Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Bum Kyu Lee"'
Autor:
Alessandra Machado Araujo, Joseph D Dekker, Kendra Garrison, Zhe Su, Catherine Rhee, Zicheng Hu, Bum-Kyu Lee, Daniel Osorio, Jiwon Lee, Vishwanath R Iyer, Lauren IR Ehrlich, George Georgiou, Gregory Ippolito, Stephen Yi, Haley O Tucker
Publikováno v:
eLife, Vol 13 (2024)
We identified a novel mouse plasmacytoid dendritic cell (pDC) lineage derived from the common lymphoid progenitors (CLPs) that is dependent on expression of Bcl11a. These CLP-derived pDCs, which we refer to as ‘B-pDCs’, have a unique gene express
Externí odkaz:
https://doaj.org/article/80e19280b37e44668886ed8fca1eecca
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The placenta serves as an essential organ for fetal growth throughout pregnancy. Histone modification is a crucial regulatory mechanism involved in numerous biological processes and development. Nevertheless, there remains a significant gap
Externí odkaz:
https://doaj.org/article/6cbfad91b9094cff96dc130446096052
Autor:
Mijeong Kim, Yu Jin Jang, Muyoung Lee, Qingqing Guo, Albert J. Son, Nikita A. Kakkad, Abigail B. Roland, Bum-Kyu Lee, Jonghwan Kim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract During human pregnancy, extravillous trophoblasts play crucial roles in placental invasion into the maternal decidua and spiral artery remodeling. However, regulatory factors and their action mechanisms modulating human extravillous trophobl
Externí odkaz:
https://doaj.org/article/5894419c30db4a978c419bef5f76b63e
Autor:
Mijeong Kim, Manjot Singh, Bum-Kyu Lee, Moira Hibbs, Kirsty Richardson, Lesley Ellies, Larissa Wintle, Lisa M. Stuart, Jenny Y. Wang, Dominic C. Voon, Pilar Blancafort, Jianlong Wang, Jonghwan Kim, Peter J. Leedman, Andrew J. Woo
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-13 (2022)
Abstract The MYC proto-oncogene (MYC) is one of the most frequently overexpressed genes in breast cancer that drives cancer stem cell-like traits, resulting in aggressive disease progression and poor prognosis. In this study, we identified zinc finge
Externí odkaz:
https://doaj.org/article/3a2eb9d8862b4252af620303b3ec1a97
Autor:
Eui-Hwan Choi, Seobin Yoon, Young Eun Koh, Tae Kyung Hong, Jeong Tae Do, Bum-Kyu Lee, Yoonsoo Hahn, Keun P. Kim
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-31 (2022)
Abstract Background Cohesin is a chromosome-associated SMC–kleisin complex that mediates sister chromatid cohesion, recombination, and most chromosomal processes during mitosis and meiosis. However, it remains unclear whether meiosis-specific cohes
Externí odkaz:
https://doaj.org/article/d76b5b5d8acd4d09ae6d47331e59ec91
Autor:
Machado Araujo, Alessandra, Dekker, Joseph D., Garrison, Kendra, Zhe Su, Rhee, Catherine, Zicheng Hu, Bum-Kyu Lee, Osorio, Daniel, Lee, Jiwon, Iyer, Vishwanath R., Ehrlich, Lauren I. R., Georgiou, George, Ippolito, Gregory, Yi, Stephen, Tucker, Haley O.
Publikováno v:
eLife; 9/13/2024, p1-19, 19p
Autor:
Emily Golden, Rabab Rashwan, Eleanor A. Woodward, Agustin Sgro, Edina Wang, Anabel Sorolla, Charlene Waryah, Wan Jun Tie, Elisabet Cuyàs, Magdalena Ratajska, Iwona Kardaś, Piotr Kozlowski, Elizabeth K. M. Johnstone, Heng B. See, Ciara Duffy, Jeremy Parry, Kim A. Lagerborg, Piotr Czapiewski, Javier A. Menendez, Adam Gorczyński, Bartosz Wasag, Kevin D. G. Pfleger, Christina Curtis, Bum-Kyu Lee, Jonghwan Kim, Joseph Cursons, Nathan J. Pavlos, Wojciech Biernat, Mohit Jain, Andrew J. Woo, Andrew Redfern, Pilar Blancafort
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Adipogenesis associated Mth938 Domain Containing gene (AAMDC) is frequently amplified in the IntClus2 subgroup of ER + breast cancer. Here, the authors show that AAMDC drives tumourigenesis through activating PI3K-AKT-mTOR pathway for metabolic repro
Externí odkaz:
https://doaj.org/article/7a78efc95f94434186efe33c5a90c19a
Autor:
Bum-Kyu Lee, Jonghwan Kim
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The placenta is a temporary but pivotal organ for human pregnancy. It consists of multiple specialized trophoblast cell types originating from the trophectoderm of the blastocyst stage of the embryo. While impaired trophoblast differentiation results
Externí odkaz:
https://doaj.org/article/9a85dc2c689244a1b7c07d0d749aa2b4
Autor:
Bum-Kyu Lee, Yu jin Jang, Mijeong Kim, Lucy LeBlanc, Catherine Rhee, Jiwoon Lee, Samuel Beck, Wenwen Shen, Jonghwan Kim
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Trophectoderm lineage development is essential for implantation, placentation, and healthy pregnancy. Here the authors map super-enhancers (SEs) in trophoblast stem cells and find both TE-specific master regulators and 150 previous uncharacterised tr
Externí odkaz:
https://doaj.org/article/7542d27cd2304f37a4ead0cec651eb99
Publikováno v:
Nucleic Acids Research. 51:3806-3819
The placenta is an essential organ that supports the growth and development of the fetus during pregnancy. However, cell type-specific enhancers and transcription factors (TFs), and the mechanisms underlying the maintenance and differentiation of tro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf0805a99576993e6d119926d38ab873
https://doi.org/10.1093/nar/gkad215
https://doi.org/10.1093/nar/gkad215