Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson's disease and Neurodegeneration with Brain Iron Accumulation disorders

Autor: Wise, Rachel M., Wagener, Annika, Fietzek, Urban M., Klopstock, Thomas, Mosharov, Eugene V., Zucca, Fabio A., Sulzer, David, Zecca, Luigi, Burbulla, Lena F.

Publikováno v: In Neurobiology of Disease December 2022 175

Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers

Autor: Sugier, Pierre-Emmanuel, Lucotte, Elise A., Domenighetti, Cloé, Law, Matthew H., Iles, Mark M., Brown, Kevin, Amos, Christopher, McKay, James D., Hung, Rayjean J., Karimi, Mojgan, Bacq-Daian, Delphine, Boland-Augé, Anne, Olaso, Robert, Deleuze, Jean-François, Lesueur, Fabienne, Ostroumova, Evgenia, Kesminiene, Ausrele, de Vathaire, Florent, Guénel, Pascal, consortium, The Epithyr, Sreelatha, Ashwin Ashok Kumar, Schulte, Claudia, Grover, Sandeep, May, Patrick, Bobbili, Dheeraj Reddy, Radivojkov-Blagojevic, Milena, Lichtner, Peter, Singleton, Andrew B., Hernandez, Dena G., Edsall, Connor, Mellick, George D., Zimprich, Alexander, Pirker, Walter, Rogaeva, Ekaterina, Lang, Anthony E., Koks, Sulev, Taba, Pille, Lesage, Suzanne, Brice, Alexis, Corvol, Jean-Christophe, Chartier-Harlin, Marie-Christine, Mutez, Eugénie, Brockmann, Kathrin, Deutschländer, Angela B., Hadjigeorgiou, Georges M., Dardiotis, Efthimios, Stefanis, Leonidas, Simitsi, Athina Maria, Valente, Enza Maria, Petrucci, Simona, Straniero, Letizia, Zecchinelli, Anna, Pezzoli, Gianni, Brighina, Laura, Ferrarese, Carlo, Annesi, Grazia, Quattrone, Andrea, Gagliardi, Monica, Matsuo, Hirotaka, Nakayama, Akiyoshi, Hattori, Nobutaka, Nishioka, Kenya, Chung, Sun Ju, Kim, Yun Joong, Kolber, Pierre, van de Warrenburg, Bart P. C., Bloem, Bastiaan R., Aasly, Jan, Toft, Mathias, Pihlstrøm, Lasse, Guedes, Leonor Correia, Ferreira, Joaquim J., Bardien, Soraya, Carr, Jonathan, Tolosa, Eduardo, Ezquerra, Mario, Pastor, Pau, Diez-Fairen, Monica, Wirdefeldt, Karin, Pedersen, Nancy, Ran, Caroline, Belin, Andrea C., Puschmann, Andreas, Rödström, Emil Ygland, Clarke, Carl E., Morrison, Karen E., Tan, Manuela, Krainc, Dimitri, Burbulla, Lena F., Farrer, Matt J., Krüger, Rejko, Gasser, Thomas, Sharma, Manu, Landoulsi, Zied, consortium, Courage-PD, Truong, Thérèse, Elbaz, Ales

Publikováno v: Movement Disorders, 38, 4, pp. 604-615
the EPITHYR consortium, the Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) consortium, Sugier, PE, Lucotte, E A, Domenighetti, C, Law, M H, Iles, M M, Brown, K, Amos, C, McKay, J D, Hung, R J, Karimi, M, Bacq-Daian, D, Boland-Augé, A, Olaso, R, Deleuze, J, Lesueur, F, Ostroumova, E, Kesminiene, A, de Vathaire, F, Guénel, P, Sreelatha, A A K, Schulte, C, Grover, S, May, P, Bobbili, D R, Radivojkov-Blagojevic, M, Lichtner, P, Singleton, A B, Hernandez, D G, Edsall, C, Mellick, G D, Zimprich, A, Pirker, W, Rogaeva, E, Lang, A E, Koks, S, Taba, P, Lesage, S, Brice, A, Corvol, JC, Chartier-Harlin, MC, Mutez, E, Brockmann, K, Deutschländer, A B, Hadjigeorgiou, G M, Dardiotis, E, Stefanis, L, Simitsi, A M, Valente, E M, Petrucci, S & Morrison, K E 2023, ' Investigation of shared genetic risk factors between Parkinson's disease and cancers ', Movement Disorders . https://doi.org/10.1002/mds.29337
Movement disorders 38(4), 604-615 (2023). doi:10.1002/mds.29337

BackgroundEpidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties.ObjectiveWe used results from genome-wide association stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01807fe357f43b1000ca5296c25c1337
https://doi.org/10.1002/mds.29337

Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons.

Autor: Earley, Aaron M.¹ (AUTHOR), Burbulla, Lena F.^1,2,3,4 (AUTHOR), Krainc, Dimitri¹ (AUTHOR), Awatramani, Rajeshwar¹ (AUTHOR) r-awatramani@northwestern.edu

Publikováno v: Scientific Reports. 11/15/2021, Vol. 11 Issue 1, p1-13. 13p.

Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease: Evidence From the COURAGE-PD Consortium

Autor: Grover, Sandeep, Kumar Sreelatha, Ashwin Ashok, Landoulsi, Zied, May, Patrick, Bobbili, Dheeraj, Edsall, Connor, Bartusch, Felix, Hanussek, Maximilian, Krüger, Jens, Hernandez, Dena G, Blauwendraat, Cornelis, Mellick, George D, Pihlstrom, Lasse, Zimprich, Alexander, Pirker, Walter, Tan, Manuela, Rogaeva, Ekaterina, Lang, Anthony, Koks, Sulev, Taba, Pille, Lesage, Suzanne, Brice, Alexis, Corvol, Jean-Christophe, Domenighetti, Cloé, Chartier-Harlin, Marie-Christine, Mutez, Eugenie, Brockmann, Kathrin, Deutschländer, Angela B, Hadjigeorgiou, Georges M, Dardiotis, Efthimos, Stefanis, Leonidas, Simitsi, Athina Maria, Valente, Enza Maria, Petrucci, Simona, Schulte, Claudia, Straniero, Letizia, Zecchinelli, Anna, Pezzoli, Gianni, Brighina, Laura, Ferrarese, Carlo, Annesi, Grazia, Quattrone, Andrea, Gagliardi, Monica, Burbulla, Lena F, Matsuo, Hirotaka, Sugier, Pierre-Emmanuel, Kawamura, Yusuke, Hattori, Nobutaka, Nishioka, Kenya, Chung, Sun Ju, Kim, Yun Joong, Pavelka, Lukas, van de Warrenburg, Bart P C, Bloem, Bastiaan R, Singleton, Andrew B, Aasly, Jan, Radivojkov-Blagojevic, Milena, Toft, Mathias, Guedes, Leonor Correia, Ferreira, Joaquim J, Bardien, Soraya, Carr, Jonathan, Tolosa, Eduardo, Ezquerra, Mario, Pastor, Pau, Diez-Fairen, Monica, Wirdefeldt, Karin, Lichtner, Peter, Pedersen, Nancy L, Ran, Caroline, Belin, Andrea C, Puschmann, Andreas, Hellberg, Clara, Clarke, Carl E, Morrison, Karen E, Krainc, Dimitri, Farrer, Matt J, Kruger, Rejko, Mohamed, Océane, Elbaz, Alexis, Gasser, Thomas, Sharma, Manu, Genetics, and the Comprehensive Unbiased Risk Factor Assessment for, Disease, Environment in Parkinson's, Portugal, Berta

Publikováno v: Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (COURAGE-PD) consortium 2022, ' Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease: Evidence From the COURAGE-PD Consortium ', Neurology, vol. 99, no. 7, pp. e698-e710 . https://doi.org/10.1212/WNL.0000000000200699
Neurology 99(7), e698-e710 (2022). doi:10.1212/WNL.0000000000200699
Neurology, 99, 7, pp. e698-e710
Neurology
Neurology, 2022, 99 (7), pp.E698-E710. ⟨10.1212/WNL.0000000000200699⟩
Neurology, 99, e698-e710

Background and ObjectivesConsiderable heterogeneity exists in the literature concerning genetic determinants of the age at onset (AAO) of Parkinson disease (PD), which could be attributed to a lack of well-powered replication cohorts. The previous la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9ca595b3b59c1cdb616223dbbc2260
https://pure.qub.ac.uk/en/publications/745af571-7380-437f-911a-29b61a44043b

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

Autor: Reinhardt, Peter, Schmid, Benjamin, Burbulla, Lena F., Schöndorf, David C., Wagner, Lydia, Glatza, Michael, Höing, Susanne, Hargus, Gunnar, Heck, Susanna A., Dhingra, Ashutosh, Wu, Guangming, Müller, Stephan, Brockmann, Kathrin, Kluba, Torsten, Maisel, Martina, Krüger, Rejko, Berg, Daniela, Tsytsyura, Yaroslav, Thiel, Cora S., Psathaki, Olympia-Ekaterini, Klingauf, Jürgen, Kuhlmann, Tanja, Klewin, Marlene, Müller, Heiko, Gasser, Thomas, Schöler, Hans R., Sterneckert, Jared

Publikováno v: In Cell Stem Cell 7 March 2013 12(3):354-367