Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Burkhard Hinz"'
Autor:
Thomas Freitag, Philipp Kaps, Justus Ramtke, Sarah Bertels, Emily Zunke, Björn Schneider, Anne-Sophie Becker, Dirk Koczan, Daniel Dubinski, Thomas M. Freiman, Felix Wittig, Burkhard Hinz, Mike-Andrew Westhoff, Hannah Strobel, Franziska Meiners, Daniel Wolter, Nadja Engel, Sascha Troschke-Meurer, Wendy Bergmann-Ewert, Susanne Staehlke, Annabell Wolff, Florian Gessler, Christian Junghanss, Claudia Maletzki
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-17 (2024)
Abstract Here, we show that combined use of the EZH2 inhibitor GSK126 and the CDK4/6 inhibitor abemaciclib synergistically enhances antitumoral effects in preclinical GBM models. Dual blockade led to HIF1α upregulation and CalR translocation, accomp
Externí odkaz:
https://doaj.org/article/48c31a82a0d54c5ea79c6f99d70e3d61
Autor:
Franziska Meiners, Burkhard Hinz, Lars Boeckmann, Riccardo Secci, Salem Sueto, Lars Kuepfer, Georg Fuellen, Israel Barrantes
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The major risk factor for chronic disease is chronological age, and age-related chronic diseases account for the majority of deaths worldwide. Targeting senescent cells that accumulate in disease-related tissues presents a strategy to reduce
Externí odkaz:
https://doaj.org/article/62a77b3c732c490bb74fa1ced743bd23
Autor:
Lars Boeckmann, Julia Berner, Marcel Kordt, Elea Lenz, Mirijam Schäfer, Marie–Luise Semmler, Anna Frey, Sanjeev Kumar Sagwal, Henrike Rebl, Lea Miebach, Felix Niessner, Marie Sawade, Martin Hein, Robert Ramer, Eberhard Grambow, Christian Seebauer, Thomas von Woedtke, Barbara Nebe, Hans-Robert Metelmann, Peter Langer, Burkhard Hinz, Brigitte Vollmar, Steffen Emmert, Sander Bekeschus
Publikováno v:
Journal of Advanced Research, Vol 57, Iss , Pp 181-196 (2024)
Introduction: Skin cancer is often fatal, which motivates new therapy avenues. Recent advances in cancer treatment are indicative of the importance of combination treatments in oncology. Previous studies have identified small molecule-based therapies
Externí odkaz:
https://doaj.org/article/d62b86f62ec345ec97ccd3b89d096fd3
Autor:
Anna Richter, Sandra Lange, Clemens Holz, Luisa Brock, Thomas Freitag, Anett Sekora, Gudrun Knuebel, Saskia Krohn, Rico Schwarz, Burkhard Hinz, Hugo Murua Escobar, Christian Junghanss
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Dysregulation of the intrinsic BCL-2 pathway-mediated apoptosis cascade is a common feature of hematological malignancies including acute B-lymphoblastic leukemia (B-ALL). The KMT2A-rearranged high-risk cytogenetic subtype is characterized b
Externí odkaz:
https://doaj.org/article/f965715f9603445aaf305e682578afd1
Autor:
Christin Riess, Katharina del Moral, Adina Fiebig, Philipp Kaps, Charlotte Linke, Burkhard Hinz, Anne Rupprecht, Marcus Frank, Tomas Fiedler, Dirk Koczan, Sascha Troschke-Meurer, Holger N. Lode, Nadja Engel, Thomas Freitag, Carl Friedrich Classen, Claudia Maletzki
Publikováno v:
Cell Death and Disease, Vol 13, Iss 6, Pp 1-14 (2022)
The complex effects of combined CDki/SPyADI application on arginine-auxotrophic glioblastoma multiforme cells. CDki/SPyADI combination therapy impairs cell proliferation, invasiveness, gene expression, induces mitochondrial impairment, and vacuole fo
Externí odkaz:
https://doaj.org/article/e4a237d57e9d4704bd9c0f69a431ba27
Autor:
Franziska Wendt, Felix Wittig, Anne Rupprecht, Robert Ramer, Peter Langer, Steffen Emmert, Marcus Frank, Burkhard Hinz
Publikováno v:
Cells, Vol 12, Iss 19, p 2409 (2023)
Skin cancer is the most common malignant disease worldwide and, therefore, also poses a challenge from a pharmacotherapeutic perspective. Derivatives of indirubin are an interesting option in this context. In the present study, the effects of 3-[3′
Externí odkaz:
https://doaj.org/article/e4d653d7f8ce482784066c1f5d33ff3b
Publikováno v:
Cells, Vol 12, Iss 19, p 2332 (2023)
JZL184, an inhibitor of monoacylglycerol lipase (MAGL) and thus of the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG), mediates various anticancer effects in preclinical studies. However, studies on the effect of this or other MAGL
Externí odkaz:
https://doaj.org/article/b7a6ef19c55d46c69e4510815a9a89f4
Publikováno v:
Cells, Vol 12, Iss 19, p 2389 (2023)
Atherosclerosis is associated with vascular smooth muscle cell proliferation, chronic vascular inflammation, and leukocyte adhesion. In view of the cardioprotective effects of cannabinoids described in recent years, the present study investigated the
Externí odkaz:
https://doaj.org/article/ccf405fb1d664460923f5b4eaba8af69
Publikováno v:
Cells, Vol 12, Iss 13, p 1757 (2023)
Despite the well-described anticarcinogenic effects of endocannabinoids, the influence of the endocannabinoid system on tumor angiogenesis is still debated. In the present study, conditioned medium (CM) from A549 and H358 lung cancer cells treated wi
Externí odkaz:
https://doaj.org/article/8a09d7985957491191bbd21a05b4f6e1
Autor:
Anna Richter, Sina Sender, Annemarie Lenz, Rico Schwarz, Burkhard Hinz, Gudrun Knuebel, Anett Sekora, Hugo Murua Escobar, Christian Junghanss, Catrin Roolf
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Casein kinase II (CK2) is involved in multiple tumor-relevant signaling pathways affecting proliferation and apoptosis. CK2 is frequently upregulated in acute B-lymphoblastic leukemia (B-ALL) and can be targeted by the ATP-competi
Externí odkaz:
https://doaj.org/article/bf338d2f4e8c4aaaafa01b0ae93d5af2