Zobrazeno 1 - 10
of 369
pro vyhledávání: '"Burak Erman"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1000-1011 (2020)
K-Ras is the most frequently mutated protein in human cancers. However, until very recently, its oncogenic mutants were viewed as undruggable. To develop inhibitors that directly target oncogenic K-Ras mutants, we need to understand both their mutant
Externí odkaz:
https://doaj.org/article/66dd03eefda54d57bfbe7b6d583d818a
Autor:
Berna Somuncu, Aysegul Ekmekcioglu, Fatma Merve Antmen, Tugce Ertuzun, Emre Deniz, Nazli Keskin, Joon Park, Ilgu Ece Yazici, Busra Simsek, Batu Erman, Whitney Yin, Burak Erman, Meltem Muftuoglu
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Synthetic lethality in DNA repair pathways is an important strategy for the selective treatment of cancer cells without harming healthy cells and developing cancer-specific drugs. The synthetic lethal interaction between the mismatch repair (MMR) pro
Externí odkaz:
https://doaj.org/article/e549a32e79fc4e04a6ae3d3fe74754da
Autor:
Aysima Hacisuleyman, Burak Erman
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 1, p e1005319 (2017)
It has recently been proposed by Gunasakaran et al. that allostery may be an intrinsic property of all proteins. Here, we develop a computational method that can determine and quantify allosteric activity in any given protein. Based on Schreiber's tr
Externí odkaz:
https://doaj.org/article/4f9a266b9b204b4580a4ce8df2f949b3
Autor:
Belinda Nazan Walpoth, Burak Erman
Publikováno v:
F1000Research, Vol 4 (2015)
Protein-protein interactions are the key processes responsible for signaling and function in complex networks. Determining the correct binding partners and predicting the ligand binding sites in the absence of experimental data require predictive mod
Externí odkaz:
https://doaj.org/article/2023cfa3a8b649149dbb0f21fa00b342
Autor:
Burak Erman
Publikováno v:
New Journal of Physics, Vol 18, Iss 4, p 041002 (2016)
Biological molecular motors use chemical energy, mostly in the form of ATP hydrolysis, and convert it to mechanical energy. Correlated thermal fluctuations are essential for the function of a molecular machine and it is the hydrolysis of ATP that mod
Externí odkaz:
https://doaj.org/article/7ffe4cb76f4e41d4b9395c744215b9d9
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e14765 (2011)
BackgroundHistone demethylase, JMJD2A, specifically recognizes and binds to methylated lysine residues at histone H3 and H4 tails (especially trimethylated H3K4 (H3K4me3), trimethylated H3K9 (H3K9me3) and di,trimethylated H4K20 (H4K20me2, H4K20me3))
Externí odkaz:
https://doaj.org/article/36111b93b48f4b4e8304e9595dde5765
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24664 (2011)
Histone modifications have great importance in epigenetic regulation. JMJD2A is a histone demethylase which is selective for di- and trimethyl forms of residues Lys9 and Lys36 of Histone 3 tail (H3K9 and H3K36). We present a molecular dynamics simula
Externí odkaz:
https://doaj.org/article/dee6f486f34b4a0fa70c73da106466a3
Autor:
Ceren Tuzmen, Burak Erman
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16474 (2011)
The nonlocal nature of the protein-ligand binding problem is investigated via the Gaussian Network Model with which the residues lying along interaction pathways in a protein and the residues at the binding site are predicted. The predictions of the
Externí odkaz:
https://doaj.org/article/8f4a8cc9c50f44979c857d403a21d4a3
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10926 (2010)
BackgroundDrug design against proteins to cure various diseases has been studied for several years. Numerous design techniques were discovered for small organic molecules for specific protein targets. The specificity, toxicity and selectivity of smal
Externí odkaz:
https://doaj.org/article/fd2c529eea6c4e20b0c42fc1021c6d42
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 7, p e1000845 (2010)
A statistical thermodynamics approach is proposed to determine structurally and functionally important residues in native proteins that are involved in energy exchange with a ligand and other residues along an interaction pathway. The structure-funct
Externí odkaz:
https://doaj.org/article/94898924c14f4b2cbac31424c5afe9c5