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of 7
pro vyhledávání: '"Burhan Jama"'
Autor:
Lu Wang, Christine Caron, Gerald P Morris, Hyun J Jang, Calvin K Lee, Burhan Jama, Jack D Bui
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Discovery that ~16% of T cells naturally co-express two T-cell receptor (TCR) clonotypes prompts examining the role of dual TCR cells in immune functions.Methods Using TCRα-reporter transgenic mice, enabling unambiguous identification of
Externí odkaz:
https://doaj.org/article/6ac1255386e54edca629c4ddd993ca59
Autor:
Hyun J Jang, Christine Caron, Calvin K Lee, Lu Wang, Burhan Jama, Jack D Bui, Gerald P Morris
Publikováno v:
Journal for immunotherapy of cancer, vol 11, iss 5
BackgroundDiscovery that ~16% of T cells naturally co-express two T-cell receptor (TCR) clonotypes prompts examining the role of dual TCR cells in immune functions.MethodsUsing TCRα-reporter transgenic mice, enabling unambiguous identification of si
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 51
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
It is known that a subpopulation of T cells expresses two T cell receptor (TCR) clonotypes, though the extent and functional significance of this is not established. To definitively evaluate dual TCRα cells, we generated mice with green fluorescent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28e9dbde220f253506f775e6be72577
https://escholarship.org/uc/item/2g04j9gs
https://escholarship.org/uc/item/2g04j9gs
Publikováno v:
The Journal of Immunology. 200:165.22-165.22
Generation of CD4+FoxP3+ regulatory T cells (Treg) in the thymus is essential for maintenance of self-tolerance. Treg lineage commitment occurs via agonist selection, via TCR high-affinity interaction with self-peptide-MHC (pMHC) ligand. We have prev
Autor:
Burhan Jama, Gerald P. Morris
Publikováno v:
Journal of Visualized Experiments.
The study of human T lymphocyte biology often involves examination of responses to activating ligands. T cells recognize and respond to processed peptide antigens presented by MHC (human ortholog HLA) molecules through the T cell receptor (TCR) in a
Publikováno v:
The Journal of Immunology. 198:215.9-215.9
Our laboratory studies how non-thymically selected secondary TCRs contribute to the T cell repertoire. We have previously demonstrated that peripheral T cells naturally expressing 2 TCRs have increased response to autoantigens. We hypothesized that t
Autor:
Nicholas J. Gloude, Amritha Balakrishnan, Eric Anderson, Edward D. Ball, Gerald P. Morris, Burhan Jama
Publikováno v:
Blood. 128:1156-1156
Evidence from clinical investigations and animal models indicate that chronic graft versus host disease (cGVHD) results from defective thymic generation of functional and self-tolerant T cell populations following hematopoietic stem cell transplantat