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pro vyhledávání: '"Burdon, Abigail"'
Background: Drug development is often inefficient, costly and lengthy, yet it is essential for evaluating the safety and efficacy of new interventions. Compared with other disease areas, this is particularly true for Phase II / III cancer clinical tr
Externí odkaz:
http://arxiv.org/abs/2405.06353
Autor:
Burdon, Abigail J., Jaki, Thomas
We describe group sequential tests which efficiently incorporate information from multiple endpoints allowing for early stopping at pre-planned interim analyses. We formulate a testing procedure where several outcomes are examined, and interim decisi
Externí odkaz:
http://arxiv.org/abs/2405.05139
The use of the non-parametric Restricted Mean Survival Time endpoint (RMST) has grown in popularity as trialists look to analyse time-to-event outcomes without the restrictions of the proportional hazards assumption. In this paper, we evaluate the po
Externí odkaz:
http://arxiv.org/abs/2311.01872
Adaptive enrichment allows for pre-defined patient subgroups of interest to be investigated throughout the course of a clinical trial. Many trials which measure a long-term time-to-event endpoint often also routinely collect repeated measures on biom
Externí odkaz:
http://arxiv.org/abs/2301.10640
Often in Phase 3 clinical trials measuring a long-term time-to-event endpoint, such as overall survival or progression-free survival, investigators also collect repeated measures on biomarkers which may be predictive of the primary endpoint. Although
Externí odkaz:
http://arxiv.org/abs/2211.16138
Publikováno v:
In European Journal of Cancer August 2023 189
Akademický článek
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Akademický článek
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Autor:
Burdon, Abigail J1 (AUTHOR) abigail.burdon@mrc-bsu.cam.ac.uk, Baird, Richard D2 (AUTHOR), Jaki, Thomas1,3 (AUTHOR)
Publikováno v:
Statistical Methods in Medical Research. Oct2024, p1.