Výsledky vyhledávání - "Burgoyne Robert D"

Akademický článek

Identification of common genetic modifiers of neurodegenerative diseases from an integrative analysis of diverse genetic screens in model organisms

Autor: Chen Xi, Burgoyne Robert D

Publikováno v: BMC Genomics, Vol 13, Iss 1, p 71 (2012)

Abstract Background An array of experimental models have been developed in the small model organisms C. elegans, S. cerevisiae and D. melanogaster for the study of various neurodegenerative diseases including Alzheimer's disease, Parkinson's disease,

Externí odkaz: https://doaj.org/article/60cc7d12b0ef41379a377454770d4d2f

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Akademický článek

Understanding the physiological roles of the neuronal calcium sensor proteins

Autor: Burgoyne Robert D, Haynes Lee P

Publikováno v: Molecular Brain, Vol 5, Iss 1, p 2 (2012)

Abstract Calcium signalling plays a crucial role in the control of neuronal function and plasticity. Changes in neuronal Ca2+ concentration are detected by Ca2+-binding proteins that can interact with and regulate target proteins to modify their func

Externí odkaz: https://doaj.org/article/3b3ad52109d945ed97ca4706eb0c2824

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Akademický článek

Bioinformatic analysis of CaBP/calneuron proteins reveals a family of highly conserved vertebrate Ca2+-binding proteins

Autor: Burgoyne Robert D, Haynes Lee P, McCue Hannah V

Publikováno v: BMC Research Notes, Vol 3, Iss 1, p 118 (2010)

Abstract Background Ca2+-binding proteins are important for the transduction of Ca2+ signals into physiological outcomes. As in calmodulin many of the Ca2+-binding proteins bind Ca2+ through EF-hand motifs. Amongst the large number of EF-hand contain

Externí odkaz: https://doaj.org/article/a07a4119ab054cb7ad0ae569a2e37b56

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Akademický článek

Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding

Autor: Lovestone Simon, Suzuki Toshiharu, Buxbaum Joseph D, Benson Lyndsey S, Pedrini Steve, Causevic Mirsada, Ikin Annat F, Higashiyama Shigeki, Mustelin Tomas, Burgoyne Robert D, Gandy Sam

Publikováno v: Molecular Neurodegeneration, Vol 2, Iss 1, p 23 (2007)

Abstract Background Shedding of the Alzheimer amyloid precursor protein (APP) ectodomain can be accelerated by phorbol esters, compounds that act via protein kinase C (PKC) or through unconventional phorbol-binding proteins such as Munc13-1. We have

Externí odkaz: https://doaj.org/article/f6b2116bd4c04cfb8584ad785cef1d39

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