Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Bulat Faezov"'
Autor:
Jason S. Wasserman, Bulat Faezov, Kishan R. Patel, Alison M. Kurimchak, Seren M. Palacio, David J. Glass, Holly Fowle, Brennan C. McEwan, Qifang Xu, Ziran Zhao, Lauren Cressey, Neil Johnson, James S. Duncan, Arminja N. Kettenbach, Roland L. Dunbrack, Xavier Graña
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The Ser/Thr protein phosphatase 2 A (PP2A) regulates the dephosphorylation of many phosphoproteins. Substrate recognition are mediated by B regulatory subunits. Here, we report the identification of a substrate conserved motif [RK]-V-x-x-[VI
Externí odkaz:
https://doaj.org/article/6e9017a5c5d34b82817862a82164f6a6
Autor:
Petr Makhov, Igor Bychkov, Bulat Faezov, Alexander Deneka, Alexander Kudinov, Emmanuelle Nicolas, Rohan Brebion, Eleanor Avril, Kathy Q. Cai, Leonid V. Kharin, Mark Voloshin, Elena Frantsiyants, Nikolay Karnaukhov, Oleg I. Kit, Iuliia Topchu, Rushaniya Fazliyeva, Anna S. Nikonova, Ilya G. Serebriiskii, Hossein Borghaei, Martin Edelman, Essel Dulaimi, Erica A. Golemis, Yanis Boumber
Publikováno v:
Oncogenesis, Vol 10, Iss 3, Pp 1-14 (2021)
Abstract Non-small cell lung cancer (NSCLC) has limited treatment options. Expression of the RNA-binding protein (RBP) Musashi-2 (MSI2) is elevated in a subset of non-small cell lung cancer (NSCLC) tumors upon progression, and drives NSCLC metastasis
Externí odkaz:
https://doaj.org/article/2ede848ef5274440b27190aa152d7cbe
Autor:
Bulat Faezov, Roland L Dunbrack
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0253411 (2021)
The Protein Data Bank (PDB) was established at Brookhaven National Laboratories in 1971 as an archive for biological macromolecular crystal structures. In mid 2021, the database has almost 180,000 structures solved by X-ray crystallography, nuclear m
Externí odkaz:
https://doaj.org/article/7f3f0cfc76ae4757a2a52e26dc666046
Autor:
Shreya M. Shah, Elena V. Demidova, Salena Ringenbach, Bulat Faezov, Mark Andrake, Pilar Mur, Julen Viana-Errasti, Joanne Xiu, Jeffrey Swensen, Laura Valle, Roland L. Dunbrack, Michael J. Hall, Sanjeevani Arora
SomaticPOLEmutations in the exonuclease domain (ExoD) are prevalent in colorectal cancer (CRC), endometrial cancer (EC), and others and typically lead to dramatically increased tumor mutation burden (TMB). To understand whether non-ExoD mutations als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7d894b98f1b2f61b7146890259c06e2
https://doi.org/10.1101/2022.12.15.520593
https://doi.org/10.1101/2022.12.15.520593
Autor:
Hoi-Yee Chow, Sofiia Karchugina, Brian J. Groendyke, Sean Toenjes, John Hatcher, Katherine A. Donovan, Eric S. Fischer, Gleb Abalakov, Bulat Faezov, Roland Dunbrack, Nathanael S. Gray, Jonathan Chernoff
Publikováno v:
J Med Chem
Amplification and/or overexpression of the PAK1 gene is common in several malignancies, and inhibition of PAK1 by small molecules has been shown to impede the growth and survival of such cells. Potent inhibitors of PAK1 and its close relatives, PAK2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df599ac0b6e838f9887b9345cac503a8
https://pubmed.ncbi.nlm.nih.gov/36416208
https://pubmed.ncbi.nlm.nih.gov/36416208
Autor:
Simon Kelow, Bulat Faezov, Qifang Xu, Mitchell Parker, Jared Adolf-Bryfogle, Roland L. Dunbrack
Antibody complementarity determining regions (CDRs) are loops within antibodies responsible for engaging antigens during the immune response and in antibody therapeutics and laboratory reagents. Since the 1980s, the conformations of the hypervariable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e24965aa3f96efe26f02adbfec0afc5
https://doi.org/10.1101/2022.10.12.511988
https://doi.org/10.1101/2022.10.12.511988
Autor:
Martin J. Edelman, Oleg I. Kit, Elena M. Frantsiyants, Rohan Brebion, Eleanor Avril, Kathy Q. Cai, Bulat Faezov, Iuliia Topchu, Rushaniya Fazliyeva, Ilya G. Serebriiskii, Emmanuelle Nicolas, Leonid V. Kharin, Petr Makhov, Yanis Boumber, Erica A. Golemis, Alexander E. Kudinov, Hossein Borghaei, Igor Bychkov, Alexander Y. Deneka, Anna S. Nikonova, Nikolay S. Karnaukhov, Essel Dulaimi, Mark Voloshin
Publikováno v:
Oncogenesis, Vol 10, Iss 3, Pp 1-14 (2021)
Oncogenesis
Oncogenesis
Non-small cell lung cancer (NSCLC) has limited treatment options. Expression of the RNA-binding protein (RBP) Musashi-2 (MSI2) is elevated in a subset of non-small cell lung cancer (NSCLC) tumors upon progression, and drives NSCLC metastasis. We eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3f337bb99129d6a76a8fd9939b769a
https://doaj.org/article/2ede848ef5274440b27190aa152d7cbe
https://doaj.org/article/2ede848ef5274440b27190aa152d7cbe
Autor:
Salena Ringenbach, Shreya M. Shah, Elena Demidova, Bulat Faezov, Mark D. Andrake, Pilar Mur, Joanne Xiu, Wolfgang Michael Korn, Sanjay Goel, Heinz-Josef Lenz, John Marshall, Anthony Frank Shields, Matthew James Oberley, David Spetzler, Laura Valle, Roland Dunbrack, Michael J. Hall, Sanjeevani Arora
Publikováno v:
Journal of Clinical Oncology. 41:224-224
224 Background: Driver mutations in the exonuclease domain (ExoD) of DNA polymerase epsilon ( POLE) have been associated with high tumor mutation burden (TMB). High TMB is an important marker for immunotherapy, and thus understanding the mechanisms t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02ab758fefda497379a8fbc1a70fda2c
https://doi.org/10.1200/jco.2023.41.4_suppl.224
https://doi.org/10.1200/jco.2023.41.4_suppl.224
Autor:
Roland L. Dunbrack, Bulat Faezov
The Protein Data Bank (PDB) was established at Brookhaven National Laboratories in 1971 as an archive for biological macromolecular crystal structures. In early 2021, the database has more than 175,000 structures solved by X-ray crystallography, nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1a6583f475420002e378cb0eb167b80
https://doi.org/10.1101/2021.02.14.431128
https://doi.org/10.1101/2021.02.14.431128