Molecular insights into the surface-catalyzed secondary nucleation of amyloid-β₄₀ (Aβ₄₀) by the peptide fragment Aβ₁₆-₂₂

Autor: Bunce, SJ, Wang, Y, Stewart, KL, Ashcroft, AE, Radford, SE, Hall, CK, Wilson, AJ

Understanding the structural mechanism by which proteins and peptides aggregate is crucial given the role of fibrillar aggregates in debilitating amyloid diseases and bioinspired materials. Yet, this is a major challenge given assembly involves multi

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https://eprints.whiterose.ac.uk/145685/5/eaav8216.full.pdf

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Molecular insights into the surface-catalyzed secondary nucleation of amyloid-β 40 (Aβ 40 ) by the peptide fragment Aβ 16-22 .

Autor: Bunce SJ; School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK., Wang Y; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905, USA., Stewart KL; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., Ashcroft AE; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., Radford SE; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., Hall CK; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905, USA., Wilson AJ; School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

Publikováno v: Science advances [Sci Adv] 2019 Jun 21; Vol. 5 (6), pp. eaav8216. Date of Electronic Publication: 2019 Jun 21 (Print Publication: 2019).