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Akademický článek

Synthesis biological evaluation and molecular docking of isatin hybrids as anti-cancer and anti-microbial agents

Autor: Mohammad Altamimi, Saeed Ali Syed, Burak Tuzun, Mohammad Rashid Alhazani, Osamah Alnemer, Ahmed Bari

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)

AbstractIsatin, known as 1H-indole-2,3-dione, was originally recognised as a synthetic molecule until its discovery in the fruits of the cannonball tree, Couroupita guianensis. It is naturally occurring in plants of the genus Isatis and serves as a m

Externí odkaz: https://doaj.org/article/9993e68d1666468fac3e6c686a03c2b3

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Akademický článek

8-Aminoquinoline derived two Schiff base platforms: Synthesis, characterization, DFT insights, corrosion inhibitor, molecular docking, and pH-dependent antibacterial study

Autor: Dhrubajyoti Majumdar, Ankita Chatterjee, Mehran Feizi-Dehnayebi, Neelakanta Sarvashiva Kiran, Burak Tuzun, Dipankar Mishra

Publikováno v: Heliyon, Vol 10, Iss 15, Pp e35591- (2024)

The current research divulges the synthesis of two new Schiff base (SB) (LNAPH/LO-VAN) derived from 8-aminoquinoline (8-AMQ) in the presence of 2-hydroxy naphthaldehyde (NAPH) and ortho-vanillin (O-VAN) in CH3OH solvent. They are structurally charact

Externí odkaz: https://doaj.org/article/e87b74752458480281de741c96d7ca61

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Akademický článek

In Silico Development of Novel Benzofuran-1,3,4-Oxadiazoles as Lead Inhibitors of M. tuberculosis Polyketide Synthase 13

Autor: Ali Irfan, Shah Faisal, Ameer Fawad Zahoor, Razia Noreen, Sami A. Al-Hussain, Burak Tuzun, Rakshanda Javaid, Ahmed A. Elhenawy, Magdi E. A. Zaki, Sajjad Ahmad, Magda H. Abdellattif

Publikováno v: Pharmaceuticals, Vol 16, Iss 6, p 829 (2023)

Benzofuran and 1,3,4-oxadiazole are privileged and versatile heterocyclic pharmacophores which display a broad spectrum of biological and pharmacological therapeutic potential against a wide variety of diseases. This article reports in silico CADD (c

Externí odkaz: https://doaj.org/article/a7daf53a686440acbcc642c4ef7275aa

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