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Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1)

Autor: Palackal, N. T., Burczynski, M. E., Harvey, R. G., Penning, T. M.

Publikováno v: Chemico-Biological Interactions; 2001, Vol. 130 Issue: 1 p815-824, 10p

The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation.

Autor: Palackal NT; Department of Biochemistry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA., Burczynski ME, Harvey RG, Penning TM

Publikováno v: Biochemistry [Biochemistry] 2001 Sep 11; Vol. 40 (36), pp. 10901-10.

Cytochrome P450 induction in rat hepatocytes assessed by quantitative real-time reverse-transcription polymerase chain reaction and the RNA invasive cleavage assay.

Autor: Burczynski ME; Department of Pre-Clinical Drug Metabolism and Toxicology, The R. W. Johnson Pharmaceutical Research Institute, Ortho McNeil Pharmaceutical Building, Route 202, Raritan, New Jersey 08869, USA., McMillian M, Parker JB, Bryant S, Leone A, Grant ER, Thorne JM, Zhong Z, Zivin RA, Johnson MD

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2001 Sep; Vol. 29 (9), pp. 1243-50.

Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells.

Autor: Burczynski ME; Drug Safety Evaluation, Robert Wood Johnson Pharmaceutical Research Institute, P.O. Box 300, Route 202, Raritan, New Jersey 08869, USA., McMillian M, Ciervo J, Li L, Parker JB, Dunn RT 2nd, Hicken S, Farr S, Johnson MD

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2000 Dec; Vol. 58 (2), pp. 399-415.