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Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals

Autor: Guo, Y., Lanktree, M. B., Taylor, K. C., Hakonarson, H., Lange, L. A., Keating, B. J., Fairfax, B. P., Elbers, C. C., Barnard, J., Farrall, M., Padmanabhan, S., Baumert, J., Castillo, B. A., Gaunt, T. R., Gong, Y., Rajagopalan, R., Romaine, S. P., Kumari, M., Rafelt, S., Smith, E. N., Li, Y. R., Sivapalaratnam, S., van Iperen, E. P., Speliotes, E. K., Toskala, E., Zhang, L., Ochs-Balcom, H. M., Bhangale, T. R., Chandrupatla, H. R., Drenos, F., Gieger, C., Gupta, J., Johnson, T., Kleber, M. E., Makino, S., Mangino, M., Meng, Y., Nelson, C. P., Pankow, J. S., Pankratz, N., Price, T. S., Shaffer, J., Shen, H., Tischfield, S., Tomaszewski, M., Atwood, L. D., Bailey, K. M., Balasubramanyam, A., Baldwin, C. T., Basart, H., Bauer, F., Behr, E. R., Beitelshees, A. L., Berenson, G. S., Beresford, S. A., Bezzina, C. R., Bhatt, D. L., Boer, J. M., Braund, P. S., Burke, G. L., Burkley, B., Carty, C., Chen, W., Clarke, R., Cooper-DeHoff, R. M., Curtis, S. P., de Bakker, P. I., de Jong, J. S., Delles, C., Dominiczak, A. F., Duggan, D., Feldman, H. I., Furlong, C. E., Gorski, M. M., Gums, J. G., Hardwick, R., Hastie, C., Heid, I. M., Huang, G.-H., Huggins, G. S., Humphries, S. E., Kirkland, S. A., Kivimaki, M., Klein, R., Klein, B. E., Knowler, W. C., Kottke-Marchant, K., LaCroix, A. Z., Langaee, T. Y., Li, M., Lyon, H. N., Maiwald, S., Marshall, J. K., Mehta, A., Meijs, M. F., Melander, O., Meyer, N., Mitra, N., Molony, C. M., Morrow, D. A., Murugesan, G., Newhouse, S. J., Nieto, J. F., Onland-Moret, N. C., Ouwehand, W. H., Palmen, J., Pepine, C. J., Ranchalis, J., Rosas, S. E., Rosenthal, E. A., Scharnagl, H., Schork, N. J., Schreiner, P. J., Shah, T., Shashaty, M., Shimbo, D., Srinivasan, S. R., Thomas, F., Tobin, M. D., Tsai, M. Y., Verschuren, W. M. M., Wagenknecht, L. E., Winkelmann, B. R., Young, T., Yusuf, S., Zafarmand, M. H., Zmuda, J. M., Zwinderman, A. H., Anand, S. S., Balmforth, A. J., Boehm, B. O., Boerwinkle, E., Burton, P. R., Cappola, T. P., Casas, J. P., Caulfield, M. J., Christiani, D. C., Christie, J., Cruickshanks, K. J., Davey-Smith, G., Davidson, K. W., Day, I. N., Doevendans, P. A., Dorn, G. W., FitzGerald, G. A., Hall, A. S., Hingorani, A. D., Hirschhorn, J. N., Hofker, M. H., Hovingh, K. G., Illig, T., Jamshidi, Y., Jarvik, G. P., Johnson, J. A., Kanetsky, P. A., Kastelein, J. J., Koenig, W., Lawlor, D. A., Marz, W., McCaffery, J., Mega, J. L., Mitchell, B. D., Murray, S. S., O'Connell, J. R., Patel, S. R., Peters, A., Pettinger, M., Rader, D. J., Redline, S., Reilly, M. P., Sabatine, M. S., Schadt, E. E., Shuldiner, A. R., Silverstein, R. L., Spector, T. D., Taylor, H. A., Thorand, B., Trip, M. D., Watkins, H., Wichmann, H.- E., Fox, C. S., Grant, S. F., Peter, I., Talmud, P. J., Munroe, P. B., Wilson, J. G., Knight, J. C., Samani, N. J., Hegele, R. A., Asselbergs, F. W., Monda, K. L., van der Schouw, Y. T., Demerath, E. W., Wijmenga, C., Timpson, N. J., Reiner, A. P., North, K. E., Papanicolaou, G. J., Lange , L. A., Keating , B. J.

Publikováno v: Human molecular genetics, 22(1), 184-201. Oxford University Press
Human Molecular Genetics
Hum. Mol. Genet. 22, 184-201 (2013)
Human Molecular Genetics; Vol 22

Recent genetic association studies have made progress in uncovering components of the genetic architecture of the body mass index (BMI). We used the ITMAT-Broad-Candidate Gene Association Resource (CARe) (IBC) array comprising up to 49 320 single nuc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0166578e352d396224c5a804613eb43e
https://pure.amc.nl/en/publications/genecentric-metaanalyses-of-108-912-individuals-confirm-known-body-mass-index-loci-and-reveal-three-novel-signals(cfdf63d4-bd63-48df-a043-b47d1a307f9f).html

Incidence and predictors of coronary heart disease among older African Americans--the Cardiovascular Health Study

Autor: Jackson, S. A., Burke, G. L., Thach, C., Cushman, M., Ives, D., Powe, N., Manolio, T. A.

Although coronary heart disease (CHD) is the leading cause of death and morbidity in older African Americans, relatively little is known about the incidence and predictors of CHD in this population. This study was undertaken to determine the incidenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::299e6bdab8c620e570f12beb055856dc
https://europepmc.org/articles/PMC2594007/

Changes in sexual behavior by young urban heterosexual adults in response to the AIDS epidemic

Autor: Melnick, S L, Jeffery, R W, Burke, G L, Gilbertson, D T, Perkins, L L, Sidney, S, McCreath, H E, Wagenknecht, L E, Hulley, S B

Young adults residing in four States were enrolled in the period 1985-88 in a multicenter study of cardiovascular disease risk factors. In 1989, 2,729 members of the group were given a self-administered questionnaire that included questions on change

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9cafd986b530591062f4f6387a6300c1
https://europepmc.org/articles/PMC1403434/

Pilot study of AIDS risk in the general population

Autor: Jeffery, R W, Burke, G L, Schmid, T L, Ma, J

This study evaluated a methodology for obtaining information on the prevalence of risk behaviors for human immunodeficiency virus infection (HIV) in the general population. From two census tracts in an upper midwestern urban community, 334 households

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc60d63ff829e73e5bc440c677104d6d
https://europepmc.org/articles/PMC1403610/