Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Bull JA"'
Publikováno v:
Proceedings of the IEEE. 110:523-540
Over the past 25 years, there has been an unparalleled increase in understanding of cancer biology. This transformation is exemplified by Hanahan and Weinberg’s decision in 2011 to expand their original Hallmarks of Cancer from six traits to ten! A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4559328d73925328a2c7b2a3472ed7c0
https://doi.org/10.1109/jproc.2021.3136715
https://doi.org/10.1109/jproc.2021.3136715
3-Sulfanyl-oxetanes are presented as promising novel bioisosteric replacements for thioesters or benzyl sulfides. From oxetan-3-ols, a mild and inexpensive Li catalyst enables chemoselective C–OH activation and thiol alkylation. Oxetane sulfides ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::13e3fddab41f2e13709baa9ed474272f
http://hdl.handle.net/10044/1/54378
http://hdl.handle.net/10044/1/54378
Cyclopropanes provide important design elements in medicinal chemistry and are widely present in drug compounds. Here we describe a strategy and extensive synthetic studies for the preparation of a diverse collection of cyclopropane-containing fragme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::7e7445f384ddc32bd7eb2f014615b06a
http://hdl.handle.net/10044/1/50238
http://hdl.handle.net/10044/1/50238
Autor:
Kubánková, M, López-Duarte, I, Bull, JA, Vadukul, DM, Serpell, LC, de Saint Victor, M, Stride, E, Kuimova, MK
Changes in microscopic viscosity and macromolecular crowding accompany the transition of proteins from their monomeric forms into highly organised fibrillar states. Previously, we have demonstrated that viscosity sensitive fluorophores termed 'molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b63664756019bd7814c153ab88378610
http://hdl.handle.net/10044/1/49115
http://hdl.handle.net/10044/1/49115
The first examples of 3,3-diaryloxetanes are prepared in a lithium-catalyzed and substrate dependent divergent Friedel–Crafts reaction. para-Selective Friedel–Crafts reactions of phenols using oxetan-3-ols afford 3,3-diaryloxetanes by displacemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::2ad07361cf2a481eb079e05837593547
http://hdl.handle.net/10044/1/39877
http://hdl.handle.net/10044/1/39877
The 4-membered oxetane ring has been increasingly exploited for its behaviors, i.e. influence on physicochemical properties as a stable motif in medicinal chemistry, and propensity to undergo ring opening reactions as a synthetic intermediate. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::7883e6178dbc21d0b3b66ed48f9b693a
http://hdl.handle.net/10044/1/38941
http://hdl.handle.net/10044/1/38941
Oxetanes offer exciting potential as structural motifs and intermediates in drug discovery and materials science. Here an efficient strategy for the synthesis of oxetane rings incorporating pendant functional groups is described. A wide variety of ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::64c93195dab21eb6e70d2f3e2c0e126c
http://hdl.handle.net/10044/1/22053
http://hdl.handle.net/10044/1/22053
Functionalization of C(sp3)−H bonds at the unactivated 3-position of proline derivatives has been achieved using aryl iodides and palladium catalysis. This directly affords cis-2,3-disubstituted pyrrolidines as single stereoisomers. 3- Arylation oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::22ec07a4de402a0330407f6cb954121b
http://hdl.handle.net/10044/1/15595
http://hdl.handle.net/10044/1/15595