Prediction of ineffectiveness of biological drugs using machine learning and explainable AI methods: data from the Austrian Biological Registry BioReg

Autor: Dubravka Ukalovic, Burkhard F. Leeb, Bernhard Rintelen, Gabriela Eichbauer-Sturm, Peter Spellitz, Rudolf Puchner, Manfred Herold, Miriam Stetter, Vera Ferincz, Johannes Resch-Passini, Jochen Zwerina, Marcus Zimmermann-Rittereiser, Ruth Fritsch-Stork

Publikováno v: Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-12 (2024)

Abstract Objectives Machine learning models can support an individualized approach in the choice of bDMARDs. We developed prediction models for 5 different bDMARDs using machine learning methods based on patient data derived from the Austrian Biologi

Externí odkaz: https://doaj.org/article/913cee245e814dc6866d24e0caf37144

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Autor: Burkhard F, Seiler-Blarer R, Furrer MA

Publikováno v: Aktuelle Urologie [Aktuelle Urol] 2023 Dec; Vol. 54 (6), pp. 487-501. Date of Electronic Publication: 2023 Nov 16.

Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31 846 patients with rheumatoid arthritis in 19 registers from the 'JAK-pot' collaboration

Autor: Kim Lauper, Michele Iudici, Denis Mongin, Sytske Anne Bergstra, Denis Choquette, Catalin Codreanu, René Cordtz, Diederik De Cock, Lene Dreyer, Ori Elkayam, Ellen-Margrethe Hauge, Doreen Huschek, Kimme L Hyrich, Florenzo Iannone, Nevsun Inanc, Lianne Kearsley-Fleet, Eirik Klami Kristianslund, Tore K Kvien, Burkhard F Leeb, Galina Lukina, Dan C Nordström, Karel Pavelka, Manuel Pombo-Suarez, Ziga Rotar, Maria Jose Santos, Anja Strangfeld, Patrick Verschueren, Delphine Sophie Courvoisier, Axel Finckh

Publikováno v: Annals of the Rheumatic Diseases, 81(10). BMJ PUBLISHING GROUP
Lauper, K, Hyrich, K L, Kearsley-Fleet, L & et al. 2022, ' Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31,846 patients with rheumatoid arthritis in 19 registers from the “JAK-pot” collaboration ', Annals of the rheumatic diseases . https://doi.org/10.1136/annrheumdis-2022-222586
Lauper, K, Ludici, M, Mongin, D, Bergstra, S A, Choquette, D, Codreanu, C, Cordtz, R, De Cock, D, Dreyer, L, Elkayam, O, Hauge, E-M, Huschek, D, Hyrich, K L, Iannone, F, Inanc, N, Kearsley-Fleet, L, Kristianslund, E K, Kvien, T K, Leeb, B F, Lukina, G, Nordström, D C, Pavelka, K, Pombo-Suarez, M, Rotar, Z, Santos, M J, Strangfeld, A, Verschueren, P, Courvoisier, D S & Finckh, A 2022, ' Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31 846 patients with rheumatoid arthritis in 19 registers from the 'JAK-pot' collaboration ', Annals of the Rheumatic Diseases, vol. 81, no. 10, 222586, pp. 1358-1366 . https://doi.org/10.1136/annrheumdis-2022-222586
Lauper, K, Iudici, M, Mongin, D, Bergstra, S A, Choquette, D, Codreanu, C, Cordtz, R, De Cock, D, Dreyer, L, Elkayam, O, Hauge, E M, Huschek, D, Hyrich, K L, Iannone, F, Inanc, N, Kearsley-Fleet, L, Kristianslund, E K, Kvien, T K, Leeb, B F, Lukina, G, Nordström, D C, Pavelka, K, Pombo-Suarez, M, Rotar, Z, Santos, M J, Strangfeld, A, Verschueren, P, Courvoisier, D S & Finckh, A 2022, ' Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31 846 patients with rheumatoid arthritis in 19 registers from the 'JAK-pot' collaboration ', Annals of the Rheumatic Diseases, vol. 81, no. 10, pp. 1358-1366 . https://doi.org/10.1136/annrheumdis-2022-222586

BackgroundJAK-inhibitors (JAKi), recently approved in rheumatoid arthritis (RA), have changed the landscape of treatment choices. We aimed to compare the effectiveness of four current second-line therapies of RA with different modes of action, since

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05814942d68a76c3ecb33d7f6c01ede0
http://hdl.handle.net/10138/349608