ERK1/2 Phosphorylation Predicts Survival in Recurrent Glioblastoma Following Intracerebral and Adjuvant PD-1/CTLA-4 Immunotherapy: A REMARK-guided Analysis.

Autor: Arrieta VA; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Chicago, Illinois., Duerinck J; Department of Neurosurgery, Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium., Burdett KB; Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois., Habashy KJ; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Chicago, Illinois., Geens W; Department of Neurosurgery, Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium., Gould A; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Chicago, Illinois., Schwarze JK; Department of Medical Oncology, Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium., Dmello C; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Chicago, Illinois., Kim KS; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Chicago, Illinois., Saganty R; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Chicago, Illinois., Chen L; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Chicago, Illinois., Moscona A; Facultad de Ciencias de la Salud, Escuela de Medicina Universidad Panamericana, Mexico City, Mexico., McCord M; Department of Pathology, Division of Neuropathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois., Lee-Chang C; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Chicago, Illinois., Horbinski CM; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Chicago, Illinois.; Department of Pathology, Division of Neuropathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois., Zhang H; Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois., Stupp R; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Chicago, Illinois.; Department of Medicine, Division of Hematology and Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois., Neyns B; Department of Medical Oncology, Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium., Sonabend AM; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Chicago, Illinois.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Jan 17; Vol. 30 (2), pp. 379-388.

Determining venous thromboembolism risk in patients with adult-type diffuse glioma.

Autor: Burdett KB; Department of Preventive Medicine, Northwestern University, Chicago, IL., Unruh D; Bio-Techne, Minneapolis, MN., Drumm M; Department of Neurological Surgery, Northwestern University, Chicago, IL.; Lou and Jean Malnati Brain Tumor Institute of the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL., Steffens A; Department of Neurological Surgery, Northwestern University, Chicago, IL.; Lou and Jean Malnati Brain Tumor Institute of the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL., Lamano J; Department of Neurosurgery, Stanford University, Stanford, CA., Judkins J; Department of Medicine, Oregon Health and Science University, Portland, OR., Schwartz M; Department of Neurological Surgery, Northwestern University, Chicago, IL.; Lou and Jean Malnati Brain Tumor Institute of the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL., Javier R; University of Chicago Pritzker School of Medicine, Chicago, IL., Amidei C; Department of Neurological Surgery, Northwestern University, Chicago, IL.; Lou and Jean Malnati Brain Tumor Institute of the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL., Lipp ES; The Preston Robert Tisch Brain Tumor Center, Department of Neurosurgery, Duke University Medical Center, Durham, NC., Peters KB; The Preston Robert Tisch Brain Tumor Center, Department of Neurosurgery, Duke University Medical Center, Durham, NC., Lai A; Department of Neurology, University of California, Los Angeles, CA., Eldred BSC; Department of Neurology, University of California, Los Angeles, CA., Heimberger AB; Department of Neurological Surgery, Northwestern University, Chicago, IL.; Lou and Jean Malnati Brain Tumor Institute of the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL., McCortney K; Department of Neurological Surgery, Northwestern University, Chicago, IL.; Lou and Jean Malnati Brain Tumor Institute of the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL., Scholtens DM; Department of Preventive Medicine, Northwestern University, Chicago, IL., Horbinski C; Department of Neurological Surgery, Northwestern University, Chicago, IL.; Lou and Jean Malnati Brain Tumor Institute of the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL.; Department of Pathology, Northwestern University, Chicago, IL.

Publikováno v: Blood [Blood] 2023 Mar 16; Vol. 141 (11), pp. 1322-1336.

ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma.

Autor: Arrieta VA; Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; PECEM, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico., Chen AX; Program for Mathematical Genomics, Department of Systems Biology, Columbia University, New York, NY, USA., Kane JR; Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Kang SJ; Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Kassab C; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dmello C; Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Zhao J; Program for Mathematical Genomics, Department of Systems Biology, Columbia University, New York, NY, USA.; Department of Biomedical Informatics, Columbia University, New York, NY, USA., Burdett KB; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Upadhyayula PS; Department of Neurosurgery, Columbia University, New York, NY, USA., Lee-Chang C; Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Shilati J; Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Jaishankar D; Robert Lurie Comprehensive Cancer Center and Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Chen L; Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Gould A; Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Zhang D; Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Yuan J; Department of Biomedical Informatics, Columbia University, New York, NY, USA., Zhao W; Department of Biomedical Informatics, Columbia University, New York, NY, USA., Ling X; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Burks JK; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Laffleur B; INSERM U1236, University of Rennes 1, Etablissement Français du Sang, Rennes, France., Amidei C; Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Bruce JN; Department of Neurosurgery, Columbia University, New York, NY, USA., Lukas RV; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Yamaguchi JT; Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Cieremans D; Department of Neurology, Columbia University, Vagelos College of Physicians and Surgeons Columbia University Irving Medical Center, New York, NY, USA., Rothschild G; Department of Microbiology and Immunology, Columbia University, New York, NY, USA., Basu U; Department of Microbiology and Immunology, Columbia University, New York, NY, USA., McCord M; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Brat DJ; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Zhang H; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Cooper LAD; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Zhang B; Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Sims P; Department of Biomedical Informatics, Columbia University, New York, NY, USA., Cloughesy TF; Department of Medical and Molecular Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Prins R; Department of Medical and Molecular Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Canoll P; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA., Stupp R; Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Heimberger AB; Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Horbinski C; Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Iwamoto FM; Department of Neurology, Columbia University, Vagelos College of Physicians and Surgeons Columbia University Irving Medical Center, New York, NY, USA. fi2146@cumc.columbia.edu., Rabadan R; Program for Mathematical Genomics, Department of Systems Biology, Columbia University, New York, NY, USA. rr2579@cumc.columbia.edu.; Department of Biomedical Informatics, Columbia University, New York, NY, USA. rr2579@cumc.columbia.edu., Sonabend AM; Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. adam.sonabend@northwestern.edu.

Publikováno v: Nature cancer [Nat Cancer] 2021 Dec; Vol. 2 (12), pp. 1372-1386. Date of Electronic Publication: 2021 Nov 29.

Ribosomal protein S11 influences glioma response to TOP2 poisons.

Autor: Awah CU; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University , Chicago, IL, United States., Chen L; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University , Chicago, IL, United States., Bansal M; Psychogenic Inc., Paramus, NJ, USA., Mahajan A; Department of Neurological Surgery, Columbia University Medical Center, Columbia University, New York City, NY, USA., Winter J; Functional Genomics and Signaling, German Center for Cancer Research, Heidelberg, Germany., Lad M; Mailman School of Public Health, Columbia University, New York City, NY, USA., Warnke L; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University , Chicago, IL, United States., Gonzalez-Buendia E; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University , Chicago, IL, United States., Park C; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University , Chicago, IL, United States., Zhang D; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University , Chicago, IL, United States., Feldstein E; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University , Chicago, IL, United States., Yu D; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University , Chicago, IL, United States., Zannikou M; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University , Chicago, IL, United States., Balyasnikova IV; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University , Chicago, IL, United States., Martuscello R; Department of Pathology, Columbia University Medical Centre, Columbia University, New York City, NY, USA., Konerman S; Molecular and Cell Biology, Salk Institute, La Jolla, CA, USA., Győrffy B; MTA TTK Lendület Cancer Biomarker Research Group, Institute of Enzymology, Hungarian Academy of Sciences, Budapest, Hungary.; 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary., Burdett KB; Department of Preventive Medicine, Northwestern University, Chicago, IL, USA., Scholtens DM; Department of Preventive Medicine, Northwestern University, Chicago, IL, USA., Stupp R; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University , Chicago, IL, United States., Ahmed A; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University , Chicago, IL, United States., Hsu P; Molecular and Cell Biology, Salk Institute, La Jolla, CA, USA., Sonabend AM; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University , Chicago, IL, United States. adam.sonabend@nm.org.

Publikováno v: Oncogene [Oncogene] 2020 Jul; Vol. 39 (27), pp. 5068-5081. Date of Electronic Publication: 2020 Jun 11.