Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Bumjoon Cha"'
Autor:
Anthony Tantuccio, Matt Metzger, Seo-Young Park, Huolong Liu, Zhuangrong Huang, Matthew Flamm, Shaun C. Galbraith, Bumjoon Cha, Seongkyu Yoon
Publikováno v:
Pharmaceutical Development and Technology. 25:1204-1215
Continuous manufacturing of oral-dosage drug products is increasing the need for rigorous process understanding both from a process design and control perspective. The purpose of this study is to develop a methodology that analyzes the effects of ups
Autor:
Bumjoon Cha, Huolong Liu, F. Zhang-Plasket, Zhuangrong Huang, Shaun C. Galbraith, Robert F. Meyer, Matthew Flamm, Seongkyu Yoon, S. Hurley, Seo-Young Park
Publikováno v:
Powder Technology. 354:199-210
A flowsheet model for a continuous direct compression tableting process is developed and applied to process data generated at production scale. The model contains powder feeding, blending and tablet compaction unit operations. The dataset was provide
Autor:
Shaun C. Galbraith, Zhuangrong Huang, Sau L. Lee, Huolong Liu, Bumjoon Cha, Hae Woo Lee, Seo-Young Park, Seongkyu Yoon, Thomas F. O’Connor
Publikováno v:
Powder Technology. 330:461-470
Roller compaction is a dry granulation process for manufacturing solid drug formulations. A flowing powder is continuously fed into the counter-rotating rolls and compacted into dense ribbons. These ribbons are subsequently broken into granules by mi
Publikováno v:
Preparative Biochemistry & Biotechnology. 48:242-256
A modified shrinking core model (MSCM) has been used to describe the mechanism for the degradation of Protein A resin particles taking place under continuous chromatographic operation. The model is based on the hypothetical shrinkage of the boundary
Autor:
Robert F. Meyer, Sau L. Lee, Seo-Young Park, Matthew Flamm, Shaun C. Galbraith, Bumjoon Cha, Seongkyu Yoon, Zhuangrong Huang, Huolong Liu, Thomas F. O’Connor
Publikováno v:
Pharmaceutical Development and Technology. 24:105-117
In this study, a novel three-compartmental population balance model (PBM) for a continuous twin screw wet granulation process is developed, combining the techniques of PBM and regression process modeling. The developed model links screw configuration
Autor:
Shaun C. Galbraith, Zhuangrong Huang, Huolong Liu, Thomas F. O’Connor, Seongkyu Yoon, Sau L. Lee, Seo-Young Park, Bumjoon Cha
Publikováno v:
AAPS PharmSciTech. 20(5)
A tablet film coating and drying process was assessed by an experimentally validated thermodynamic balance model. Mass conservation equations were derived for the process air and the aqueous coating solution. Thermodynamic behavior of the solution wa
Autor:
Seungmin Han, Bongsoo Kim, Seo Ryung Bae, Moo Kwang Shin, Seungjoo Haam, Il Moon, Yong Min Huh, Bumjoon Cha, Hye Yeong Son, Eunji Jang, Unyong Jeong, Hyun Ouk Kim, Byunghoon Kang
Publikováno v:
Analytical Chemistry. 88:1078-1082
A novel method (i.e., continuous magnetic cell separation in a microfluidic channel) is demonstrated to be capable of inducing multifractionation of mixed cell suspensions into multiple outlet fractions. Here, multicomponent cell separation is perfor
Autor:
Seongkyu Yoon, Shaun C. Galbraith, Huolong Liu, Bumjoon Cha, Zhuangrong Huang, Seo-Young Park
Publikováno v:
Pharmaceutical development and technology. 23(10)
Continuous manufacturing techniques are increasingly being adopted in the pharmaceutical industry and powder blending is a key operation for solid-dosage tablets. A modeling methodology involving axial and radial tanks-in-series flowsheet models is d
Continuous manufacturing for the production of pharmaceutical products is emerging as a key technology due to the advantages it has over traditional batch manufacturing methods. Process systems engineering is critical in rolling out this technology w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28513feb7d12f44a6965c8b7548df101
https://doi.org/10.1016/b978-0-444-63963-9.00005-1
https://doi.org/10.1016/b978-0-444-63963-9.00005-1
Publikováno v:
Industrial & Engineering Chemistry Research. 52:7252-7258
Computational particle fluid dynamics (CPFD) simulation was carried out to analyze flow patterns in order to understand the mechanism of deposit formation on the cyclone duct during the residue flu...