DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer

Autor: Maria Zhivagui, Areebah Hoda, Noelia Valenzuela, Yi-Yu Yeh, Jason Dai, Yudou He, Shuvro P. Nandi, Burcak Otlu, Bennett Van Houten, Ludmil B. Alexandrov

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Nail polish dryers commonly emit ultraviolet A (UVA) light, but the effects of this irradiation on mammalian cells remain unclear. Here, the authors examine the effects of UVA irradiation by a nail polish dryer on the genomes of mammalian cell lines,

Externí odkaz: https://doaj.org/article/2c6c07a729a443be94d04a7debf38b91

The genomic and epigenomic evolutionary history of papillary renal cell carcinomas

Autor: Bin Zhu, Maria Luana Poeta, Manuela Costantini, Tongwu Zhang, Jianxin Shi, Steno Sentinelli, Wei Zhao, Vincenzo Pompeo, Maurizio Cardelli, Boian S. Alexandrov, Burcak Otlu, Xing Hua, Kristine Jones, Seth Brodie, Malgorzata Ewa Dabrowska, Jorge R. Toro, Meredith Yeager, Mingyi Wang, Belynda Hicks, Ludmil B. Alexandrov, Kevin M. Brown, David C. Wedge, Stephen Chanock, Vito Michele Fazio, Michele Gallucci, Maria Teresa Landi

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Many tumours are heterogenous, which calls into question whether multiple biopsies are required to accurately assess the cancer. Here, the authors show that papillary renal cell carcinoma is clonal in nature, suggesting that in this cancer one biopsy

Externí odkaz: https://doaj.org/article/ffda5b58926c4a49be8ed66041ae4d4b

Abstract LB059: DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer

Autor: Maria Zhivagui, Areebah Hoda, Noelia Valenzuela, Yi-yu Yeh, Jason Dai, Yudou He, Shuvro P. Nandi, Burcak Otlu, Bennett Van Houten, Ludmil Alexandrov

Publikováno v: Cancer Research. 83:LB059-LB059

Ultraviolet A (UVA) rays are long wavelengths that can penetrate the deeper layer of the skin and are responsible for the immediate tanning effect. A multitude of natural and artificial sources of UV exposure exist, including UV-emitting lamps that a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6dc2afea48e4e7687c01dea830f2db86
https://doi.org/10.1158/1538-7445.am2023-lb059

DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer

Autor: Maria Zhivagui, Areebah Hoda, Noelia Valenzuela, Yi-Yu Yeh, Jason Dai, Yudou He, Shuvro P. Nandi, Burcak Otlu, Bennett Van Houten, Ludmil B. Alexandrov

Publikováno v: Nature communications, vol 14, iss 1

Ultraviolet A light (UVA) is commonly emitted by nail polish dryers with recent reports suggesting that long-term use of UV-nail polish dryers may increase the risk for developing skin cancer. However, no experimental evaluation has been conducted to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24756ed0dc4d7fe9b560d2fdf94a499f
https://doi.org/10.1101/2021.02.03.429605

Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

Autor: David C. Wedge, Michael R. Stratton, Kevin J. Dawson, Sebastian Grossmann, Peter J. Campbell, Jonathan S. Brammeld, Ilias Georgakopoulos-Soares, Young Seok Ju, Sarah O’Meara, Keiran Raine, Calli Latimer, Francesco Iorio, Bee Ling Ng, Burcak Otlu, Kathryn Beal, Jorge Zamora, Adam Butler, Shriram G. Bhosle, Bernardo Rodriguez-Martin, Jennifer Graham, Jon W. Teague, Mark Maddison, Elizabeth Anderson, Nikita Patel, Ludmil B. Alexandrov, Ultan McDermott, Mathew J. Garnett, David Jones, Ching Chiek Koh, Andrew Menzies, Stacey Price, Laura O’Neill, Serena Nik-Zainal, Mia Petljak, Jose M. C. Tubio

Publikováno v: Cell
Petljak, M, Alexandrov, L B, Brammeld, J S, Price, S, Wedge, D C, Grossmann, S, Dawson, K J, Ju, Y S, Iorio, F, Tubio, J M C, Koh, C C, Georgakopoulos-Soares, I, Rodríguez-Martín, B, Otlu, B, O'Meara, S, Butler, A P, Menzies, A, Bhosle, S G, Raine, K, Jones, D R, Teague, J W, Beal, K, Latimer, C, O'Neill, L, Zamora, J, Anderson, E, Patel, N, Maddison, M, Ng, B L, Graham, J, Garnett, M J, McDermott, U, Nik-Zainal, S, Campbell, P J & Stratton, M R 2019, ' Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis ', Cell . https://doi.org/10.1016/j.cell.2019.02.012
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname

Summary Multiple signatures of somatic mutations have been identified in cancer genomes. Exome sequences of 1,001 human cancer cell lines and 577 xenografts revealed most common mutational signatures, indicating past activity of the underlying proces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef46c3ac8f2812db476d77816fba4765
https://www.repository.cam.ac.uk/handle/1810/291718