Liver stromal cells restrict macrophage maturation and stromal IL-6 limits the differentiation of cirrhosis-linked macrophages.

Autor: Buonomo EL; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA., Mei S; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Guinn SR; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA; Current Address: The Bloomberg-Kimmel Institute for Cancer Immunotherapy, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Leo IR; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA; Current Address: Department of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Tomtebodavägen 23A, 171 65 Solna, Sweden., Peluso MJ; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA., Nolan MA; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA., Schildberg FA; Clinic for Orthopedics and Trauma Surgery, University Hospital Bonn, 53127 Bonn, Germany., Zhao L; Department of Pathology, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA., Lian C; Department of Pathology, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA., Xu S; Department of Pathology, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA., Misdraji J; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Kharchenko PV; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Cambridge MA, USA., Sharpe AH; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. Electronic address: arlene_sharpe@hms.harvard.edu.

Publikováno v: Journal of hepatology [J Hepatol] 2022 May; Vol. 76 (5), pp. 1127-1137. Date of Electronic Publication: 2022 Jan 21.

Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection.

Autor: Saleh MM; Department of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, VA 22908, USA., Frisbee AL; Department of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, VA 22908, USA., Leslie JL; Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA., Buonomo EL; Department of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, VA 22908, USA., Cowardin CA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, VA 22908, USA., Ma JZ; Division of Biostatistics, Department of Public Health Sciences, School of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA., Simpson ME; Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA., Scully KW; Department of Public Health Sciences, University of Virginia Health System, Charlottesville, VA 22908, USA., Abhyankar MM; Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA., Petri WA Jr; Department of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, VA 22908, USA; Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA; Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA. Electronic address: wap3g@virginia.edu.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2019 May 08; Vol. 25 (5), pp. 756-765.e5. Date of Electronic Publication: 2019 Apr 16.

Development and Validation of a Prediction Model for Mortality and Adverse Outcomes Among Patients With Peripheral Eosinopenia on Admission for Clostridium difficile Infection.

Autor: Kulaylat AS; Department of Surgery, Pennsylvania State University, College of Medicine, Hershey., Buonomo EL; Department of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville., Scully KW; Department of Public Health Sciences, University of Virginia, Charlottesville., Hollenbeak CS; Department of Surgery, Pennsylvania State University, College of Medicine, Hershey.; Department of Public Health Sciences, Pennsylvania State University, College of Medicine, Hershey., Cook H; Department of Statistics, University of Virginia, Charlottesville., Petri WA Jr; Department of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville.; Department of Medicine, University of Virginia Health System, Charlottesville.; Department of Pathology, University of Virginia Health System, Charlottesville., Stewart DB Sr; Department of Surgery, University of Arizona, Tucson.

Publikováno v: JAMA surgery [JAMA Surg] 2018 Dec 01; Vol. 153 (12), pp. 1127-1133.

The microbiota and immune response during Clostridium difficile infection.

Autor: Buonomo EL; Department of Microbiology, Immunology and Cancer, University of Virginia Charlottesville, VA, 22908, USA. Electronic address: elb3ea@virginia.edu., Petri WA Jr; Department of Microbiology, Immunology and Cancer, University of Virginia Charlottesville, VA, 22908, USA; Department of Medicine, University of Virginia, USA; Department of Pathology, University of Virginia, USA. Electronic address: wap3g@virginia.edu.

Publikováno v: Anaerobe [Anaerobe] 2016 Oct; Vol. 41, pp. 79-84. Date of Electronic Publication: 2016 May 20.

The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia.

Autor: Cowardin CA; Departments of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia 22908 USA., Buonomo EL; Departments of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia 22908 USA., Saleh MM; Departments of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia 22908 USA., Wilson MG; Departments of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia 22908 USA., Burgess SL; Departments of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia 22908 USA., Kuehne SA; Clostridia Research Group, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK., Schwan C; Institute of Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs-University of Freiburg, Freiburg, Germany., Eichhoff AM; Institute of Immunology, University Medical Center Hamburg-Eppendorf, D20246 Hamburg, Germany., Koch-Nolte F; Institute of Immunology, University Medical Center Hamburg-Eppendorf, D20246 Hamburg, Germany., Lyras D; Department of Microbiology, Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Monash University, Victoria 3800, Australia., Aktories K; Institute of Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs-University of Freiburg, Freiburg, Germany., Minton NP; Clostridia Research Group, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK., Petri WA Jr; Departments of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia 22908 USA.; Departments of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 USA.; Departments of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908, USA.

Publikováno v: Nature microbiology [Nat Microbiol] 2016 Jul 11; Vol. 1 (8), pp. 16108. Date of Electronic Publication: 2016 Jul 11.