Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Bullock William H"'
Autor:
Bullock, William H.1,2 (AUTHOR)
Publikováno v:
Critical Reviews in Toxicology. Sep2020, Vol. 50 Issue 8, p673-676. 4p.
Akademický článek
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Autor:
Bullock, William H.1 (AUTHOR)
Publikováno v:
Critical Reviews in Toxicology. Nov2020, Vol. 50 Issue 10, p955-956. 2p.
Autor:
Nicole Barucci, Herbert Ogutu, Laurel Sweet, Ronda Ott-Morgan, Louis-David Cantin, Yaxin Li, James N. Livingston, Philip Wickens, Lei Zhu, Sidney X. Liang, Jennifer Burke, Timothy B. Lowinger, Zhonghua Zhang, Bullock William H, Michelle Daly, Robert Schoenleber, Lynn Decarr, Steven Magnuson, Adrian Tersteegen, Ann Gore-Willse, Ellalahewage Kumarasinghe, Alan Olague, Jian Zhu, Marina Breuhaus, David E. Gunn, Margit L. MacDougall, Thomas H. Claus, Helana Hoover-Litty
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2869-2873
Modulation of cAMP levels has been linked to insulin secretion in preclinical animal models and in humans. The high expression of PDE-10A in pancreatic islets suggested that inhibition of this enzyme may provide the necessary modulation to elicit inc
Autor:
Jeffrey Shapiro, Bullock William H, Christine Keiper, Manami Tsutsumi, Ling Yang, Roger B Clark, Xin Ma, Sidney X. Liang, James N. Livingston, Louis-David Cantin, Christiana Iwuagwu, Frederick Ehrgott, Jeffrey Johnson, Thomas H. Claus, Ken Boakye, Herbert Ogutu, Christopher Town, Michael Burns, Michelle Daly, Robert Schoenleber, Fernando E. delaCruz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1056-1061
Modulation of PPAR activities represents an attractive approach for the treatment of diabetes with associated cardiovascular complications. The indanylacetic acid structural motif has proven useful in the generation of potent and tunable PPAR ligands
Autor:
Yamin Wang, Manami Tsutsumi, Gretchen Mannelly, Xin Ma, Laurel Sweet, David P. Dickson, Tatiana E. Shelekhin, Kake Zhao, Jian Zhu, Andreas Stolle, Mareli Rodriguez, Stephen J. O'connor, Philip Coish, Helana Hoover-Litty, Mary-Katherine Monahan, Qian Zhao, Chengzhi Zhang, Thomas H. Claus, Fernando Dela Cruz, Ingo Muegge, Mingbao Zhang, Dongping Fan, Derek B. Lowe, Miao Dai, Tindy Li, Lei Zhu, Neil Bifulco, Ming Wang, Hai-Jun Zhang, Bullock William H
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:297-301
A series of oxazole-substituted indanylacetic acids were prepared which show a spectrum of activity as ligands for PPAR nuclear receptor subtypes.
Publikováno v:
Synthetic Communications. 34:4023-4030
A general and practical synthetic method was developed for indoline‐5‐sulfonic acids bearing a thiazole heterocycle attached to the nitrogen atom. Two select sulfonic acids were further converted to their corresponding sulfonyl chlorides, key int
Akademický článek
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Autor:
Gaetan H. Ladouceur, Bullock William H, Cheng Bi, Mingbao Zhang, Jefferson Chin, Robert Dally, Raymond Reeves
Publikováno v:
Tetrahedron Letters. 45:5229-5231
Three novel, optically active, 6-substituted 2-(aminomethyl)chromans were synthesized from readily available chroman 2-carboxylic acid precursors. These chroman-containing primary amines are useful building blocks for the synthesis of chroman-derived
Autor:
Tatiana E. Shelekhin, William P. Esler, Philip Wickens, Lei Wang, Weifeng Tang, Chih-Yuan Chuang, James N. Livingston, Uday Khire, Libing Chen, Philip Coish, Thomas H. Claus, Stephen O'connor, Andrea Mcclure, Laurel Sweet, James A. Kristie, Robert Schoenleber, Stephen J. Gardell, Donald Bierer, Zahra Fathi, Xiao-Gao Liu, Michael Brands, Georgiy Bondar, Wenlang Fu, Brian T. Bloomquist, Alexandros Vakalopoulos, Derek B. Lowe, Joachim Rudolph, Philip D. Ramsden, Lin Yi, Bullock William H, Astrid A. Ortiz, Martin Michels
Publikováno v:
Journal of medicinal chemistry. 50(21)
The peptide hormone ghrelin is the endogenous ligand for the type 1a growth hormone secretagogue receptor (GHS-R1a) and the only currently known circulating appetite stimulant. GHS-R1a antagonism has therefore been proposed as a potential approach fo