Zobrazeno 1 - 10
of 488
pro vyhledávání: '"Burgess, B. A."'
Autor:
Marc Zuckermann, Chen He, Jared Andrews, Aditi Bagchi, Roketa Sloan-Henry, Brandon Bianski, Jia Xie, Yingzhe Wang, Nathaniel Twarog, Arzu Onar-Thomas, Kati J. Ernst, Lei Yang, Yong Li, Xiaoyan Zhu, Jennifer K. Ocasio, Kaitlin M. Budd, James Dalton, Xiaoyu Li, Divyabharathi Chepyala, Junyuan Zhang, Ke Xu, Laura Hover, Jordan T. Roach, Kenneth Chun-Ho Chan, Nina Hofmann, Peter J. McKinnon, Stefan M. Pfister, Anang A. Shelat, Zoran Rankovic, Burgess B. Freeman, Jason Chiang, David T. W. Jones, Christopher L. Tinkle, Suzanne J. Baker
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-19 (2024)
Abstract Background Pediatric-type diffuse high-grade glioma (pHGG) is the most frequent malignant brain tumor in children and can be subclassified into multiple entities. Fusion genes activating the MET receptor tyrosine kinase often occur in infant
Externí odkaz:
https://doaj.org/article/c4e30eaef7d54080a0db2c1628bcebbf
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition
Autor:
Noha A. M. Shendy, Melissa Bikowitz, Logan H. Sigua, Yang Zhang, Audrey Mercier, Yousef Khashana, Stephanie Nance, Qi Liu, Ian M. Delahunty, Sarah Robinson, Vanshita Goel, Matthew G. Rees, Melissa A. Ronan, Tingjian Wang, Mustafa Kocak, Jennifer A. Roth, Yingzhe Wang, Burgess B. Freeman, Brent A. Orr, Brian J. Abraham, Martine F. Roussel, Ernst Schonbrunn, Jun Qi, Adam D. Durbin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Chemical discovery efforts commonly target individual protein domains. Many proteins, including the EP300/CBP histone acetyltransferases (HATs), contain several targetable domains. EP300/CBP are critical gene-regulatory targets in cancer, wi
Externí odkaz:
https://doaj.org/article/398968e4bfb8412fb2122ae3a754c4c5
Autor:
Keenan, Camille, Albeituni, Sabrin, Oak, Ninad, Stroh, Alexa, Tillman, Heather S., Wang, Yingzhe, Freeman, Burgess B., III, Alemán-Arteaga, Silvia, Meyer, Lauren K., Woods, Rolanda, Verbist, Katherine C., Zhou, Yinmei, Cheng, Cheng, Nichols, Kim E.
Publikováno v:
In Blood 6 June 2024 143(23):2386-2400
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Min Pan, William C. Wright, Richard H. Chapple, Asif Zubair, Manbir Sandhu, Jake E. Batchelder, Brandt C. Huddle, Jonathan Low, Kaley B. Blankenship, Yingzhe Wang, Brittney Gordon, Payton Archer, Samuel W. Brady, Sivaraman Natarajan, Matthew J. Posgai, John Schuetz, Darcie Miller, Ravi Kalathur, Siquan Chen, Jon Patrick Connelly, M. Madan Babu, Michael A. Dyer, Shondra M. Pruett-Miller, Burgess B. Freeman, Taosheng Chen, Lucy A. Godley, Scott C. Blanchard, Elizabeth Stewart, John Easton, Paul Geeleher
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
CX-5461 recently progressed through phase I clinical trial as a first-inhuman inhibitor of RNA-POL I. Here, the authors demonstrate that CX-5461 synergizes with topoisomerase I inhibitors to inhibit neuroblastoma cells and that its primary target in
Externí odkaz:
https://doaj.org/article/eab356ebc3d24e3c88297e4fc7fbc176
Autor:
Barthelemy Diouf, Claudia Wing, John C. Panetta, Donnie Eddins, Wenwei Lin, Wenjian Yang, Yiping Fan, Deqing Pei, Cheng Cheng, Shannon M. Delaney, Wei Zhang, Erik J. Bonten, Kristine R. Crews, Steven W. Paugh, Lie Li, Burgess B. Freeman 3rd, Robert J. Autry, Jordan A. Beard, Daniel C. Ferguson, Laura J. Janke, Kirsten K. Ness, Taosheng Chen, Stanislav S. Zakharenko, Sima Jeha, Ching‐Hon Pui, Mary V. Relling, M. Eileen Dolan, William E. Evans
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 4, Pp 1490-1504 (2021)
Abstract Vincristine (VCR) is one of the most widely prescribed medications for treating solid tumors and acute lymphoblastic leukemia (ALL) in children and adults. However, its major dose‐limiting toxicity is peripheral neuropathy that can disrupt
Externí odkaz:
https://doaj.org/article/e3e40089bb0343279b5f3003e28e87aa
Autor:
Chen He, Ke Xu, Xiaoyan Zhu, Paige S. Dunphy, Brian Gudenas, Wenwei Lin, Nathaniel Twarog, Laura D. Hover, Chang-Hyuk Kwon, Lawryn H. Kasper, Junyuan Zhang, Xiaoyu Li, James Dalton, Barbara Jonchere, Kimberly S. Mercer, Duane G. Currier, William Caufield, Yingzhe Wang, Jia Xie, Alberto Broniscer, Cynthia Wetmore, Santhosh A. Upadhyaya, Ibrahim Qaddoumi, Paul Klimo, Frederick Boop, Amar Gajjar, Jinghui Zhang, Brent A. Orr, Giles W. Robinson, Michelle Monje, Burgess B. Freeman III, Martine F. Roussel, Paul A. Northcott, Taosheng Chen, Zoran Rankovic, Gang Wu, Jason Chiang, Christopher L. Tinkle, Anang A. Shelat, Suzanne J. Baker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Patient-derived xenografts provide a resource for basic and translational cancer research. Here, the authors generate multiple pediatric high-grade glioma xenografts, use omics technologies to show that they are representative of primary tumours and
Externí odkaz:
https://doaj.org/article/879be8929790465bbe548678fef6db02
Autor:
Iacobucci, Ilaria *, Qu, Chunxu *, Varotto, Elena, Janke, Laura J., Yang, Xu, Seth, Aman, Shelat, Anang, Friske, Jake D., Fukano, Reiji, Yu, Jiyang, Freeman, Burgess B., III, Kennedy, James A., Sperling, Adam S., Zheng, Rena, Wang, Yingzhe, Jogiraju, Harini, Dickerson, Kirsten M., Payne-Turner, Debbie, Morris, Sarah M., Hollis, Emily S., Ghosn, Nina, Haggard, Georgia E., Lindsley, R. Coleman, Ebert, Benjamin L., Mullighan, Charles G. *
Publikováno v:
In Blood 25 March 2021 137(12):1628-1640