calcium (Ca2+) signaling regulates various vital cellular functions, including integrin activation and cell migration. Store-operated calcium entry (SOCE) via calcium release-activated calcium (CRAC) channels represents a major pa
Externí odkaz:
https://doaj.org/article/db493b9498e045b9a9db0c8fc03508d6
Autor:
Vikas Bhuria, Tobias Franz, Conny Baldauf, Martin Böttcher, Nicolas Chatain, Steffen Koschmieder, Tim H Brümmendorf, Dimitrios Mougiakakos, Burkhart Schraven, Sascha Kahlfuß, Thomas Fischer
Publikováno v:
HemaSphere, Vol 7, p e21609c8 (2023)
Externí odkaz:
https://doaj.org/article/5506c27cb8d042049a0c79cc874e1248
Autor:
Iris Baars, Moritz Jaedtka, Leon-Alexander Dewitz, Yan Fu, Tobias Franz, Juliane Mohr, Patricia Gintschel, Hannes Berlin, Angelina Degen, Sandra Freier, Stefan Rygol, Burkhart Schraven, Sascha Kahlfuß, Ger van Zandbergen, Andreas J. Müller
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
The virulence of intracellular pathogens relies largely on the ability to survive and replicate within phagocytes but also on release and transfer into new host cells. Such cell-to-cell transfer could represent a target for counteracting microbial pa
Externí odkaz:
https://doaj.org/article/50f6bbf74d0449dca586aefd281cb8f2
Autor:
Anna Krone, Yan Fu, Simon Schreiber, Johanna Kotrba, Loisa Borde, Aileen Nötzold, Christoph Thurm, Jonas Negele, Tobias Franz, Sabine Stegemann-Koniszewski, Jens Schreiber, Christoph Garbers, Aniruddh Shukla, Robert Geffers, Burkhart Schraven, Dirk Reinhold, Anne Dudeck, Annegret Reinhold, Andreas J. Müller, Sascha Kahlfuss
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract T helper (Th) cells provide immunity to pathogens but also contribute to detrimental immune responses during allergy and autoimmunity. Th2 cells mediate asthmatic airway inflammation and Th1 cells are involved in the pathogenesis of multiple
Externí odkaz:
https://doaj.org/article/627f9fcd527c42c48b282dfde8d57336
Autor:
Nouria Jantz-Naeem, Romy Böttcher-Loschinski, Katrin Borucki, Marisa Mitchell-Flack, Martin Böttcher, Burkhart Schraven, Dimitrios Mougiakakos, Sascha Kahlfuss
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
One of the key challenges for successful cancer therapy is the capacity of tumors to evade immune surveillance. Tumor immune evasion can be accomplished through the induction of T cell exhaustion via the activation of various immune checkpoint molecu
Externí odkaz:
https://doaj.org/article/9166a3fa89514680929662af73b2b1da
Autor:
Corinna L. Kleinholz, Monika Riek-Burchardt, Elena A. Seiß, Jonas Amore, Patricia Gintschel, Lars Philipsen, Philippe Bousso, Borna Relja, Burkhart Schraven, Juliane Handschuh, Juliane Mohr, Andreas J. Müller
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Neutrophils represent one of the first immune cell types recruited to sites of infection, where they can control pathogens by phagocytosis and cytotoxic mechanisms. Intracellular pathogens such as Leishmania major can hijack neutrophils to e
Externí odkaz:
https://doaj.org/article/f2456a9e704b4f9fa58aa4b2c68737f6
Autor:
Clemens Cammann, Nicole Israel, Sarah Frentzel, Andreas Jeron, Eylin Topfstedt, Thomas Schüler, Luca Simeoni, Martin Zenker, Hans Joerg Fehling, Burkhart Schraven, Dunja Bruder, Ulrike Seifert
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Upon antigen recognition by the T cell receptor (TCR), a complex signaling network orchestrated by protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs) regulates the transmission of the extracellular signal to the nucleus. The rol
Externí odkaz:
https://doaj.org/article/31a0a97d2f9f4dbeb8c340c3bfd11b06
Autor:
Peter Körtvelyessy, Jens Kuhle, Emrah Düzel, Stefan Vielhaber, Christian Schmidt, Annika Heinius, Frank Leypoldt, Burkhart Schraven, Dirk Reinhold, David Leppert, Alexander Goihl
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 11, Pp 2213-2220 (2020)
Abstract Objective Neurofilament light chain (NfL) has been established as a biomarker of axonal damage in many diseases of the central nervous system (CNS). Increased levels of serum NfL (sNfL) can derive as well from damage in the peripheral nervou
Externí odkaz:
https://doaj.org/article/fad66f697bd8493cba4bccf4592ebfdc
Autor:
Peter Müller, Conny K. Baldauf, Tobias R. Haage, Emmanouil Charakopoulos, Martin Böttcher, Vikas Bhuria, Dimitrios Mougiakakos, Burkhart Schraven, Thomas Fischer
Publikováno v:
HemaSphere, Vol 6, Iss 5, p e717 (2022)
Externí odkaz:
https://doaj.org/article/1c549011f0d546eda01c7299a9614f57