Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Bunkichi Tsunekawa"'
Publikováno v:
Endocrinology. 140:3909-3918
Previously we have demonstrated that 20-kDa human GH (20K-hGH) is a full agonist for hGH receptor (hGHR) even though its complex formation with hGHR and hGH-binding protein differs from that of 22-kDa human GH (22K-hGH). In this study, we focused on
Autor:
Bunkichi Tsunekawa, Hiroshi Uchida, Shinichi Banba, Masaru Honjo, Mitsufumi Wada, Eishi Tanaka, Naokazu Naito, Miwa Ikeda, Yoshihide Hashimoto
Publikováno v:
Molecular Endocrinology. 12:146-156
In spite of recent advance in understanding of the stoichiometry of 22-kDa human GH (22K-hGH) with cell surface hGH receptor (hGHR) and hGH-binding protein (hGH-BP) circulating in human plasma, that of 20-kDa hGH (20K-hGH) is poorly understood. To cl
Autor:
Bunkichi Tsunekawa, Miwa Ikeda, Shinichi Banba, Masaru Honjo, Hironori Kamachi, Eishi Tanaka, Mitsufumi Wada
Publikováno v:
The Journal of biological chemistry. 275(21)
Despite the lower site 1 affinity of the 20-kDa human growh hormone (20K-hGH) for the hGH receptor (hGHR), 20K-hGH has the same hGHR-mediated activity as 22-kDa human GH (22K-hGH) at low hGH concentration and even higher activity at high hGH concentr