Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Bunnai, Saito"'
Autor:
Kensuke Sakuma, Noriko Tsubooka-Yamazoe, Kiyohiro Hashimoto, Nozomu Sakai, Shinya Asano, Saori Watanabe-Matsumoto, Takeshi Watanabe, Bunnai Saito, Hirokazu Matsumoto, Hikaru Ueno, Ryo Ito, Taro Toyoda
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Background Transplantation of differentiated cells from human-induced pluripotent stem cells (hiPSCs) holds great promise for clinical treatments. Eliminating the risk factor of malignant cell transformation is essential for ensuring the saf
Externí odkaz:
https://doaj.org/article/a21dd5df379540a8874afc1118b6fef0
Autor:
Masanori Okaniwa, Daisuke Morishita, Michael G. Klein, Yuta Tanaka, Bunnai Saito, Shigemitsu Matsumoto, Shinichi Imamura, Hiromichi Kimura, Geza Ambrus-Aikelin, Noriko Uchiyama, Osamu Kurasawa, Akihiro Yokota
Publikováno v:
ACS Medicinal Chemistry Letters
Deoxyhypusine synthase (DHPS) is the primary enzyme responsible for the hypusine modification and, thereby, activation of the eukaryotic translation initiation factor 5A (eIF5A), which is key in regulating the protein translation processes associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bd704a89e8cc67818ed1d96f73e5cb
https://doi.org/10.1021/acsmedchemlett.0c00331
https://doi.org/10.1021/acsmedchemlett.0c00331
Autor:
Masanori Okaniwa, Geza Ambrus-Aikelin, Shigemitsu Matsumoto, Yuta Tanaka, Akihiro Yokota, Koji Ono, Kazumasa Ogawa, Daisuke Morishita, Satoshi Kitazawa, Osamu Kurasawa, Michael G. Klein, Shinichi Imamura, Hiromichi Kimura, Noriko Uchiyama, Bunnai Saito
Publikováno v:
Journal of Medicinal Chemistry. 63:3215-3226
Deoxyhypusine synthase (DHPS) utilizes spermidine and NAD as cofactors to incorporate a hypusine modification into the eukaryotic translation initiation factor 5A (eIF5A). Hypusine is essential for eIF5A activation, which, in turn, plays a key role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e648ed2ccf973369eef613b4ca77329
https://doi.org/10.1021/acs.jmedchem.9b01979
https://doi.org/10.1021/acs.jmedchem.9b01979
Autor:
Hiroki Kondo, Masayuki Komatsuda, Ayane Suto, Junichiro Yamaguchi, Bunnai Saito, Hiroyuki Takada, Kenta Kato
Publikováno v:
Chemical science. 13(3)
We have discovered a ring-opening fluorination of bicyclic azaarenes. Upon treatment of bicyclic azaarenes such as pyrazolopyridines with electrophilic fluorinating agents, fluorination of the aromatic ring is followed by a ring-opening reaction. Alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7427d14419980fa73d959d58ef96c9b9
https://pubmed.ncbi.nlm.nih.gov/35173930
https://pubmed.ncbi.nlm.nih.gov/35173930
Autor:
Akiko Oki, Katsunori Sasa, Hiroyuki Takada, Bunnai Saito, Kazumasa Miyamoto, Tomoko Nagino, Hidetoshi Sakurai, Ryuichi Tozawa, Tatsuo Oikawa, Makoto Miyamoto, Yuko Kokubu, Michiko Tawada, Tomoya Sameshima, Akira Kaieda
Publikováno v:
Journal of Medicinal Chemistry. 62:9175-9187
Dysferlinopathies, which are muscular diseases caused by mutations in the dysferlin gene, remain serious medical problems due to the lack of therapeutic agents. Herein, we report the design, synthesis, and structure-activity relationships of a 2,6-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9111b391e088e8dd74adcaa24e72217
https://doi.org/10.1021/acs.jmedchem.9b01100
https://doi.org/10.1021/acs.jmedchem.9b01100
Autor:
Akio Mizutani, Yoshinori Satomi, Masahiro Yaguchi, Yasuhiro Hirata, Kazunobu Aoyama, Atsushi Kiba, Bunnai Saito, Megumi Hirayama, Takuto Kojima, Shinichi Imamura, Tzu-Tshin Wong, Yasufumi Miyamoto, Kazuko Yonemori, Yuta Tanaka, Ryosuke Arai, Osamu Sano, Osamu Kurasawa, Yasutomi Asano, Naoki Iwamura, Yuto Hiura, Shuji Kitamura, Ryutaro Adachi, Sachio Shibata, Yoji Sagiya
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:2452-2465
We pursued serine palmitoyltransferase (SPT) inhibitors as novel cancer therapeutic agents based on a correlation between SPT inhibition and growth suppression of cancer cells. High-throughput screening and medicinal chemistry efforts led to the iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7fa9f9903cad0df529e2e8edb6f04a
https://doi.org/10.1016/j.bmc.2018.04.008
https://doi.org/10.1016/j.bmc.2018.04.008
Autor:
Hiroyuki, Takada, Akira, Kaieda, Michiko, Tawada, Tomoko, Nagino, Katsunori, Sasa, Tatsuo, Oikawa, Akiko, Oki, Tomoya, Sameshima, Kazumasa, Miyamoto, Makoto, Miyamoto, Yuko, Kokubu, Ryuichi, Tozawa, Hidetoshi, Sakurai, Bunnai, Saito
Publikováno v:
Journal of medicinal chemistry. 62(20)
Dysferlinopathies, which are muscular diseases caused by mutations in the dysferlin gene, remain serious medical problems due to the lack of therapeutic agents. Herein, we report the design, synthesis, and structure-activity relationships of a 2,6-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd17d6870974e86fdd2fb0361e89ead6
https://pubmed.ncbi.nlm.nih.gov/31550153
https://pubmed.ncbi.nlm.nih.gov/31550153
Autor:
Kentaro Hashimoto, Shoko Takeuchi, Yukihiro Ikeda, Tomoyasu Ishikawa, Hiroyuki Sumi, Takashi Kojima, Bunnai Saito
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 63:858-865
Different crystal packing of hydrates from anhydrate crystals leads to different physical properties, such as solubility and stability. Investigation of the potential of varied hydrate formation, and understanding the stability in an anhydrous/hydrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36337867b828fb64398b5c988ea8deaf
https://doi.org/10.1248/cpb.c15-00262
https://doi.org/10.1248/cpb.c15-00262
Autor:
Yuta Tanaka, Osamu Kurasawa, Akihiro Yokota, Klein, Michael G., Bunnai Saito, Shigemitsu Matsumoto, Masanori Okaniwa, Ambrus-Aikelin, Geza, Uchiyama, Noriko, Daisuke Morishita, Hiromichi Kimura, Shinichi Imamura
Publikováno v:
ACS Medicinal Chemistry Letters; 8/13/2020, Vol. 11 Issue 8, p1645-1652, 8p
Autor:
Tomoyasu Ishikawa, Masato Yabuki, Sei Yoshida, Nao Morishita, Teruki Hamada, Kentaro Hashimoto, Clifford D. Mol, Douglas R. Dougan, Kazunobu Aoyama, Zenyu Shiokawa, Hiroyuki Sumi, Moriteru Asano, Mie Yoshimatsu, Bunnai Saito
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:5725-5737
We recently reported the discovery of octahydropyrrolo[1,2-a]pyrazine A as a lead compound for an inhibitor of apoptosis proteins (IAP) antagonist. To develop IAP antagonists with favorable PK profiles, we designed novel tri-cyclic compounds, octahyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aaf7eac41ce20577a038d7a5215f402
https://doi.org/10.1016/j.bmc.2013.07.020
https://doi.org/10.1016/j.bmc.2013.07.020