X chromosome inactivation skewing is common in advanced carotid atherosclerotic lesions in females and predicts secondary peripheral artery events.

Autor: Buono MF; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Benavente ED; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Daniels M; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Mol BM; Department of Vascular Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Mekke JM; Department of Vascular Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., de Borst GJ; Department of Vascular Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., de Kleijn DPV; Department of Vascular Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van der Laan SW; Central Diagnostics Laboratory, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Pasterkamp G; Central Diagnostics Laboratory, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Onland-Moret C; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Mokry M; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Central Diagnostics Laboratory, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., den Ruijter HM; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. H.M.denRuijter-2@umcutrecht.nl.

Publikováno v: Biology of sex differences [Biol Sex Differ] 2023 Jul 05; Vol. 14 (1), pp. 43. Date of Electronic Publication: 2023 Jul 05.

Human Cardiac Organoids for Disease Modeling.

Autor: Nugraha B; Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland., Buono MF; Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland., von Boehmer L; Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland., Hoerstrup SP; Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.; Wyss Translational Center Zurich, Zurich, Switzerland., Emmert MY; Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.; Wyss Translational Center Zurich, Zurich, Switzerland.; Department of Cardiovascular Surgery, Charité Universitätsmedizin Berlin, Berlin, Germany.; Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2019 Jan; Vol. 105 (1), pp. 79-85. Date of Electronic Publication: 2018 Dec 21.

Recellularized Native Kidney Scaffolds as a Novel Tool in Nephrotoxicity Screening.

Autor: Fedecostante M; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.)., Westphal KGC; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.)., Buono MF; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.)., Sanchez Romero N; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.)., Wilmer MJ; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.)., Kerkering J; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.)., Baptista PM; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.)., Hoenderop JG; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.)., Masereeuw R; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.) r.masereeuw@uu.nl.

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2018 Sep; Vol. 46 (9), pp. 1338-1350. Date of Electronic Publication: 2018 Jul 06.