Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Bum-Rak Choi"'
ML-GAP: machine learning-enhanced genomic analysis pipeline using autoencoders and data augmentation
Autor:
Melih Agraz, Dincer Goksuluk, Peng Zhang, Bum-Rak Choi, Richard T. Clements, Gaurav Choudhary, George Em Karniadakis
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
IntroductionThe advent of RNA sequencing (RNA-Seq) has significantly advanced our understanding of the transcriptomic landscape, revealing intricate gene expression patterns across biological states and conditions. However, the complexity and volume
Externí odkaz:
https://doaj.org/article/47840e320b1f4afaaecb8f10ac3db67a
Autor:
Brett C Baggett, Kevin R Murphy, Elif Sengun, Eric Mi, Yueming Cao, Nilufer N Turan, Yichun Lu, Lorraine Schofield, Tae Yun Kim, Anatoli Y Kabakov, Peter Bronk, Zhilin Qu, Patrizia Camelliti, Patrycja Dubielecka, Dmitry Terentyev, Federica del Monte, Bum-Rak Choi, John Sedivy, Gideon Koren
Publikováno v:
eLife, Vol 12 (2023)
Progressive tissue remodeling after myocardial infarction (MI) promotes cardiac arrhythmias. This process is well studied in young animals, but little is known about pro-arrhythmic changes in aged animals. Senescent cells accumulate with age and acce
Externí odkaz:
https://doaj.org/article/d202d60827684d86801b098db8759f70
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Background and significanceThe specialized conduction system (SCS) of the heart was extensively studied to understand the synchronization of atrial and ventricular contractions, the large atrial to His bundle (A-H) delay through the atrioventricular
Externí odkaz:
https://doaj.org/article/e8f4cadf34f046c39f84e1c61ea0ea57
Autor:
Arvin H Soepriatna, Allison Navarrete-Welton, Tae Yun Kim, Mark C Daley, Peter Bronk, Celinda M Kofron, Ulrike Mende, Kareen L K Coulombe, Bum-Rak Choi
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0280406 (2023)
Recent advances in human induced pluripotent stem cell (hiPSC)-derived cardiac microtissues provide a unique opportunity for cardiotoxic assessment of pharmaceutical and environmental compounds. Here, we developed a series of automated data processin
Externí odkaz:
https://doaj.org/article/2f97697e482841788bf25e944eb37c7d
Autor:
Celinda M. Kofron, Tae Yun Kim, Fabiola Munarin, Arvin H. Soepriatna, Rajeev J. Kant, Ulrike Mende, Bum-Rak Choi, Kareen L. K. Coulombe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Cardiotoxicity of pharmaceutical drugs, industrial chemicals, and environmental toxicants can be severe, even life threatening, which necessitates a thorough evaluation of the human response to chemical compounds. Predicting risks for arrhyt
Externí odkaz:
https://doaj.org/article/75b6c068a5ce412c8a3e790024a14557
Autor:
Kiera D. Dwyer, Rajeev J. Kant, Arvin H. Soepriatna, Stephanie M. Roser, Mark C. Daley, Sharif A. Sabe, Cynthia M. Xu, Bum-Rak Choi, Frank W. Sellke, Kareen L. K. Coulombe
Publikováno v:
Bioengineering, Vol 10, Iss 5, p 587 (2023)
Despite the overwhelming use of cellularized therapeutics in cardiac regenerative engineering, approaches to biomanufacture engineered cardiac tissues (ECTs) at clinical scale remain limited. This study aims to evaluate the impact of critical biomanu
Externí odkaz:
https://doaj.org/article/e9e51b43616342d6b1ed0a5a15121a99
Publikováno v:
Stem Cells International, Vol 2020 (2020)
Cardiac tissue engineering using hiPSC-derived cardiomyocytes is a promising avenue for cardiovascular regeneration, pharmaceutical drug development, cardiotoxicity evaluation, and disease modeling. Limitations to these applications still exist due i
Externí odkaz:
https://doaj.org/article/4c8c919826754f6ca3b47b97f874cb60
Autor:
Shanna Hamilton, Radmila Terentyeva, Tae Yun Kim, Peter Bronk, Richard T. Clements, Jin O-Uchi, György Csordás, Bum-Rak Choi, Dmitry Terentyev
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
In a physiological setting, mitochondria increase oxidative phosphorylation during periods of stress to meet increased metabolic demand. This in part is mediated via enhanced mitochondrial Ca2+ uptake, an important regulator of cellular ATP homeostas
Externí odkaz:
https://doaj.org/article/afd9fd2a470d40ac8bbdb50a6b5dfb09
Autor:
Tae Yun Kim, Celinda M Kofron, Michelle E King, Alexander R Markes, Amenawon O Okundaye, Zhilin Qu, Ulrike Mende, Bum-Rak Choi
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196714 (2018)
Multicellular spheroids generated through cellular self-assembly provide cytoarchitectural complexities of native tissue including three-dimensionality, extensive cell-cell contacts, and appropriate cell-extracellular matrix interactions. They are in
Externí odkaz:
https://doaj.org/article/0d5d48ad26464c1ea579e37b41894081
Autor:
Julia H Indik, Vineet Nair, Ruslan Rafikov, Iwan S Nyotowidjojo, Jaskanwal Bisla, Mayank Kansal, Devang S Parikh, Melissa Robinson, Anand Desai, Megha Oberoi, Akash Gupta, Taimur Abbasi, Zain Khalpey, Amit R Patel, Roberto M Lang, Samuel C Dudley, Bum-Rak Choi, Joe G N Garcia, Roberto F Machado, Ankit A Desai
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164526 (2016)
Sudden death is a leading cause of mortality in sickle cell disease, implicating ventricular tachyarrhythmias. Prolonged QTc on an electrocardiogram (ECG), commonly seen with myocardial ischemia, is a known risk for polymorphic ventricular tachycardi
Externí odkaz:
https://doaj.org/article/9f2a02da94f940d194963dbc14c1f793