Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Burkhard Jakob"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/929740e26cd44ea4bd037eb8addb0f57
Autor:
Isabell Goetting, Safa Larafa, Katharina Eul, Mikhail Kunin, Burkhard Jakob, Johann Matschke, Verena Jendrossek
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Aberrant activation of the phosphatidyl-inositol-3-kinase/protein kinase B (AKT) pathway has clinical relevance to radiation resistance, but the underlying mechanisms are incompletely understood. Protection against reactive oxygen species (ROS) plays
Externí odkaz:
https://doaj.org/article/35b3b28496c444aa9dd9082cb4b9fdc3
Autor:
Nicole B. Averbeck, Carina Barent, Burkhard Jakob, Tatyana Syzonenko, Marco Durante, Gisela Taucher-Scholz
Publikováno v:
Cells, Vol 11, Iss 16, p 2561 (2022)
DNA double-strand breaks (DSBs) represent the molecular origin of ionizing-radiation inflicted biological effects. An increase in the ionization density causes more complex, clustered DSBs that can be processed by resection also in G1 phase, where re
Externí odkaz:
https://doaj.org/article/498e4747b7084cd5ae661080f597fdf6
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5715 (2021)
Exposing cells to DNA damaging agents, such as ionizing radiation (IR) or cytotoxic chemicals, can cause DNA double-strand breaks (DSBs), which are crucial to repair to maintain genetic integrity. O-linked β-N-acetylglucosaminylation (O-GlcNAcylatio
Externí odkaz:
https://doaj.org/article/72cf74d002504a63a19f2f7416335bbc
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6, p 1911 (2020)
Chromatin architecture plays major roles in gene regulation as well as in the repair of DNA damaged by endogenous or exogenous factors, such as after radiation. Opening up the chromatin might provide the necessary accessibility for the recruitment an
Externí odkaz:
https://doaj.org/article/1f866ef7f9e34b9c97679ea0f48fe1f0
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2399 (2018)
In recent years several approaches have been developed to address the chromatin status and its changes in eukaryotic cells under different conditions—but only few are applicable in living cells. Fluorescence lifetime imaging microscopy (FLIM) is a
Externí odkaz:
https://doaj.org/article/18d3bd07c4004ccc8ff95097161aa58b
Autor:
Francesco Tommasino, Thomas Friedrich, Burkhard Jakob, Barbara Meyer, Marco Durante, Michael Scholz
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129416 (2015)
We present here an analysis of DSB induction and processing after irradiation with X-rays in an extended dose range based on the use of the γH2AX assay. The study was performed by quantitative flow cytometry measurements, since the use of foci count
Externí odkaz:
https://doaj.org/article/ac4b7dfaf5ef45728b9fe80d0bbab7ef
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92640 (2014)
Ionizing radiation induces DNA double strand breaks (DSBs) which can lead to the formation of chromosome rearrangements through error prone repair. In mammalian cells the positional stability of chromatin contributes to the maintenance of genome inte
Externí odkaz:
https://doaj.org/article/38ebae6a73d1455aab01c98691d91df2
Autor:
Frank Tobias, Daniel Löb, Nicor Lengert, Marco Durante, Barbara Drossel, Gisela Taucher-Scholz, Burkhard Jakob
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57953 (2013)
The response of cells to ionizing radiation-induced DNA double-strand breaks (DSB) is determined by the activation of multiple pathways aimed at repairing the injury and maintaining genomic integrity. Densely ionizing radiation induces complex damage
Externí odkaz:
https://doaj.org/article/ab7e527472eb43458d9e4ecddf886ab7
Autor:
Fadwa Fatmaoui, Pascal Carrivain, Diana Grewe, Burkhard Jakob, Jean-Marc Victor, Amélie Leforestier, Mikhail Eltsov
The folding of nucleosome chains influences DNA availability for functional interactions necessary to the regulation of transcription, DNA replication and repair. Despite models based on in vitro studies, the nucleosome chain geometry within the crow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d2f2d7cd235e63e92d76a3931f98453
https://doi.org/10.1101/2022.08.16.502515
https://doi.org/10.1101/2022.08.16.502515