Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Bulian Deng"'
Autor:
Xiaopeng Peng, Ziwen Yu, Goverdhan Surineni, Bulian Deng, Meizhu Zhang, Chuan Li, Zhiqiang Sun, Wanyi Pan, Yao Liu, Shenglan Liu, Bin Yu, Jianjun Chen
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
In this study, a novel series of histone deacetylases 6 (HDAC6) inhibitors containing polycyclic aromatic rings were discovered and evaluated for their pharmacological activities. The most potent compound 10c exhibited high HDAC6 inhibitory activity
Externí odkaz:
https://doaj.org/article/88ad33862024465eabf4c987c34fa3eb
Autor:
Bulian Deng, Zhiqiang Sun, Yuxi Wang, Ruiyao Mai, Zichao Yang, Yichang Ren, Jin Liu, Junli Huang, Zeli Ma, Ting Chen, Canjun Zeng, Jianjun Chen
Publikováno v:
Bioorganicmedicinal chemistry. 76
Through structural optimization and ring fusion strategy, we designed a series of novel imidazo[1,2-a]pyrazine derivatives as potential tubulin inhibitors. These compounds displayed potent anti-proliferative activities (micromolar to nanomolar) again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27c897f637dd99b79e96d91963b7c14
https://pubmed.ncbi.nlm.nih.gov/36455508
https://pubmed.ncbi.nlm.nih.gov/36455508
Autor:
Jin Liu, Lin Yuan, Yong Ruan, Bulian Deng, Zicao Yang, Yichang Ren, Ling Li, Ting Liu, Huiting Zhao, Ruiyao Mai, Jianjun Chen
Publikováno v:
Journal of medicinal chemistry. 65(9)
The activation of the cyclic GMP-AMP synthase-stimulator of interferon gene (STING) pathway has been associated with the pathogenesis of many autoimmune and inflammatory disorders, and small molecules targeting STING have emerged as a new therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0222399f73bad0e986f9f898ea15f434
https://pubmed.ncbi.nlm.nih.gov/35452223
https://pubmed.ncbi.nlm.nih.gov/35452223
Autor:
Zhiqiang Sun, Bulian Deng, Zichao Yang, Ruiyao Mai, Junli Huang, Zeli Ma, Ting Chen, Jianjun Chen
Publikováno v:
European Journal of Medicinal Chemistry. 239:114544
Overexpression of histone deacetylase 8 (HDAC8) is associated with various diseases such as cancer. Thus, compounds that can modulate HDAC8 levels have therapeutic potential for these diseases. Based on the proteolysis targeting chimera (PROTAC) stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2c08a882588681f6083e6d5ef2758c
https://doi.org/10.1016/j.ejmech.2022.114544
https://doi.org/10.1016/j.ejmech.2022.114544