Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Bumhee Lim"'
Autor:
Yun-Jeong Kim, Bumhee Lim, Seo Young Kim, Yoon-Ze Shin, Nayoung Yu, Eun-Kyung Shin, Jae-Eon Lee, Yong Hyun Jeon, Dae-Duk Kim, Jeeyeon Lee, Hyuk-Jin Cha
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116758- (2024)
Sorafenib (BAY 43–9006) was developed as a multi-kinase inhibitor to treat advanced renal cell, hepatocellular, and thyroid cancers. The cytotoxic effect of sorafenib on cancer cells results from not only inhibiting the MEK/ERK signaling pathway (t
Externí odkaz:
https://doaj.org/article/f9be2ef7a3bb412988718f210627affe
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1656-1666 (2022)
Despite extensive efforts over 40 years, few effective KRAS inhibitors have been developed to date, mainly due to the undruggable features of KRAS proteins. In addition to the direct approach to KRAS via covalent inhibition, modulation of the prenyl-
Externí odkaz:
https://doaj.org/article/78cbe805ec714df4ae745259fba585aa
Autor:
Quentin Laurent, Rémi Martinent, Bumhee Lim, Anh-Tuan Pham, Takehiro Kato, Javier López-Andarias, Naomi Sakai, Stefan Matile
Publikováno v:
JACS Au, Vol 1, Iss 6, Pp 710-728 (2021)
Externí odkaz:
https://doaj.org/article/934547d5f5734de5886a3df89bb6561a
Autor:
Bumhee Lim, Jeeyeon Lee
Publikováno v:
Molecules, Vol 21, Iss 3, p 339 (2016)
Peptoids, N-substituted glycine oligomers, are versatile peptidomimetics with diverse biomedical applications. However, strategies to the development of novel fluorescent peptoids as chemical sensors have not been extensively explored, yet. Here, we
Externí odkaz:
https://doaj.org/article/5b85286051f84f5a819a06a0ea2c9770
Publikováno v:
Helvetica Chimica Acta.
Autor:
Bumhee Lim, Takehiro Kato, Celine Besnard, Amalia I. Poblador Bahamonde, Naomi Sakai, Stefan Matile
Publikováno v:
JACS Au. 2:1105-1114
Dynamic covalent exchange cascades with cellular thiols are of interest to deliver substrates to the cytosol and to inhibit the entry of viruses. The best transporters and inhibitors known today are cyclic cascade exchangers (CAXs), producing a new e
Autor:
Yunha Kim, Honglan Pei, Seung Yeob Hyun, Ho-Young Lee, Bumhee Lim, Jeeyeon Lee, Dae-Duk Kim, Min Hwan Kim, Byungjin Kim, Byungyeob Baek, Phuong Chi Pham, Ho Jin Lee, Nae Won Kang, Hye-Young Min
Publikováno v:
Theranostics
Rationale: The type I insulin-like growth factor receptor (IGF-1R) signaling pathway plays key roles in the development and progression of numerous types of human cancers, and Src and AXL have been found to confer resistance to anti-IGF-1R therapies.
Autor:
Yangyang Cheng, Stefan Matile, Anh Tuan Pham, Bumhee Lim, Naomi Sakai, Takehiro Kato, Javier López-Andarias, Dimitri Moreau, Lili Zong
Publikováno v:
Chemical Science
Chemical Science, Vol. 12, No 2 (2021) pp. 626-631
Chemical Science, Vol. 12, No 2 (2021) pp. 626-631
Ellman's reagent has caused substantial confusion and concern as a probe for thiol-mediated uptake because it is the only established inhibitor available but works neither efficiently nor reliably. Here we use fluorescent cyclic oligochalcogenides th
Autor:
Takehiro Kato, Bumhee Lim, Yangyang Cheng, Anh-Tuan Pham, John Maynard, Dimitri Moreau, Amalia I. Poblador-Bahamonde, Naomi Sakai, Stefan Matile
Publikováno v:
JACS Au, Vol. 2, No 4 (2022) pp. 839-852
Thiol-mediated uptake is emerging as a powerful method to penetrate cells. Cyclic oligochalcogenides (COCs) have been identified as privileged scaffolds to enable and inhibit thiol-mediated uptake because they can act as dynamic covalent cascade exch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a584be43581266a752b8613f3035e7
https://archive-ouverte.unige.ch/unige:160354
https://archive-ouverte.unige.ch/unige:160354
Autor:
Hyonseok Hwang, Ikyon Kim, Jeeyeon Lee, Ji Hye Lee, Gyuseok Sim, Na Keum Lee, Jaehyun Park, Bumhee Lim, Seol Ryu
Publikováno v:
ChemPhotoChem. 5:58-67