Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Burhan I, Ghanayem"'
Publikováno v:
Chem Res Toxicol
Acrylonitrile (ACN), which is a widely used industrial chemical, induces cancers in the mouse via unresolved mechanisms. For this report, complementary and previously described methods were used to assess in vivo genotoxicity and/or mutagenicity of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a5f3f025ea50051a8d3a4574fe0b27
https://europepmc.org/articles/PMC7477827/
https://europepmc.org/articles/PMC7477827/
Publikováno v:
International Journal of Toxicology. 30:551-561
This study determined the metabolism of 3 drinking water disinfection by-products (halogenated acetic acids [HAAs]), bromodichloroacetic acid (BDCAA), chlorodibromoacetic acid (CDBAA), and tribromoacetic acid (TBAA), using rat, mouse, human liver mic
Autor:
Burhan I. Ghanayem, Ralph E. Wilson, Undi Hoffler, Akef Rahman, Greg Travlos, Kristen Hobbie, David E. Malarkey, Re Bai
Publikováno v:
Endocrine. 36:311-325
Obesity and obesity-related illnesses are global epidemics impacting the health of adults and children. The purpose of the present work is to evaluate a genetically intact obese mouse model that more accurately reflects the impact of aging on diet-in
Autor:
C. Edwin Garner, Carol Sloan, Susan Sumner, James Davis, Burhan I. Ghanayem, Jason P. Burgess, A. Etheridge, A. Parham
Publikováno v:
Biology of Reproduction. 76:496-505
1-bromopropane (1-BrP) induces dose- and time-dependent reproductive organ toxicity and reduced sperm motility in rodents. The contribution of cytochrome P4502E1 (CYP2E1) to both 1-BrP metabolism and the induction of male reproductive toxicity was in
Autor:
Burhan I. Ghanayem
Publikováno v:
Toxicological Sciences. 95:331-339
Urethane is an established animal carcinogen and has been classified as "reasonably anticipated to be a human carcinogen." Until recently, urethane metabolism via esterase was considered the main metabolic pathway of this chemical. However, recent st
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 578:284-297
Acrylamide, an animal carcinogen and germ cell mutagen present at low (ppm) levels in heated carbohydrate-containing foodstuffs, is oxidized by cytochrome P4502E1 (CYP2E1) to the epoxide glycidamide, which is believed to be responsible for the mutage
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 313:302-309
Genetic variation in CYP3A activity may influence the rate of the metabolism and elimination of CYP3A substrates in humans. We previously reported four new CYP3A4 coding variants in three different racial groups. In the present study, we examined met
Autor:
Michael D. Shelby, Kristine L. Witt, Burhan I. Ghanayem, Undi Hoffler, Grace E. Kissling, Jack B. Bishop, L. El-Hadri
Publikováno v:
Biology of Reproduction. 72:157-163
Acrylamide is an animal carcinogen and probable human carcinogen present in appreciable amounts in heated carbohydrate-rich foodstuffs. It is also a germ cell mutagen, inducing dominant lethal mutations and heritable chromosomal translocations in pos
Autor:
Burhan I. Ghanayem, Garold S. Yost, Ashish Sharma, Christopher A. Reilly, Andrea C. Simmonds, Brandie Millen, Poh Gek Forkert
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 310:855-864
1,1-Dichloroethylene (DCE) exposure evokes lung toxicity with selective damage to bronchiolar Clara cells. Recent in vitro studies have implicated CYP2E1 and CYP2F2 in the bioactivation of DCE to 2-S-glutathionyl acetate [C], a putative conjugate of
Publikováno v:
Toxicology and Applied Pharmacology. 193:293-302
Acrylonitrile (AN) is a potent toxicant and a known rodent carcinogen. AN epoxidation to cyanoethylene oxide (CEO) via CYP2E1 and its subsequent metabolism via epoxide hydrolases (EH) to yield cyanide is thought to be responsible for the acute toxici