Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Burcu F Darst"'
Autor:
Donghui Yan, Bowen Hu, Burcu F Darst, Shubhabrata Mukherjee, Brian W Kunkle, Yuetiva Deming, Logan Dumitrescu, Yunling Wang, Adam Naj, Amanda Kuzma, Yi Zhao, Hyunseung Kang, Sterling C Johnson, Cruchaga Carlos, Timothy J Hohman, Paul K Crane, Corinne D Engelman, Alzheimer’s Disease Genetics Consortium (ADGC), Qiongshi Lu
Publikováno v:
eLife, Vol 12 (2024)
Rich data from large biobanks, coupled with increasingly accessible association statistics from genome-wide association studies (GWAS), provide great opportunities to dissect the complex relationships among human traits and diseases. We introduce BAD
Externí odkaz:
https://doaj.org/article/70e5d04b97aa44e69655821a17499202
Autor:
Fei Chen, Burcu F Darst, Ravi K Madduri, Alex A Rodriguez, Xin Sheng, Christopher T Rentsch, Caroline Andrews, Wei Tang, Adam S Kibel, Anna Plym, Kelly Cho, Mohamed Jalloh, Serigne Magueye Gueye, Lamine Niang, Olufemi J Ogunbiyi, Olufemi Popoola, Akindele O Adebiyi, Oseremen I Aisuodionoe-Shadrach, Hafees O Ajibola, Mustapha A Jamda, Olabode P Oluwole, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, James E Mensah, Andrew Anthony Adjei, Halimatou Diop, Joseph Lachance, Timothy R Rebbeck, Stefan Ambs, J Michael Gaziano, Amy C Justice, David V Conti, Christopher A Haiman
Publikováno v:
eLife, Vol 11 (2022)
Background: We recently developed a multi-ancestry polygenic risk score (PRS) that effectively stratifies prostate cancer risk across populations. In this study, we validated the performance of the PRS in the multi-ancestry Million Veteran Program an
Externí odkaz:
https://doaj.org/article/357704951c834856af7fc63a759e4c2d
Autor:
Samantha A Streicher, Unhee Lim, S Lani Park, Yuqing Li, Xin Sheng, Victor Hom, Lucy Xia, Loreall Pooler, John Shepherd, Lenora W M Loo, Burcu F Darst, Heather M Highland, Linda M Polfus, David Bogumil, Thomas Ernst, Steven Buchthal, Adrian A Franke, Veronica Wendy Setiawan, Maarit Tiirikainen, Lynne R Wilkens, Christopher A Haiman, Daniel O Stram, Iona Cheng, Loïc Le Marchand
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0249615 (2021)
Several studies have found associations between higher pancreatic fat content and adverse health outcomes, such as diabetes and the metabolic syndrome, but investigations into the genetic contributions to pancreatic fat are limited. This genome-wide
Externí odkaz:
https://doaj.org/article/b361d70db41041cbb12d5be579e444fb
Autor:
Kangcheng Hou, Yi Ding, Ziqi Xu, Yue Wu, Arjun Bhattacharya, Rachel Mester, Gillian M. Belbin, Steve Buyske, David V. Conti, Burcu F. Darst, Myriam Fornage, Chris Gignoux, Xiuqing Guo, Christopher Haiman, Eimear E. Kenny, Michelle Kim, Charles Kooperberg, Leslie Lange, Ani Manichaikul, Kari E. North, Ulrike Peters, Laura J. Rasmussen-Torvik, Stephen S. Rich, Jerome I. Rotter, Heather E. Wheeler, Genevieve L. Wojcik, Ying Zhou, Sriram Sankararaman, Bogdan Pasaniuc
Publikováno v:
Nature Genetics. 55:549-558
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee5d8c5855ec7380bbc5edffa613a826
https://doi.org/10.1038/s41588-023-01338-6
https://doi.org/10.1038/s41588-023-01338-6
Autor:
Andrea M. Johnson, Deanna Teoh, Patricia Jewett, Burcu F. Darst, Jordan Mattson, Cody Hoffmann, Katherine Brown, Aditi Makaram, Ciana Keller, Anne H. Blaes, Susan A. Everson-Rose, Rachel I. Vogel
Publikováno v:
Gynecologic Oncology. 170:102-107
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::936f1938c1f713308298baf61064bd24
https://doi.org/10.1016/j.ygyno.2023.01.006
https://doi.org/10.1016/j.ygyno.2023.01.006
Publikováno v:
BMC Genetics, Vol 19, Iss S1, Pp 1-6 (2018)
Abstract Background Random forest (RF) is a machine-learning method that generally works well with high-dimensional problems and allows for nonlinear relationships between predictors; however, the presence of correlated predictors has been shown to i
Externí odkaz:
https://doaj.org/article/c9e7b48bfbc14afb95f76355f8eace7a
Autor:
Christopher A. Haiman, David V. Conti, Hans Lilja, Loïc Le Marchand, Lynne R. Wilkens, Burcu F. Darst, Alisha Chou
Supplementary Figure from Association of Prostate-Specific Antigen Levels with Prostate Cancer Risk in a Multiethnic Population: Stability Over Time and Comparison with Polygenic Risk Score
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc39e8ca78114d7ca31ca3f265addb7
https://doi.org/10.1158/1055-9965.23099356
https://doi.org/10.1158/1055-9965.23099356
Autor:
Christopher A. Haiman, David V. Conti, Hans Lilja, Loïc Le Marchand, Lynne R. Wilkens, Burcu F. Darst, Alisha Chou
Background:Studies in men of European ancestry suggest prostate-specific antigen (PSA) as a marker of early prostate cancer development that may help to risk-stratify men earlier in life.Methods:We examined PSA levels in men measured up to 10+ years
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77430d7b09fd5580774d2202e9bbc60e
https://doi.org/10.1158/1055-9965.c.6660313
https://doi.org/10.1158/1055-9965.c.6660313
Autor:
Fei Chen, Ravi K. Madduri, Alex A. Rodriguez, Burcu F. Darst, Alisha Chou, Xin Sheng, Anqi Wang, Jiayi Shen, Edward J. Saunders, Suhn K. Rhie, Jeannette T. Bensen, Sue A. Ingles, Rick A. Kittles, Sara S. Strom, Benjamin A. Rybicki, Barbara Nemesure, William B. Isaacs, Janet L. Stanford, Wei Zheng, Maureen Sanderson, Esther M. John, Jong Y. Park, Jianfeng Xu, Ying Wang, Sonja I. Berndt, Chad D. Huff, Edward D. Yeboah, Yao Tettey, Joseph Lachance, Wei Tang, Christopher T. Rentsch, Kelly Cho, Benjamin H. Mcmahon, Richard B. Biritwum, Andrew A. Adjei, Evelyn Tay, Ann Truelove, Shelley Niwa, Thomas A. Sellers, Kosj Yamoah, Adam B. Murphy, Dana C. Crawford, Alpa V. Patel, William S. Bush, Melinda C. Aldrich, Olivier Cussenot, Gyorgy Petrovics, Jennifer Cullen, Christine M. Neslund-Dudas, Mariana C. Stern, Zsofia Kote-Jarai, Koveela Govindasami, Michael B. Cook, Anand P. Chokkalingam, Ann W. Hsing, Phyllis J. Goodman, Thomas J. Hoffmann, Bettina F. Drake, Jennifer J. Hu, Jacob M. Keaton, Jacklyn N. Hellwege, Peter E. Clark, Mohamed Jalloh, Serigne M. Gueye, Lamine Niang, Olufemi Ogunbiyi, Michael O. Idowu, Olufemi Popoola, Akindele O. Adebiyi, Oseremen I. Aisuodionoe-Shadrach, Hafees O. Ajibola, Mustapha A. Jamda, Olabode P. Oluwole, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, James E. Mensah, Halimatou Diop, Stephen K. Van Den Eeden, Pascal Blanchet, Jay H. Fowke, Graham Casey, Anselm J. Hennis, Alexander Lubwama, Ian M. Thompson, Robin Leach, Douglas F. Easton, Michael H. Preuss, Ruth J. Loos, Susan M. Gundell, Peggy Wan, James L. Mohler, Elizabeth T. Fontham, Gary J. Smith, Jack A. Taylor, Shiv Srivastava, Rosaline A. Eeles, John D. Carpten, Adam S. Kibel, Luc Multigner, Marie-Élise Parent, Florence Menegaux, Geraldine Cancel-Tassin, Eric A. Klein, Caroline Andrews, Timothy R. Rebbeck, Laurent Brureau, Stefan Ambs, Todd L. Edwards, Stephen Watya, Stephen J. Chanock, John S. Witte, William J. Blot, J. Michael Gaziano, Amy C. Justice, David V. Conti, Christopher A. Haiman
Publikováno v:
European Urology
European Urology, 2023, 84 (1), pp.13-21. ⟨10.1016/j.eururo.2023.01.022⟩
European Urology, 2023, 84 (1), pp.13-21. ⟨10.1016/j.eururo.2023.01.022⟩
Background: Genetic factors play an important role in prostate cancer (PCa) susceptibility.Objective: To discover common genetic variants contributing to the risk of PCa in men of African ancestry.Design, setting, and participants: We conducted a met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b42ff56b071fb413155ed348022ab4c
https://doi.org/10.1016/j.eururo.2023.01.022
https://doi.org/10.1016/j.eururo.2023.01.022
Autor:
Anqi Wang, Yili Xu, Yao Yu, Kevin T Nead, TaeBeom Kim, Keren Xu, Tokhir Dadaev, Ed Saunders, Xin Sheng, Peggy Wan, Loreall Pooler, Lucy Y Xia, Stephen Chanock, Sonja I Berndt, Susan M Gapstur, Victoria Stevens, Demetrius Albanes, Stephanie J Weinstein, Vincent Gnanapragasam, Graham G Giles, Tu Nguyen-Dumont, Roger L Milne, Mark M Pomerantz, Julie A Schmidt, Konrad H Stopsack, Lorelei A Mucci, William J Catalona, Kurt N Hetrick, Kimberly F Doheny, Robert J MacInnis, Melissa C Southey, Rosalind A Eeles, Fredrik Wiklund, Zsofia Kote-Jarai, Adam J de Smith, David V Conti, Chad Huff, Christopher A Haiman, Burcu F Darst
Publikováno v:
Wang, A, Xu, Y, Yu, Y, Nead, K T, Kim, T B, Xu, K, Dadaev, T, Saunders, E, Sheng, X, Wan, P, Pooler, L, Xia, L Y, Chanock, S, Berndt, S I, Gapstur, S M, Stevens, V, Albanes, D, Weinstein, S J, Gnanapragasam, V, Giles, G G, Nguyen-Dumont, T, Milne, R L, Pomerantz, M M, Schmidt, J A, Stopsack, K H, Mucci, L A, Catalona, W J, Hetrick, K N, Doheny, K F, MacInnis, R J, Southey, M C, Eeles, R A, Wiklund, F, Kote-Jarai, Z, de Smith, A J, Conti, D V, Huff, C, Haiman, C A & Darst, B F 2023, ' Clonal hematopoiesis and risk of prostate cancer in large samples of European ancestry men ', Human Molecular Genetics, vol. 32, no. 3, pp. 489-495 . https://doi.org/10.1093/hmg/ddac214
Little is known regarding the potential relationship between clonal hematopoiesis (CH) of indeterminate potential (CHIP), which is the expansion of hematopoietic stem cells with somatic mutations, and risk of prostate cancer, the fifth leading cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4741fc3a448342e6e513e658f66c2b0f
https://pure.au.dk/portal/da/publications/clonal-hematopoiesis-and-risk-of-prostate-cancer-in-large-samples-of-european-ancestry-men(e0777d6d-3f9f-45e2-875b-233cbc32b981).html
https://pure.au.dk/portal/da/publications/clonal-hematopoiesis-and-risk-of-prostate-cancer-in-large-samples-of-european-ancestry-men(e0777d6d-3f9f-45e2-875b-233cbc32b981).html