Enhancing precision in colorectal cancer surgery: development of an LGR5-targeting RSPO1 peptide mimetic as a contrast agent for intraoperative fluorescence molecular imaging.

Autor: Parasido E; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Ribeiro P; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Chingle RM; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Rohwetter T; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Gupta N; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Avetian G; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Bladelli E; Center for Applied Proteomics and Molecular Medicine, George Mason University, Fairfax, VA, USA., Pierobon M; Center for Applied Proteomics and Molecular Medicine, George Mason University, Fairfax, VA, USA., Chen Y; College of Photonic and Electronic Engineering, Fujian Normal University, Fuzhou, Fujian, P. R. China., Tang Q; Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, USA., Schnermann M; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Rodriguez O; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.; Center for Translational Research, Georgetown University Medical Center, Washington, DC, USA., Robbins D; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Burke TR Jr; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Albanese C; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.; Center for Translational Research, Georgetown University Medical Center, Washington, DC, USA.; Department of Radiology, Georgetown University Medical Center, Washington, DC, USA., Ihemelandu C; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.

Publikováno v: Cell cycle (Georgetown, Tex.) [Cell Cycle] 2024 Jul 10, pp. 1-12. Date of Electronic Publication: 2024 Jul 10.

N -Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants.

Autor: Mahajan PS; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States., Smith SJ; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States., Li M; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Craigie R; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Hughes SH; HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States., Zhao XZ; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States., Burke TR Jr; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2024 Mar 08; Vol. 10 (3), pp. 917-927. Date of Electronic Publication: 2024 Feb 12.

Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.

Autor: Li M; National Institute of Diabetes and Digestive Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Oliveira Passos D; The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Shan Z; The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Smith SJ; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA., Sun Q; Center for Biophysics and Computational Biology, and Department of Chemistry, Temple University, Philadelphia, PA 19122, USA., Biswas A; The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Center for Biophysics and Computational Biology and Department of Physics, Temple University, Philadelphia, PA 19122, USA., Choudhuri I; Center for Biophysics and Computational Biology, and Department of Chemistry, Temple University, Philadelphia, PA 19122, USA., Strutzenberg TS; The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Haldane A; Center for Biophysics and Computational Biology and Department of Physics, Temple University, Philadelphia, PA 19122, USA., Deng N; Department of Chemistry and Physical Sciences, Pace University, New York, NY, 10038, USA., Li Z; National Institute of Diabetes and Digestive Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Zhao XZ; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA., Briganti L; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Kvaratskhelia M; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Burke TR Jr; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA., Levy RM; Center for Biophysics and Computational Biology and Department of Physics, Temple University, Philadelphia, PA 19122, USA., Hughes SH; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA., Craigie R; National Institute of Diabetes and Digestive Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Lyumkis D; The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.; Graduate School of Biological Sciences, Section of Molecular Biology, University of California San Diego, La Jolla, CA 92093, USA.

Publikováno v: Science advances [Sci Adv] 2023 Jul 21; Vol. 9 (29), pp. eadg5953. Date of Electronic Publication: 2023 Jul 21.

Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification.

Autor: Zhao XZ; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health Frederick MD USA xuezhi.zhao@nih.gov., Wang W; Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda MD USA., Lountos GT; Basic Science Program, Frederick National Laboratory for Cancer Research Frederick MD USA., Kiselev E; Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda MD USA., Tropea JE; Center for Structural Biology, Center for Cancer Research, National Cancer Institute Frederick MD USA., Needle D; Center for Structural Biology, Center for Cancer Research, National Cancer Institute Frederick MD USA., Pommier Y; Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda MD USA., Burke TR Jr; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health Frederick MD USA xuezhi.zhao@nih.gov.

Publikováno v: RSC chemical biology [RSC Chem Biol] 2023 Mar 27; Vol. 4 (5), pp. 334-343. Date of Electronic Publication: 2023 Mar 27 (Print Publication: 2023).

Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1.

Autor: Zhao XZ; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, United States., Wang W; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States., Lountos GT; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States., Tropea JE; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States., Needle D; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States., Pommier Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States., Burke TR Jr; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, United States.

Publikováno v: Frontiers in chemistry [Front Chem] 2022 Aug 16; Vol. 10, pp. 910953. Date of Electronic Publication: 2022 Aug 16 (Print Publication: 2022).