Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention

Autor: Jack D. Adderley, Simona John von Freyend, Sarah A. Jackson, Megan J. Bird, Amy L. Burns, Burcu Anar, Tom Metcalf, Jean-Philippe Semblat, Oliver Billker, Danny W. Wilson, Christian Doerig

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Plasmodium infection activates signaling pathways in a-nucleated erythrocytes. Here, Adderley et al. use a comprehensive antibody microarray to show that infection extensively modulates host cell signalling and that the host receptor tyrosine kinase

Externí odkaz: https://doaj.org/article/2184f8c6d5224440bbad4ee6681c855d

An enhanced toolkit for the generation of knockout and marker-free fluorescent Plasmodium chabaudi [version 1; peer review: 2 approved]

Autor: Edward J Marr, Rachel M Milne, Burcu Anar, Gareth Girling, Frank Schwach, Jason P Mooney, Wiebke Nahrendorf, Philip J Spence, Deirdre Cunningham, David A Baker, Jean Langhorne, Julian C Rayner, Oliver Billker, Ellen S Bushell, Joanne Thompson

Publikováno v: Wellcome Open Research, Vol 5 (2020)

The rodent parasite Plasmodium chabaudi is an important in vivo model of malaria. The ability to produce chronic infections makes it particularly useful for investigating the development of anti-Plasmodium immunity, as well as features associated wit

Externí odkaz: https://doaj.org/article/73142696bd304da193f9a5f512b43ee3

Landscape of the Plasmodium Interactome

Autor: Burcu Anar, Theo Sanderson, Colin Herd, Julian C. Rayner, Jyoti S. Choudhary, Tom Metcalf, Oliver Billker, Lu Yu, Charles Hillier, Mercedes Pardo Calvo, Ellen Bushell

Publikováno v: SSRN Electronic Journal.

Malaria represents a major global health issue, and the identification and prioritisation of new intervention targets remains an urgent priority. This search is significantly hampered by the fact that over a third of the genes of the malaria-causing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9eb7a135ff3a5c94c109a7645089045d
https://doi.org/10.2139/ssrn.3314563

A scalable pipeline for highly effective genetic modification of a malaria parasite

Autor: Arnab Pain, Claudia Pfander, Michael A. Quail, Frank Schwach, William C. Skarnes, Katrin Volkmann, Julian C. Rayner, Barry Rosen, Mathieu Brochet, Thomas D. Otto, Oliver Billker, Burcu Anar

Publikováno v: Nature Methods; Vol 8
Nature methods

In malaria parasites, the systematic experimental validation of drug and vaccine targets by reverse genetics is constrained by the inefficiency of homologous recombination and by the difficulty of manipulating adenine and thymine (A+T)-rich DNA of mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0793b1b04bd39682800ef96b025c8c7c
https://doi.org/10.1038/nmeth.1742

Distinct genetic forms of frontotemporal dementia

Autor: Sonia M. Rosso, Dennis Dooijes, J. C. van Swieten, Wouter Kamphorst, Harro Seelaar, Burcu Anar, J. A. Maat-Kievit, I. de Koning, Guido J. Breedveld, Iraad F. Bronner, Patrizia Rizzu, L. Donker Kaat, J. M. Rozemuller, R. Masdjedi, Asma Azmani

Publikováno v: Neurology, 71(16), 1220-1226. Lippincott Williams & Wilkins
Neurology, 71(16), 1220-1226. Lippincott Williams and Wilkins
Seelaar, H, Kamphorst, W, Rosso, S M, Azmani, A, Masdjedi, R, de Koning, I, Maat-Kievit, J A, Anar, B, Kaat, L D, Breedveld, G J, Dooijes, D, Rozemuller, A J M, Bronner, I F, Rizzu, P & van Swieten, J C 2008, ' Distinct genetic forms of frontotemporal dementia ', Neurology, vol. 71, no. 16, pp. 1220-1226 . https://doi.org/10.1212/01.wnl.0000319702.37497.72

Background: Frontotemporal dementia (FTD) is the second most common type of presenile dementia and can be distinguished into various clinical variants. The identification of MAPT and GRN defects and the discovery of the TDP-43 protein in FTD have led

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb26dfd9a58dfe8e21e3050836c3fee
https://pure.eur.nl/en/publications/b949ea39-975c-4698-abed-1bf8900fb450