Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Bulent Ataman"'
Autor:
Maria H Chahrour, Timothy W Yu, Elaine T Lim, Bulent Ataman, Michael E Coulter, R Sean Hill, Christine R Stevens, Christian R Schubert, ARRA Autism Sequencing Collaboration, Michael E Greenberg, Stacey B Gabriel, Christopher A Walsh
Publikováno v:
PLoS Genetics, Vol 8, Iss 4, p e1002635 (2012)
Although autism has a clear genetic component, the high genetic heterogeneity of the disorder has been a challenge for the identification of causative genes. We used homozygosity analysis to identify probands from nonconsanguineous families that show
Externí odkaz:
https://doaj.org/article/2902585976fa4160a7a77dc60c4d5f5a
Publikováno v:
PLoS Biology, Vol 7, Iss 8, p e1000184 (2009)
Synapse remodeling is an extremely dynamic process, often regulated by neural activity. Here we show during activity-dependent synaptic growth at the Drosophila NMJ many immature synaptic boutons fail to form stable postsynaptic contacts, are selecti
Externí odkaz:
https://doaj.org/article/8372267e4f87472b91b885e4b546e631
Autor:
Eric C. Griffith, Jesse M. Engreitz, Gabriella L. Boulting, Michael R. Blanchard, Daniel Hochbaum, Ava C. Carter, David A. Harmin, Michael E. Greenberg, Maxwell A. Sherman, Adam J. Granger, Kevin Mei, Sinisa Hrvatin, Bulent Ataman, Marty G. Yang, Ershela Durresi
Publikováno v:
Nature neuroscience
Neuronal activity-dependent gene expression is essential for brain development. Although transcriptional and epigenetic effects of neuronal activity have been explored in mice, such an investigation is lacking in humans. Because alterations in GABAer
Autor:
Anh Thu N. Lam, Sarah Servattalab, Michael E. Greenberg, R. Sean Hill, Bhaven K. Mehta, Timothy W. Yu, Guzman Sanchez-Schmitz, Kyriacos Markianos, Klaus Schmitz-Abe, Ryan N. Doan, Maria H. Chahrour, Bulent Ataman, Christopher A. Walsh, Eric M. Morrow
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
More than 98% of the human genome is made up of non-coding DNA, but techniques to ascertain its contribution to human disease have lagged far behind our understanding of protein coding variations. Autism spectrum disorder (ASD) has been mostly associ
Autor:
Hsin-Yi Henry Ho, Brenda L. Bloodgood, Michael J. Soskis, Nikhil Sharma, Kevan M. Shokat, Christopher W. Cowan, Alex A. Rubin, Michael E. Greenberg, Janine Zieg, Athar N. Malik, Bulent Ataman, Michael A. Robichaux, Chao Zhang
Publikováno v:
Nature neuroscience
EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly. In addition, as EphBs signal through multiple mech
Autor:
Maria H. Chahrour, Mihovil Pletikos, Vladimir K. Berezovskii, Gabriella L. Boulting, Christine Stevens, Athar N. Malik, Bulent Ataman, Ee Lynn Yap, Margaret S. Livingstone, David A. Harmin, Marty G. Yang, Nenad Sestan, Christopher A. Walsh, Mollie Baker-Salisbury, Alex A. Rubin, Linda Hu, Ivo Spiegel, Michael E. Greenberg, Kevin Mei, Nikhil Sharma, Jennifer N. Partlow, Ershela Durresi, Mazhar Adli, Eric C. Griffith
Publikováno v:
Nature. 539(7628)
Sensory stimuli drive the maturation and function of the mammalian nervous system in part through the activation of gene expression networks that regulate synapse development and plasticity. These networks have primarily been studied in mice, and it
Autor:
Vivian Budnik, Preethi Ramachandran, Ceren Korkut, James A. Ashley, Romina Barria, Bulent Ataman, Norberto G. Gherbesi
Publikováno v:
Cell. 139:393-404
SummaryWnts play pivotal roles during development and in the mature nervous system. However, the mechanism by which Wnts traffic between cells has remained elusive. Here we demonstrate a mechanism of Wnt transmission through release of exosome-like v
Autor:
Vivian Budnik, Michael Gorczyca, James A. Ashley, Wernher Fouquet, Bulent Ataman, Stephan J. Sigrist, Preethi Ramachandran
Publikováno v:
Neuron. 57(5):705-718
Summary Activity-dependent modifications in synapse structure play a key role in synaptic development and plasticity, but the signaling mechanisms involved are poorly understood. We demonstrate that glutamatergic Drosophila neuromuscular junctions un
Autor:
Sven Loebrich, Emily Hager, Bulent Ataman, Elly Nedivi, Mette Rathje, Michael E. Greenberg, David A. Harmin
Publikováno v:
Molecular and cellular neurosciences. 71
Bipolar disorder (BD) is a prevalent and severe mood disorder characterized by recurrent episodes of mania and depression. Both genetic and environmental factors have been implicated in BD etiology, but the biological underpinnings remain elusive. Re
Autor:
James A. Ashley, David Gorczyca, Michael Gorczyca, Carolin Wichmann, Vivian Budnik, Bulent Ataman, Dennis Mathew, Stephan J. Sigrist
Publikováno v:
Proceedings of the National Academy of Sciences. 103:7841-7846
The Wingless pathway plays an essential role during synapse development. Recent studies at Drosophila glutamatergic synapses suggest that Wingless is secreted by motor neuron terminals and binds to postsynaptic Drosophila Frizzled-2 (DFz2) receptors.