Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Burkhard Kneitz"'
Autor:
Abdallah Gaballa, Anneli Gebhardt-Wolf, Bastian Krenz, Greta Mattavelli, Mara John, Giacomo Cossa, Silvia Andreani, Christina Schülein-Völk, Francisco Montesinos, Raphael Vidal, Carolin Kastner, Carsten P. Ade, Burkhard Kneitz, Georg Gasteiger, Peter Gallant, Mathias Rosenfeldt, Angela Riedel, Martin Eilers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract In pancreatic ductal adenocarcinoma (PDAC), endogenous MYC is required for S-phase progression and escape from immune surveillance. Here we show that MYC in PDAC cells is needed for the recruitment of the PAF1c transcription elongation compl
Externí odkaz:
https://doaj.org/article/8a9d10af203b42eb8a6cbb3a3a12d74d
Autor:
Mischa J. Kotlyar, Markus Krebs, Antonio Giovanni Solimando, André Marquardt, Maximilian Burger, Hubert Kübler, Ralf Bargou, Susanne Kneitz, Wolfgang Otto, Johannes Breyer, Daniel C. Vergho, Burkhard Kneitz, Charis Kalogirou
Publikováno v:
Cancers, Vol 15, Iss 7, p 1981 (2023)
(1) Background: Clear cell renal cell carcinoma extending into the inferior vena cava (ccRCCIVC) represents a clinical high-risk setting. However, there is substantial heterogeneity within this patient subgroup regarding survival outcomes. Previously
Externí odkaz:
https://doaj.org/article/7d0556c10b864c5fadd5580d8200dae7
Autor:
Mirjam Kiener, Lanpeng Chen, Markus Krebs, Joël Grosjean, Irena Klima, Charis Kalogirou, Hubertus Riedmiller, Burkhard Kneitz, George N. Thalmann, Ewa Snaar-Jagalska, Martin Spahn, Marianna Kruithof-de Julio, Eugenio Zoni
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-17 (2019)
Abstract Background Despite latest advances in prostate cancer (PCa) therapy, PCa remains the third-leading cause of cancer-related death in European men. Dysregulation of microRNAs (miRNAs), small non-coding RNA molecules with gene expression regula
Externí odkaz:
https://doaj.org/article/42994b111bb84267b938f325eaf3f4be
Autor:
Brecht Chys, Gaëtan Devos, Wouter Everaerts, Maarten Albersen, Lisa Moris, Frank Claessens, Gert De Meerleer, Karin Haustermans, Alberto Briganti, Piotr Chlosta, Paolo Gontero, Markus Graefen, Christian Gratzke, R. Jeffrey Karnes, Burkhard Kneitz, Giansilvio Marchioro, Rafael Sanchez Salas, Martin Spahn, Bertrand Tombal, Henk Van Der Poel, Jochen Walz, Hendrik Van Poppel, Steven Joniau
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Background: Cancer-specific survival (CSS) within high-risk non-metastatic prostate cancer varies dramatically. It is likely that within this heterogenous population there are subgroup(s) at extraordinary risk, burdened with an exaptational poor prog
Externí odkaz:
https://doaj.org/article/9841fc2cb1e04052996b03f921b2db0a
Autor:
Markus Krebs, Antonio Giovanni Solimando, Charis Kalogirou, André Marquardt, Torsten Frank, Ioannis Sokolakis, Georgios Hatzichristodoulou, Susanne Kneitz, Ralf Bargou, Hubert Kübler, Bastian Schilling, Martin Spahn, Burkhard Kneitz
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 3, p 670 (2020)
Downregulation of miR-221-3p expression in prostate cancer (PCa) predicted overall and cancer-specific survival of high-risk PCa patients. Apart from PCa, miR-221-3p expression levels predicted a response to tyrosine kinase inhibitors (TKI) in clear
Externí odkaz:
https://doaj.org/article/3187b6b6de6248e5856c6c25d0a57e0f
Autor:
Lisa Moris, Thomas Van den Broeck, Lorenzo Tosco, Anthony Van Baelen, Paolo Gontero, Robert Jeffrey Karnes, Wouter Everaerts, Maarten Albersen, Patrick Jan Bastian, Piotr Chlosta, Frank Claessens, Felix KH Chun, Graefen Markus, Christian Gratzke, Burkhard Kneitz, Giansilvio Marchioro, Rafael Sanchez Salas, Bertrand Tombal, Henk Van Der Poel, Jochen Christoph Walz, Gert De Meerleer, Alberto Bossi, Karin Haustermans, Francesco Montorsi, Hendrik Van Poppel, Martin Spahn, Alberto Briganti, Steven Joniau
Publikováno v:
Frontiers in Surgery, Vol 3 (2016)
Aim: To determine the impact of the extent of lymph node invasion (LNI), on long-term oncological outcomes after radical prostatectomy (RP). Material and methods: In this retrospective study we examined the data of 1249 high-risk, non-metastatic PCa
Externí odkaz:
https://doaj.org/article/e465330528fd4c26a9f80faf98091829
Autor:
Burkhard Kneitz, Hubertus Riedmiller, Claus-Jürgen Scholz, Susanne Kneitz, Maximilian Burger, Evelyne Lerut, Steven Joniau, Martin Spahn, Markus Krebs, Charis Kalogirou
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 11, Pp 21414-21434 (2013)
The treatment of high-risk prostate cancer (HRPCa) is a tremendous challenge for uro-oncologists. The identification of predictive moleculobiological markers allowing risk assessment of lymph node metastasis and systemic progression is essential in e
Externí odkaz:
https://doaj.org/article/e669de3807ee4839b423384247b459e8
Autor:
Kirill Litovkin, Aleyde Van Eynde, Steven Joniau, Evelyne Lerut, Annouschka Laenen, Thomas Gevaert, Olivier Gevaert, Martin Spahn, Burkhard Kneitz, Pierre Gramme, Thibault Helleputte, Sofie Isebaert, Karin Haustermans, Mathieu Bollen
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130651 (2015)
BackgroundProstate cancer (PCa) is a very heterogeneous disease with respect to clinical outcome. This study explored differential DNA methylation in a priori selected genes to diagnose PCa and predict clinical failure (CF) in high-risk patients.Meth
Externí odkaz:
https://doaj.org/article/32869977bdee4077b96941b4ea59216a
Autor:
Peter U Ardelt, Jan Ebbing, Fabian Adams, Cora Reiss, Wadih Arap, Renata Pasqualini, Alexander Bachmann, Ulrich Wetterauer, Hubertus Riedmiller, Burkhard Kneitz
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118646 (2015)
BackgroundTo use combinatorial epitope mapping ("fingerprinting") of the antibody response to identify targets of the humoral immune response in patients with transitional cell carcinoma (TCC) of the bladder.MethodsA combinatorial random peptide libr
Externí odkaz:
https://doaj.org/article/5c6a17c655c14e4aa5244ec25d2536fb
Autor:
Daniel Claudius Vergho, Susanne Kneitz, Charis Kalogirou, Maximilian Burger, Markus Krebs, Andreas Rosenwald, Martin Spahn, Andreas Löser, Arkadius Kocot, Hubertus Riedmiller, Burkhard Kneitz
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109877 (2014)
Clear cell renal cell carcinoma (ccRCC) characterized by a tumor thrombus (TT) extending into the inferior vena cava (IVC) generally indicates poor prognosis. Nevertheless, the risk for tumor recurrence after nephrectomy and thrombectomy varies. An a
Externí odkaz:
https://doaj.org/article/fd5b71c20de04c6fbc105ce348f058eb