The Novel α7 Nicotinic Acetylcholine Receptor AgonistN-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide Improves Working and Recognition Memory in Rodents

Autor: Franz Josef van der Staay, Joachim Luithle, Welf Burkhard Wiese, Marja Van Kampen, Katrin Schnizler, Bernd Riedl, Martin Hendrix, Frank G. Boess, Christoph Methfessel, Timo Flessner, Gerhard Koenig, Christina Erb, Jean De Vry

Publikováno v: The Journal of Pharmacology and Experimental Therapeutics, 321(2), 716-725
The Journal of Pharmacology and Experimental Therapeutics 321 (2007) 2

The relative contribution of alpha 4 beta 2, alpha 7 and other nicotinic acetylcholine receptor ( nAChR) subtypes to the memory enhancing versus the addictive effects of nicotine is the subject of ongoing debate. In the present study, we characterize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27adf8c798c036cb192fb05a756f7dde
https://doi.org/10.1124/jpet.106.118976

Chiral phosphinooxazolines with a bi- or tricyclic oxazoline moiety - applications in Pd-catalyzed allylic alkylations

Autor: Burkhard Wiese, Günter Helmchen

Publikováno v: Tetrahedron Letters. 39:5727-5730

Phosphinooxazolines with a bi- or tricyclic oxazoline moiety are described. In Pd-catalyzed alkylations of 1,3-dimethylallyl acetate with sodium dimethyl malonate enantiomeric excess of up to 89.5 % was obtained. This is the best result so far achiev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c05f09cc3f4219c193e80ef340bab10
https://doi.org/10.1016/s0040-4039(98)01173-3

Preparation of chiral phosphorus, sulfur and selenium containing 2-aryloxazolines

Autor: Thomas Langer, Johannes C. de Jong, Heico Schell, Heiko Rieck, Matthias Kiefer, Günter Helmchen, Peter Sennhenn, Markus Peer, Henning Steinhagen, Jürgen Sprinz, Burkhard Wiese

Publikováno v: Tetrahedron. 52:7547-7583

A series of enantiomerically pure 2-[2-(diarylphosphino)aryl]-oxazolines was prepared from commercially available or synthetic amino alcohols. For oxazoline formation three procedures were employed: ( i ) one pot condensation with a 2-halobenzoic aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93309cbda8fac7006162196ed17c17a1
https://doi.org/10.1016/0040-4020(96)00267-0

ChemInform Abstract: Chiral Phosphinooxazolines with a Bi- or Tricyclic Oxazoline Moiety - Applications in Pd-Catalyzed Allylic Alkylations

Autor: Günter Helmchen, Burkhard Wiese

Publikováno v: ChemInform. 29

Phosphinooxazolines with a bi- or tricyclic oxazoline moiety are described. In Pd-catalyzed alkylations of 1,3-dimethylallyl acetate with sodium dimethyl malonate enantiomeric excess of up to 89.5 % was obtained. This is the best result so far achiev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b82296bd2d7c57a5799e8c54c660c56
https://doi.org/10.1002/chin.199843038

Novel analgesic triglycerides from cultures of Agaricus macrosporus and other basidiomycetes as selective inhibitors of neurolysin

Autor: Marc Stadler, Burkhard Wiese, Dirk Dr Denzer, Nils Burkhardt, Veronika Hellwig, Anke Mayer-Bartschmid

Publikováno v: Stadler, M, Hellwig, V, Mayer-Bartschmid, A, Denzer, D, Wiese, B & Burkhardt, N 2005, ' Novel analgesic triglycerides from cultures of Agaricus macrosporus and other basidiomycetes as selective inhibitors of neurolysin ' Journal of Antibiotics, vol 58, pp. 775-786 .
Stadler, M, Hellwig, V, Mayer-Bartschmid, A, Denzer, D, Wiese, B & Burkhardt, N 2005, ' Novel analgesic triglycerides from cultures of Agaricus macrosporus and other basidiomycetes as selective inhibitors of neurolysin ', Journal of Antibiotics, vol. 58, no. 12, pp. 775-786 . https://doi.org/10.1038/ja.2005.105

The agaricoglycerides are a new class of fungal secondary metabolites that constitute esters of chlorinated 4-hydroxy benzoic acid and glycerol. They are produced in cultures of the edible mushroom, Agaricus macrosporus, and several other basidiomyce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba093f3c36ea1c2b71516dd8e14bc77
https://pubmed.ncbi.nlm.nih.gov/16506695